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Cited In for PubMed (Select 18155743)


Immunogens Modeling a Fusion-Intermediate Conformation of gp41 Elicit Antibodies to the Membrane Proximal External Region of the HIV Envelope Glycoprotein.

Vassell R, He Y, Vennakalanti P, Dey AK, Zhuang M, Wang W, Sun Y, Biron-Sorek Z, Srivastava IK, LaBranche CC, Montefiori DC, Barnett SW, Weiss CD.

PLoS One. 2015 Jun 18;10(6):e0128562. doi: 10.1371/journal.pone.0128562. eCollection 2015.


Multimeric scaffolds displaying the HIV-1 envelope MPER induce MPER-specific antibodies and cross-neutralizing antibodies when co-immunized with gp160 DNA.

Krebs SJ, McBurney SP, Kovarik DN, Waddell CD, Jaworski JP, Sutton WF, Gomes MM, Trovato M, Waagmeester G, Barnett SJ, DeBerardinis P, Haigwood NL.

PLoS One. 2014 Dec 16;9(12):e113463. doi: 10.1371/journal.pone.0113463. eCollection 2014. Erratum in: PLoS One. 2015;10(3):e0120027.


HIV-1 Env-specific memory and germinal center B cells in C57BL/6 mice.

Soldemo M, Pedersen GK, Karlsson Hedestam GB.

Viruses. 2014 Sep 5;6(9):3400-14. doi: 10.3390/v6093400.


The stem of vesicular stomatitis virus G can be replaced with the HIV-1 Env membrane-proximal external region without loss of G function or membrane-proximal external region antigenic properties.

Lorenz IC, Nguyen HT, Kemelman M, Lindsay RW, Yuan M, Wright KJ, Arendt H, Back JW, DeStefano J, Hoffenberg S, Morrow G, Jurgens CK, Phogat SK, Zamb TJ, Parks CL.

AIDS Res Hum Retroviruses. 2014 Nov;30(11):1130-44. doi: 10.1089/AID.2013.0206. Epub 2014 Apr 9.


Structure of an HIV-1-neutralizing antibody target, the lipid-bound gp41 envelope membrane proximal region trimer.

Reardon PN, Sage H, Dennison SM, Martin JW, Donald BR, Alam SM, Haynes BF, Spicer LD.

Proc Natl Acad Sci U S A. 2014 Jan 28;111(4):1391-6. doi: 10.1073/pnas.1309842111. Epub 2014 Jan 13.


Comparative immunogenicity of HIV-1 gp160, gp140 and gp120 expressed by live attenuated newcastle disease virus vector.

Khattar SK, Samal S, LaBranche CC, Montefiori DC, Collins PL, Samal SK.

PLoS One. 2013 Oct 1;8(10):e78521. doi: 10.1371/journal.pone.0078521. eCollection 2013. Erratum in: PLoS One. 2014;9(1). doi:10.1371/annotation/670112f8-b4fd-4622-8a8c-203dc647f807.


Bovine papillomavirus-like particles presenting conserved epitopes from membrane-proximal external region of HIV-1 gp41 induced mucosal and systemic antibodies.

Zhai Y, Zhong Z, Zariffard M, Spear GT, Qiao L.

Vaccine. 2013 Nov 4;31(46):5422-9. doi: 10.1016/j.vaccine.2013.09.003. Epub 2013 Sep 19.


Forced virus evolution reveals functional crosstalk between the disulfide bonded region and membrane proximal ectodomain region of HIV-1 gp41.

Khasawneh AI, Laumaea A, Harrison DN, Bellamy-McIntyre AK, Drummer HE, Poumbourios P.

Retrovirology. 2013 Apr 23;10:44. doi: 10.1186/1742-4690-10-44.


HIV-1 envelope glycoprotein trimers display open quaternary conformation when bound to the gp41 membrane-proximal external-region-directed broadly neutralizing antibody Z13e1.

Harris AK, Bartesaghi A, Milne JL, Subramaniam S.

J Virol. 2013 Jun;87(12):7191-6. doi: 10.1128/JVI.03284-12. Epub 2013 Apr 17.


A gp41 MPER-specific llama VHH requires a hydrophobic CDR3 for neutralization but not for antigen recognition.

