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HIV-tuberculosis-associated immune reconstitution inflammatory syndrome is characterized by Toll-like receptor and inflammasome signalling.

Lai RP, Meintjes G, Wilkinson KA, Graham CM, Marais S, Van der Plas H, Deffur A, Schutz C, Bloom C, Munagala I, Anguiano E, Goliath R, Maartens G, Banchereau J, Chaussabel D, O'Garra A, Wilkinson RJ.

Nat Commun. 2015 Sep 24;6:8451. doi: 10.1038/ncomms9451.


Lower Pre-Treatment T Cell Activation in Early- and Late-Onset Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome.

Goovaerts O, Jennes W, Massinga-Loembé M, Ondoa P, Ceulemans A, Vereecken C, Worodria W, Mayanja-Kizza H, Colebunders R, Kestens L; TB-IRIS Study Group.

PLoS One. 2015 Jul 24;10(7):e0133924. doi: 10.1371/journal.pone.0133924. eCollection 2015.


Immunological profiling of tuberculosis-associated immune reconstitution inflammatory syndrome and non-immune reconstitution inflammatory syndrome death in HIV-infected adults with pulmonary tuberculosis starting antiretroviral therapy: a prospective observational cohort study.

Ravimohan S, Tamuhla N, Steenhoff AP, Letlhogile R, Nfanyana K, Bellamy SL, MacGregor RR, Gross R, Weissman D, Bisson GP.

Lancet Infect Dis. 2015 Apr;15(4):429-38. doi: 10.1016/S1473-3099(15)70008-3. Epub 2015 Feb 9. Erratum in: Lancet Infect Dis. 2015 May;15(5):505.


Predictors and outcomes of Mycobacterium tuberculosis bacteremia among patients with HIV and tuberculosis co-infection enrolled in the ACTG A5221 STRIDE study.

Crump JA, Wu X, Kendall MA, Ive PD, Kumwenda JJ, Grinsztejn B, Jentsch U, Swindells S.

BMC Infect Dis. 2015 Jan 13;15:12. doi: 10.1186/s12879-014-0735-5.


Neutrophil-associated central nervous system inflammation in tuberculous meningitis immune reconstitution inflammatory syndrome.

Marais S, Wilkinson KA, Lesosky M, Coussens AK, Deffur A, Pepper DJ, Schutz C, Ismail Z, Meintjes G, Wilkinson RJ.

Clin Infect Dis. 2014 Dec 1;59(11):1638-47. doi: 10.1093/cid/ciu641. Epub 2014 Aug 8.


The impact of HAART initiation timing on HIV-TB co-infected patients, a retrospective cohort study.

Yang CH, Chen KJ, Tsai JJ, Lin YH, Cheng SH, Wang KF, Chiou HY.

BMC Infect Dis. 2014 Jun 4;14:304. doi: 10.1186/1471-2334-14-304.


Incidence of paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome and impact on patient outcome.

Bonnet M, Baudin E, Jani IV, Nunes E, Verhoustraten F, Calmy A, Bastos R, Bhatt NB, Michon C.

PLoS One. 2013 Dec 18;8(12):e84585. doi: 10.1371/journal.pone.0084585. eCollection 2013. Erratum in: PLoS One. 2014;9(1). doi:10.1371/annotation/15d01128-2495-4b95-8fe8-8702190fdb0e.


LPS-binding protein and IL-6 mark paradoxical tuberculosis immune reconstitution inflammatory syndrome in HIV patients.

Goovaerts O, Jennes W, Massinga-Loembé M, Ceulemans A, Worodria W, Mayanja-Kizza H, Colebunders R, Kestens L; TB-IRIS Study Group.

PLoS One. 2013 Nov 28;8(11):e81856. doi: 10.1371/journal.pone.0081856. eCollection 2013.


Management of HIV-associated tuberculosis in resource-limited settings: a state-of-the-art review.

