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Results: 1 to 20 of 62

1.

Structure-functional prediction and analysis of cancer mutation effects in protein kinases.

Dixit A, Verkhivker GM.

Comput Math Methods Med. 2014;2014:653487. doi: 10.1155/2014/653487. Epub 2014 Apr 8.

PMID:
24817905
[PubMed - in process]
Free PMC Article
2.

Accelerated and Increased Joint Damage in Young Mice with Global Inactivation of Mitogen-Inducible Gene 6 (MIG-6) after Ligament and Meniscus Injury.

Joiner DM, Less KD, Van Wieren EM, Zhang YW, Hess D, Williams BO.

Arthritis Res Ther. 2014 Mar 27;16(2):R81. [Epub ahead of print]

PMID:
24670222
[PubMed - as supplied by publisher]
Free PMC Article
3.

A graph theoretic approach to utilizing protein structure to identify non-random somatic mutations.

Ryslik GA, Cheng Y, Cheung KH, Modis Y, Zhao H.

BMC Bioinformatics. 2014 Mar 26;15:86. doi: 10.1186/1471-2105-15-86.

PMID:
24669769
[PubMed - in process]
Free PMC Article
4.

Integrated genomic characterization reveals novel, therapeutically relevant drug targets in FGFR and EGFR pathways in sporadic intrahepatic cholangiocarcinoma.

Borad MJ, Champion MD, Egan JB, Liang WS, Fonseca R, Bryce AH, McCullough AE, Barrett MT, Hunt K, Patel MD, Young SW, Collins JM, Silva AC, Condjella RM, Block M, McWilliams RR, Lazaridis KN, Klee EW, Bible KC, Harris P, Oliver GR, Bhavsar JD, Nair AA, Middha S, Asmann Y, Kocher JP, Schahl K, Kipp BR, Barr Fritcher EG, Baker A, Aldrich J, Kurdoglu A, Izatt T, Christoforides A, Cherni I, Nasser S, Reiman R, Phillips L, McDonald J, Adkins J, Mastrian SD, Placek P, Watanabe AT, Lobello J, Han H, Von Hoff D, Craig DW, Stewart AK, Carpten JD.

PLoS Genet. 2014 Feb 13;10(2):e1004135. doi: 10.1371/journal.pgen.1004135. eCollection 2014 Feb.

PMID:
24550739
[PubMed - in process]
Free PMC Article
5.

Screening and discovery of nitro-benzoxadiazole compounds activating epidermal growth factor receptor (EGFR) in cancer cells.

Sakanyan V, Angelini M, Le Béchec M, Lecocq MF, Benaiteau F, Rousseau B, Gyulkhandanyan A, Gyulkhandanyan L, Logé C, Reiter E, Roussakis C, Fleury F.

Sci Rep. 2014 Feb 5;4:3977. doi: 10.1038/srep03977.

PMID:
24496106
[PubMed - in process]
Free PMC Article
6.

EGFR lung cancer mutants get specialized.

Littlefield P, Jura N.

Proc Natl Acad Sci U S A. 2013 Sep 17;110(38):15169-70. doi: 10.1073/pnas.1314719110. Epub 2013 Sep 10. No abstract available.

PMID:
24023066
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

The relative expression of Mig6 and EGFR is associated with resistance to EGFR kinase inhibitors.

Chang X, Izumchenko E, Solis LM, Kim MS, Chatterjee A, Ling S, Monitto CL, Harari PM, Hidalgo M, Goodman SN, Wistuba II, Bedi A, Sidransky D.

PLoS One. 2013 Jul 31;8(7):e68966. doi: 10.1371/journal.pone.0068966. Print 2013.

PMID:
23935914
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Transitions to catalytically inactive conformations in EGFR kinase.

Shan Y, Arkhipov A, Kim ET, Pan AC, Shaw DE.

Proc Natl Acad Sci U S A. 2013 Apr 30;110(18):7270-5. doi: 10.1073/pnas.1220843110. Epub 2013 Apr 1.

PMID:
23576739
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Glucocorticoid-induced suppression of β-cell proliferation is mediated by Mig6.

Colvin ES, Ma HY, Chen YC, Hernandez AM, Fueger PT.

Endocrinology. 2013 Mar;154(3):1039-46. doi: 10.1210/en.2012-1923. Epub 2013 Feb 5.

PMID:
23384834
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Ack1: activation and regulation by allostery.

Gajiwala KS, Maegley K, Ferre R, He YA, Yu X.

