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Cited In for PubMed (Select 18164066)


Complement activation and choriocapillaris loss in early AMD: implications for pathophysiology and therapy.

Whitmore SS, Sohn EH, Chirco KR, Drack AV, Stone EM, Tucker BA, Mullins RF.

Prog Retin Eye Res. 2015 Mar;45:1-29. doi: 10.1016/j.preteyeres.2014.11.005. Epub 2014 Dec 5. Review.


The autolysis of human HtrA1 is governed by the redox state of its N-terminal domain.

Risør MW, Poulsen ET, Thomsen LR, Dyrlund TF, Nielsen TA, Nielsen NC, Sanggaard KW, Enghild JJ.

Biochemistry. 2014 Jun 17;53(23):3851-7. doi: 10.1021/bi401633w. Epub 2014 Jun 6.


Spontaneous CNV in a novel mutant mouse is associated with early VEGF-A-driven angiogenesis and late-stage focal edema, neural cell loss, and dysfunction.

Nagai N, Lundh von Leithner P, Izumi-Nagai K, Hosking B, Chang B, Hurd R, Adamson P, Adamis AP, Foxton RH, Ng YS, Shima DT.

Invest Ophthalmol Vis Sci. 2014 May 20;55(6):3709-19. doi: 10.1167/iovs.14-13989.


FLT1 genetic variation predisposes to neovascular AMD in ethnically diverse populations and alters systemic FLT1 expression.

Owen LA, Morrison MA, Ahn J, Woo SJ, Sato H, Robinson R, Morgan DJ, Zacharaki F, Simeonova M, Uehara H, Chakravarthy U, Hogg RE, Ambati BK, Kotoula M, Baehr W, Haider NB, Silvestri G, Miller JW, Tsironi EE, Farrer LA, Kim IK, Park KH, DeAngelis MM.

Invest Ophthalmol Vis Sci. 2014 May 8;55(6):3543-54. doi: 10.1167/iovs.14-14047.


Cumulative association between age-related macular degeneration and less studied genetic variants in PLEKHA1/ARMS2/HTRA1: a meta and gene-cluster analysis.

Yu W, Dong S, Zhao C, Wang H, Dai F, Yang J.

Mol Biol Rep. 2013 Oct;40(10):5551-61. doi: 10.1007/s11033-013-2656-6. Epub 2013 Sep 7.


Variants at chromosome 10q26 locus and the expression of HTRA1 in the retina.

Wang G, Dubovy SR, Kovach JL, Schwartz SG, Agarwal A, Scott WK, Haines JL, Pericak-Vance MA.

Exp Eye Res. 2013 Jul;112:102-5. doi: 10.1016/j.exer.2013.04.019. Epub 2013 May 3.


Age-related macular degeneration-associated silent polymorphisms in HtrA1 impair its ability to antagonize insulin-like growth factor 1.

Jacobo SM, Deangelis MM, Kim IK, Kazlauskas A.

Mol Cell Biol. 2013 May;33(10):1976-90. doi: 10.1128/MCB.01283-12. Epub 2013 Mar 11.


Overexpression of HTRA1 leads to down-regulation of fibronectin and functional changes in RF/6A cells and HUVECs.

Jiang J, Huang L, Yu W, Wu X, Zhou P, Li X.

PLoS One. 2012;7(10):e46115. doi: 10.1371/journal.pone.0046115. Epub 2012 Oct 8.


Systems biology-based analysis implicates a novel role for vitamin D metabolism in the pathogenesis of age-related macular degeneration.

Morrison MA, Silveira AC, Huynh N, Jun G, Smith SE, Zacharaki F, Sato H, Loomis S, Andreoli MT, Adams SM, Radeke MJ, Jelcick AS, Yuan Y, Tsiloulis AN, Chatzoulis DZ, Silvestri G, Kotoula MG, Tsironi EE, Hollis BW, Chen R, Haider NB, Miller JW, Farrer LA, Hageman GS, Kim IK, Schaumberg DA, DeAngelis MM.

Hum Genomics. 2011 Oct;5(6):538-68.


Overexpression of HTRA1 leads to ultrastructural changes in the elastic layer of Bruch's membrane via cleavage of extracellular matrix components.

Vierkotten S, Muether PS, Fauser S.

PLoS One. 2011;6(8):e22959. doi: 10.1371/journal.pone.0022959. Epub 2011 Aug 2.


Clinical validation of a genetic model to estimate the risk of developing choroidal neovascular age-related macular degeneration.

Hageman GS, Gehrs K, Lejnine S, Bansal AT, Deangelis MM, Guymer RH, Baird PN, Allikmets R, Deciu C, Oeth P, Perlee LT.

Hum Genomics. 2011 Jul;5(5):420-40.


Identifying subtypes of patients with neovascular age-related macular degeneration by genotypic and cardiovascular risk characteristics.

Feehan M, Hartman J, Durante R, Morrison MA, Miller JW, Kim IK, DeAngelis MM.

BMC Med Genet. 2011 Jun 17;12:83. doi: 10.1186/1471-2350-12-83.


Genetics of age-related macular degeneration: current concepts, future directions.

Deangelis MM, Silveira AC, Carr EA, Kim IK.

Semin Ophthalmol. 2011 May;26(3):77-93. doi: 10.3109/08820538.2011.577129. Review.


Copy number variations in candidate genes in neovascular age-related macular degeneration.

Liu MM, Agrón E, Chew E, Meyerle C, Ferris FL 3rd, Chan CC, Tuo J.

Invest Ophthalmol Vis Sci. 2011 May 16;52(6):3129-35. doi: 10.1167/iovs.10-6735.


Inflammatory mediators and angiogenic factors in choroidal neovascularization: pathogenetic interactions and therapeutic implications.

Campa C, Costagliola C, Incorvaia C, Sheridan C, Semeraro F, De Nadai K, Sebastiani A, Parmeggiani F.

Mediators Inflamm. 2010;2010. pii: 546826. doi: 10.1155/2010/546826. Epub 2010 Aug 25. Review.


Genetic and functional dissection of HTRA1 and LOC387715 in age-related macular degeneration.

Yang Z, Tong Z, Chen Y, Zeng J, Lu F, Sun X, Zhao C, Wang K, Davey L, Chen H, London N, Muramatsu D, Salasar F, Carmona R, Kasuga D, Wang X, Bedell M, Dixie M, Zhao P, Yang R, Gibbs D, Liu X, Li Y, Li C, Li Y, Campochiaro B, Constantine R, Zack DJ, Campochiaro P, Fu Y, Li DY, Katsanis N, Zhang K.

PLoS Genet. 2010 Feb 5;6(2):e1000836. doi: 10.1371/journal.pgen.1000836.


Application of gene network analysis techniques identifies AXIN1/PDIA2 and endoglin haplotypes associated with bicuspid aortic valve.

Wooten EC, Iyer LK, Montefusco MC, Hedgepeth AK, Payne DD, Kapur NK, Housman DE, Mendelsohn ME, Huggins GS.

PLoS One. 2010 Jan 21;5(1):e8830. doi: 10.1371/journal.pone.0008830.


Comprehensive analysis of complement factor H and LOC387715/ARMS2/HTRA1 variants with respect to phenotype in advanced age-related macular degeneration.

Andreoli MT, Morrison MA, Kim BJ, Chen L, Adams SM, Miller JW, DeAngelis MM, Kim IK.

Am J Ophthalmol. 2009 Dec;148(6):869-74. doi: 10.1016/j.ajo.2009.07.002. Epub 2009 Oct 1.

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