Lawn SD, Meintjes G, McIlleron H, Harries AD, Wood R.

BMC Med. 2013 Dec 2;11:253. doi: 10.1186/1741-7015-11-253. Review.


Changes to antiretroviral drug regimens during integrated TB-HIV treatment: results of the SAPiT trial.

Naidoo A, Naidoo K, Yende-Zuma N, Gengiah TN, Padayatchi N, Gray AL, Bamber S, Nair G, Karim SS.

Antivir Ther. 2014;19(2):161-9. doi: 10.3851/IMP2701. Epub 2013 Oct 31.


HIV-1 and the immune response to TB.

Walker NF, Meintjes G, Wilkinson RJ.

Future Virol. 2013 Jan;8(1):57-80.


Incidence, clinical spectrum, risk factors and impact of HIV-associated immune reconstitution inflammatory syndrome in South Africa.

Haddow LJ, Moosa MY, Mosam A, Moodley P, Parboosing R, Easterbrook PJ.

PLoS One. 2012;7(11):e40623. doi: 10.1371/journal.pone.0040623. Epub 2012 Nov 12.


Frequency, severity, and prediction of tuberculous meningitis immune reconstitution inflammatory syndrome.

Marais S, Meintjes G, Pepper DJ, Dodd LE, Schutz C, Ismail Z, Wilkinson KA, Wilkinson RJ.

Clin Infect Dis. 2013 Feb;56(3):450-60. doi: 10.1093/cid/cis899. Epub 2012 Oct 24.


The immune reconstitution inflammatory syndrome after antiretroviral therapy initiation in patients with tuberculosis: findings from the SAPiT trial.

Naidoo K, Yende-Zuma N, Padayatchi N, Naidoo K, Jithoo N, Nair G, Bamber S, Gengiah S, El-Sadr WM, Friedland G, Abdool Karim S.

Ann Intern Med. 2012 Sep 4;157(5):313-24. doi: 10.7326/0003-4819-157-5-201209040-00004.


Timing of antiretroviral therapy for HIV-1 infection and tuberculosis.

Havlir DV, Kendall MA, Ive P, Kumwenda J, Swindells S, Qasba SS, Luetkemeyer AF, Hogg E, Rooney JF, Wu X, Hosseinipour MC, Lalloo U, Veloso VG, Some FF, Kumarasamy N, Padayatchi N, Santos BR, Reid S, Hakim J, Mohapi L, Mugyenyi P, Sanchez J, Lama JR, Pape JW, Sanchez A, Asmelash A, Moko E, Sawe F, Andersen J, Sanne I; AIDS Clinical Trials Group Study A5221.

N Engl J Med. 2011 Oct 20;365(16):1482-91. doi: 10.1056/NEJMoa1013607.


Effectiveness of early antiretroviral therapy initiation to improve survival among HIV-infected adults with tuberculosis: a retrospective cohort study.

Franke MF, Robins JM, Mugabo J, Kaigamba F, Cain LE, Fleming JG, Murray MB.

PLoS Med. 2011 May;8(5):e1001029. doi: 10.1371/journal.pmed.1001029. Epub 2011 May 3.


Pathogenesis and prevention of immune reconstitution disease during antiretroviral therapy.

Lawn SD, Meintjes G.

Expert Rev Anti Infect Ther. 2011 Apr;9(4):415-30. doi: 10.1586/eri.11.21. Review.


Timing of antiretroviral therapy for HIV in the setting of TB treatment.

Piggott DA, Karakousis PC.

Clin Dev Immunol. 2011;2011:103917. doi: 10.1155/2011/103917. Epub 2010 Dec 27. Review.


Initiating antiretrovirals during tuberculosis treatment: a drug safety review.

Gengiah TN, Gray AL, Naidoo K, Karim QA.

Expert Opin Drug Saf. 2011 Jul;10(4):559-74. doi: 10.1517/14740338.2011.546783. Epub 2011 Jan 5. Review.

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