PLoS One. 2013;8(1):e53994. doi: 10.1371/journal.pone.0053994. Epub 2013 Jan 14.

PMID:
23342057
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Mitogen-inducible gene 6 triggers apoptosis and exacerbates ER stress-induced β-cell death.

Chen YC, Colvin ES, Maier BF, Mirmira RG, Fueger PT.

Mol Endocrinol. 2013 Jan;27(1):162-71. doi: 10.1210/me.2012-1174. Epub 2012 Nov 30.

PMID:
23204325
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Platelet-rich plasma greatly potentiates insulin-induced adipogenic differentiation of human adipose-derived stem cells through a serine/threonine kinase Akt-dependent mechanism and promotes clinical fat graft maintenance.

Cervelli V, Scioli MG, Gentile P, Doldo E, Bonanno E, Spagnoli LG, Orlandi A.

Stem Cells Transl Med. 2012 Mar;1(3):206-20. doi: 10.5966/sctm.2011-0052. Epub 2012 Mar 7.

PMID:
23197780
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Erlotinib binds both inactive and active conformations of the EGFR tyrosine kinase domain.

Park JH, Liu Y, Lemmon MA, Radhakrishnan R.

Biochem J. 2012 Dec 15;448(3):417-23. doi: 10.1042/BJ20121513.

PMID:
23101586
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Protein tyrosine kinase regulation by ubiquitination: critical roles of Cbl-family ubiquitin ligases.

Mohapatra B, Ahmad G, Nadeau S, Zutshi N, An W, Scheffe S, Dong L, Feng D, Goetz B, Arya P, Bailey TA, Palermo N, Borgstahl GE, Natarajan A, Raja SM, Naramura M, Band V, Band H.

Biochim Biophys Acta. 2013 Jan;1833(1):122-39. doi: 10.1016/j.bbamcr.2012.10.010. Epub 2012 Oct 17. Review.

PMID:
23085373
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Mig6 is a sensor of EGF receptor inactivation that directly activates c-Abl to induce apoptosis during epithelial homeostasis.

Hopkins S, Linderoth E, Hantschel O, Suarez-Henriques P, Pilia G, Kendrick H, Smalley MJ, Superti-Furga G, Ferby I.

Dev Cell. 2012 Sep 11;23(3):547-59. doi: 10.1016/j.devcel.2012.08.001.

PMID:
22975324
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Cancer-type regulation of MIG-6 expression by inhibitors of methylation and histone deacetylation.

Zhang YW, Staal B, Dykema KJ, Furge KA, Vande Woude GF.

PLoS One. 2012;7(6):e38955. doi: 10.1371/journal.pone.0038955. Epub 2012 Jun 12.

PMID:
22701735
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Temporal resolution of autophosphorylation for normal and oncogenic forms of EGFR and differential effects of gefitinib.

Kim Y, Li Z, Apetri M, Luo B, Settleman JE, Anderson KS.

Biochemistry. 2012 Jun 26;51(25):5212-22. doi: 10.1021/bi300476v. Epub 2012 Jun 13.

PMID:
22657099
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Chk1 phosphorylates the tumour suppressor Mig-6, regulating the activation of EGF signalling.

Liu N, Matsumoto M, Kitagawa K, Kotake Y, Suzuki S, Shirasawa S, Nakayama KI, Nakanishi M, Niida H, Kitagawa M.

EMBO J. 2012 May 16;31(10):2365-77. doi: 10.1038/emboj.2012.88. Epub 2012 Apr 13.

PMID:
22505024
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Quantitative proteomic profiling identifies protein correlates to EGFR kinase inhibition.

Kani K, Faca VM, Hughes LD, Zhang W, Fang Q, Shahbaba B, Luethy R, Erde J, Schmidt J, Pitteri SJ, Zhang Q, Katz JE, Gross ME, Plevritis SK, McIntosh MW, Jain A, Hanash S, Agus DB, Mallick P.

Mol Cancer Ther. 2012 May;11(5):1071-81. doi: 10.1158/1535-7163.MCT-11-0852. Epub 2012 Mar 12.

PMID:
22411897
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Biophysical and mechanistic insights into novel allosteric inhibitor of spleen tyrosine kinase.

Hall J, Aulabaugh A, Rajamohan F, Liu S, Kaila N, Wan ZK, Ryan M, Magyar R, Qiu X.

J Biol Chem. 2012 Mar 2;287(10):7717-27. doi: 10.1074/jbc.M111.311993. Epub 2012 Jan 4.

PMID:
22219190
[PubMed - indexed for MEDLINE]
Free PMC Article

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