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Results: 12

1.

A Target Repurposing Approach Identifies N-myristoyltransferase as a New Candidate Drug Target in Filarial Nematodes.

Galvin BD, Li Z, Villemaine E, Poole CB, Chapman MS, Pollastri MP, Wyatt PG, Carlow CK.

PLoS Negl Trop Dis. 2014 Sep 4;8(9):e3145. doi: 10.1371/journal.pntd.0003145. eCollection 2014 Sep.

PMID:
25188325
[PubMed - in process]
Free PMC Article
2.

Diverse modes of binding in structures of Leishmania major N-myristoyltransferase with selective inhibitors.

Brannigan JA, Roberts SM, Bell AS, Hutton JA, Hodgkinson MR, Tate EW, Leatherbarrow RJ, Smith DF, Wilkinson AJ.

IUCrJ. 2014 Jun 17;1(Pt 4):250-60. doi: 10.1107/S2052252514013001. eCollection 2014 Jul 1.

PMID:
25075346
[PubMed]
Free PMC Article
3.

Discovery of novel and ligand-efficient inhibitors of Plasmodium falciparum and Plasmodium vivax N-myristoyltransferase.

Rackham MD, Brannigan JA, Moss DK, Yu Z, Wilkinson AJ, Holder AA, Tate EW, Leatherbarrow RJ.

J Med Chem. 2013 Jan 10;56(1):371-5. doi: 10.1021/jm301474t. Epub 2012 Dec 17.

PMID:
23170970
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Design and synthesis of inhibitors of Plasmodium falciparum N-myristoyltransferase, a promising target for antimalarial drug discovery.

Yu Z, Brannigan JA, Moss DK, Brzozowski AM, Wilkinson AJ, Holder AA, Tate EW, Leatherbarrow RJ.

J Med Chem. 2012 Oct 25;55(20):8879-90. doi: 10.1021/jm301160h. Epub 2012 Oct 15.

PMID:
23035716
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

A new, robust, and nonradioactive approach for exploring N-myristoylation.

Rampoldi F, Sandhoff R, Owen RW, Gröne HJ, Porubsky S.

J Lipid Res. 2012 Nov;53(11):2459-68. doi: 10.1194/jlr.D026997. Epub 2012 Jul 24.

PMID:
22829651
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Selective inhibitors of protozoan protein N-myristoyltransferases as starting points for tropical disease medicinal chemistry programs.

Bell AS, Mills JE, Williams GP, Brannigan JA, Wilkinson AJ, Parkinson T, Leatherbarrow RJ, Tate EW, Holder AA, Smith DF.

PLoS Negl Trop Dis. 2012;6(4):e1625. doi: 10.1371/journal.pntd.0001625. Epub 2012 Apr 24.

PMID:
22545171
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Discovery of Plasmodium vivax N-myristoyltransferase inhibitors: screening, synthesis, and structural characterization of their binding mode.

Goncalves V, Brannigan JA, Whalley D, Ansell KH, Saxty B, Holder AA, Wilkinson AJ, Tate EW, Leatherbarrow RJ.

J Med Chem. 2012 Apr 12;55(7):3578-82. doi: 10.1021/jm300040p. Epub 2012 Apr 3.

PMID:
22439843
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Discovery of a novel class of orally active trypanocidal N-myristoyltransferase inhibitors.

Brand S, Cleghorn LA, McElroy SP, Robinson DA, Smith VC, Hallyburton I, Harrison JR, Norcross NR, Spinks D, Bayliss T, Norval S, Stojanovski L, Torrie LS, Frearson JA, Brenk R, Fairlamb AH, Ferguson MA, Read KD, Wyatt PG, Gilbert IH.

J Med Chem. 2012 Jan 12;55(1):140-52. doi: 10.1021/jm201091t. Epub 2011 Dec 7.

PMID:
22148754
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

A fluorescence-based assay for N-myristoyltransferase activity.

Goncalves V, Brannigan JA, Thinon E, Olaleye TO, Serwa R, Lanzarone S, Wilkinson AJ, Tate EW, Leatherbarrow RJ.

Anal Biochem. 2012 Feb 1;421(1):342-4. doi: 10.1016/j.ab.2011.10.013. Epub 2011 Oct 14.

PMID:
22051857
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

State of the art in African trypanosome drug discovery.

Jacobs RT, Nare B, Phillips MA.

Curr Top Med Chem. 2011;11(10):1255-74. Review.

PMID:
21401507
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

N-myristoyltransferase inhibitors as new leads to treat sleeping sickness.

Frearson JA, Brand S, McElroy SP, Cleghorn LA, Smid O, Stojanovski L, Price HP, Guther ML, Torrie LS, Robinson DA, Hallyburton I, Mpamhanga CP, Brannigan JA, Wilkinson AJ, Hodgkinson M, Hui R, Qiu W, Raimi OG, van Aalten DM, Brenk R, Gilbert IH, Read KD, Fairlamb AH, Ferguson MA, Smith DF, Wyatt PG.

Nature. 2010 Apr 1;464(7289):728-32. doi: 10.1038/nature08893.

PMID:
20360736
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Protein myristoylation in health and disease.

Wright MH, Heal WP, Mann DJ, Tate EW.

J Chem Biol. 2010 Mar;3(1):19-35. doi: 10.1007/s12154-009-0032-8. Epub 2009 Nov 7.

PMID:
19898886
[PubMed]
Free PMC Article

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