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Items: 1 to 20 of 30


Ablation of the Ferroptosis Inhibitor Glutathione Peroxidase 4 in Neurons Results in Rapid Motor Neuron Degeneration and Paralysis.

Chen L, Hambright WS, Na R, Ran Q.

J Biol Chem. 2015 Nov 20;290(47):28097-106. doi: 10.1074/jbc.M115.680090. Epub 2015 Sep 23.


Ferroptosis in p53-dependent oncosuppression and organismal homeostasis.

Galluzzi L, Bravo-San Pedro JM, Kroemer G.

Cell Death Differ. 2015 Aug;22(8):1237-8. doi: 10.1038/cdd.2015.54. No abstract available.


Identification of artesunate as a specific activator of ferroptosis in pancreatic cancer cells.

Eling N, Reuter L, Hazin J, Hamacher-Brady A, Brady NR.

Oncoscience. 2015 May 2;2(5):517-32. eCollection 2015.


HSPB1 as a novel regulator of ferroptotic cancer cell death.

Sun X, Ou Z, Xie M, Kang R, Fan Y, Niu X, Wang H, Cao L, Tang D.

Oncogene. 2015 Nov 5;34(45):5617-25. doi: 10.1038/onc.2015.32. Epub 2015 Mar 2.


Linking tumor mutations to drug responses via a quantitative chemical-genetic interaction map.

Martins MM, Zhou AY, Corella A, Horiuchi D, Yau C, Rakshandehroo T, Gordan JD, Levin RS, Johnson J, Jascur J, Shales M, Sorrentino A, Cheah J, Clemons PA, Shamji AF, Schreiber SL, Krogan NJ, Shokat KM, McCormick F, Goga A, Bandyopadhyay S.

Cancer Discov. 2015 Feb;5(2):154-67. doi: 10.1158/2159-8290.CD-14-0552. Epub 2014 Dec 12.


Biometals and their therapeutic implications in Alzheimer's disease.

Ayton S, Lei P, Bush AI.

Neurotherapeutics. 2015 Jan;12(1):109-20. doi: 10.1007/s13311-014-0312-z.


Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease models.

Skouta R, Dixon SJ, Wang J, Dunn DE, Orman M, Shimada K, Rosenberg PA, Lo DC, Weinberg JM, Linkermann A, Stockwell BR.

J Am Chem Soc. 2014 Mar 26;136(12):4551-6. doi: 10.1021/ja411006a. Epub 2014 Mar 14.


Regulation of ferroptotic cancer cell death by GPX4.

Yang WS, SriRamaratnam R, Welsch ME, Shimada K, Skouta R, Viswanathan VS, Cheah JH, Clemons PA, Shamji AF, Clish CB, Brown LM, Girotti AW, Cornish VW, Schreiber SL, Stockwell BR.

Cell. 2014 Jan 16;156(1-2):317-31. doi: 10.1016/j.cell.2013.12.010.


A delicate balance: Iron metabolism and diseases of the brain.

Hare D, Ayton S, Bush A, Lei P.

Front Aging Neurosci. 2013 Jul 18;5:34. doi: 10.3389/fnagi.2013.00034. eCollection 2013.


VDAC3 and Mps1 negatively regulate ciliogenesis.

Majumder S, Fisk HA.

Cell Cycle. 2013 Mar 1;12(5):849-58. doi: 10.4161/cc.23824. Epub 2013 Feb 6.


A Potent and Selective Quinoxalinone-Based STK33 Inhibitor Does Not Show Synthetic Lethality in KRAS-Dependent Cells.

Weïwer M, Spoonamore J, Wei J, Guichard B, Ross NT, Masson K, Silkworth W, Dandapani S, Palmer M, Scherer CA, Stern AM, Schreiber SL, Munoz B.

ACS Med Chem Lett. 2012 Dec 13;3(12):1034-1038. Epub 2012 Oct 22.


VDAC1: from structure to cancer therapy.

Shoshan-Barmatz V, Mizrachi D.

Front Oncol. 2012 Nov 29;2:164. doi: 10.3389/fonc.2012.00164. eCollection 2012.


VDAC3 regulates centriole assembly by targeting Mps1 to centrosomes.

Majumder S, Slabodnick M, Pike A, Marquardt J, Fisk HA.

Cell Cycle. 2012 Oct 1;11(19):3666-78. doi: 10.4161/cc.21927. Epub 2012 Aug 30.


Design and synthesis of Pictet-Spengler condensation products that exhibit oncogenic-RAS synthetic lethality and induce non-apoptotic cell death.

Skouta R, Hayano M, Shimada K, Stockwell BR.

Bioorg Med Chem Lett. 2012 Sep 1;22(17):5707-13. doi: 10.1016/j.bmcl.2012.06.077. Epub 2012 Jun 30.


The neglected significance of "antioxidative stress".

Poljsak B, Milisav I.

Oxid Med Cell Longev. 2012;2012:480895. doi: 10.1155/2012/480895. Epub 2012 May 8. Review.


Ferroptosis: an iron-dependent form of nonapoptotic cell death.

Dixon SJ, Lemberg KM, Lamprecht MR, Skouta R, Zaitsev EM, Gleason CE, Patel DN, Bauer AJ, Cantley AM, Yang WS, Morrison B 3rd, Stockwell BR.

Cell. 2012 May 25;149(5):1060-72. doi: 10.1016/j.cell.2012.03.042.


Development of small-molecule probes that selectively kill cells induced to express mutant RAS.

Weïwer M, Bittker JA, Lewis TA, Shimada K, Yang WS, MacPherson L, Dandapani S, Palmer M, Stockwell BR, Schreiber SL, Munoz B.

Bioorg Med Chem Lett. 2012 Feb 15;22(4):1822-6. doi: 10.1016/j.bmcl.2011.09.047. Epub 2011 Sep 28.


Identification of Simple Compounds with Microtubule-Binding Activity That Inhibit Cancer Cell Growth with High Potency.

Yang WS, Shimada K, Delva D, Patel M, Ode E, Skouta R, Stockwell BR.

ACS Med Chem Lett. 2012 Jan 12;3(1):35-38. Epub 2011 Oct 31.


Studying synthetic lethal interactions in the zebrafish system: insight into disease genes and mechanisms.

Hajeri VA, Amatruda JF.

Dis Model Mech. 2012 Jan;5(1):33-7. doi: 10.1242/dmm.007989. Epub 2011 Nov 22. Review.


Modulatory profiling identifies mechanisms of small molecule-induced cell death.

Wolpaw AJ, Shimada K, Skouta R, Welsch ME, Akavia UD, Pe'er D, Shaik F, Bulinski JC, Stockwell BR.

Proc Natl Acad Sci U S A. 2011 Sep 27;108(39):E771-80. doi: 10.1073/pnas.1106149108. Epub 2011 Sep 6.

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