Lutje Hulsik D, Liu YY, Strokappe NM, Battella S, El Khattabi M, McCoy LE, Sabin C, Hinz A, Hock M, Macheboeuf P, Bonvin AM, Langedijk JP, Davis D, Forsman Quigley A, Aasa-Chapman MM, Seaman MS, Ramos A, Poignard P, Favier A, Simorre JP, Weiss RA, Verrips CT, Weissenhorn W, Rutten L.

PLoS Pathog. 2013 Mar;9(3):e1003202. doi: 10.1371/journal.ppat.1003202. Epub 2013 Mar 7.


Prospects for prophylactic hepatitis C vaccines based on virus-like particles.

Beaumont E, Roingeard P.

Hum Vaccin Immunother. 2013 May;9(5):1112-8. doi: 10.4161/hv.23900. Epub 2013 Feb 13. Review.


Live attenuated rubella viral vectors stably express HIV and SIV vaccine antigens while reaching high titers.

Virnik K, Ni Y, Berkower I.

Vaccine. 2012 Aug 10;30(37):5453-8. doi: 10.1016/j.vaccine.2012.06.074. Epub 2012 Jul 6.


Induction of antibodies in rhesus macaques that recognize a fusion-intermediate conformation of HIV-1 gp41.

Dennison SM, Sutherland LL, Jaeger FH, Anasti KM, Parks R, Stewart S, Bowman C, Xia SM, Zhang R, Shen X, Scearce RM, Ofek G, Yang Y, Kwong PD, Santra S, Liao HX, Tomaras G, Letvin NL, Chen B, Alam SM, Haynes BF.

PLoS One. 2011;6(11):e27824. doi: 10.1371/journal.pone.0027824. Epub 2011 Nov 30.


Structure-based design of a protein immunogen that displays an HIV-1 gp41 neutralizing epitope.

Stanfield RL, Julien JP, Pejchal R, Gach JS, Zwick MB, Wilson IA.

J Mol Biol. 2011 Dec 2;414(3):460-76. doi: 10.1016/j.jmb.2011.10.014. Epub 2011 Oct 15.


The role of amino acid changes in the human immunodeficiency virus type 1 transmembrane domain in antibody binding and neutralization.

Lovelace E, Xu H, Blish CA, Strong R, Overbaugh J.

Virology. 2011 Dec 20;421(2):235-44. doi: 10.1016/j.virol.2011.09.032. Epub 2011 Oct 24.


Induction of HIV neutralizing antibodies against the MPER of the HIV envelope protein by HA/gp41 chimeric protein-based DNA and VLP vaccines.

Ye L, Wen Z, Dong K, Wang X, Bu Z, Zhang H, Compans RW, Yang C.

PLoS One. 2011;6(5):e14813. doi: 10.1371/journal.pone.0014813. Epub 2011 May 19.


Hepatitis B virus surface antigen assembly function persists when entire transmembrane domains 1 and 3 are replaced by a heterologous transmembrane sequence.

Berkower I, Spadaccini A, Chen H, Al-Awadi D, Muller J, Gao Y, Feigelstock D, Virnik K, Ni Y.

J Virol. 2011 Mar;85(5):2439-48. doi: 10.1128/JVI.02061-10. Epub 2010 Dec 22.


Structure-based vaccine design in HIV: blind men and the elephant?

Pejchal R, Wilson IA.

Curr Pharm Des. 2010;16(33):3744-53. Review.


Rational antibody-based HIV-1 vaccine design: current approaches and future directions.

Walker LM, Burton DR.

Curr Opin Immunol. 2010 Jun;22(3):358-66. doi: 10.1016/j.coi.2010.02.012. Epub 2010 Mar 17. Review.


Prolonged exposure of the HIV-1 gp41 membrane proximal region with L669S substitution.

Shen X, Dennison SM, Liu P, Gao F, Jaeger F, Montefiori DC, Verkoczy L, Haynes BF, Alam SM, Tomaras GD.

Proc Natl Acad Sci U S A. 2010 Mar 30;107(13):5972-7. doi: 10.1073/pnas.0912381107. Epub 2010 Mar 15.

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