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Results: 16

Cited In for PubMed (Select 18027916)


Acid sphingomyelinase inhibition protects mice from lung edema and lethal Staphylococcus aureus sepsis.

Peng H, Li C, Kadow S, Henry BD, Steinmann J, Becker KA, Riehle A, Beckmann N, Wilker B, Li PL, Pritts T, Edwards MJ, Zhang Y, Gulbins E, Grassmé H.

J Mol Med (Berl). 2015 Jun;93(6):675-89. doi: 10.1007/s00109-014-1246-y. Epub 2015 Jan 25.


Targeting (cellular) lysosomal acid ceramidase by B13: design, synthesis and evaluation of novel DMG-B13 ester prodrugs.

Bai A, Szulc ZM, Bielawski J, Pierce JS, Rembiesa B, Terzieva S, Mao C, Xu R, Wu B, Clarke CJ, Newcomb B, Liu X, Norris J, Hannun YA, Bielawska A.

Bioorg Med Chem. 2014 Dec 15;22(24):6933-44. doi: 10.1016/j.bmc.2014.10.025. Epub 2014 Oct 22.


Inhibition of acid sphingomyelinase by tricyclic antidepressants and analogons.

Beckmann N, Sharma D, Gulbins E, Becker KA, Edelmann B.

Front Physiol. 2014 Sep 2;5:331. doi: 10.3389/fphys.2014.00331. eCollection 2014. Review.


Sphingolipids and mitochondrial function in budding yeast.

Spincemaille P, Matmati N, Hannun YA, Cammue BP, Thevissen K.

Biochim Biophys Acta. 2014 Oct;1840(10):3131-7. doi: 10.1016/j.bbagen.2014.06.015. Epub 2014 Jun 25.


Computational approaches to analyse and predict small molecule transport and distribution at cellular and subcellular levels.

Min KA, Zhang X, Yu JY, Rosania GR.

Biopharm Drug Dispos. 2014 Jan;35(1):15-32. doi: 10.1002/bdd.1879. Epub 2013 Dec 10. Review.


Ceramide mediates lung fibrosis in cystic fibrosis.

Ziobro R, Henry B, Edwards MJ, Lentsch AB, Gulbins E.

Biochem Biophys Res Commun. 2013 May 17;434(4):705-9. doi: 10.1016/j.bbrc.2013.03.032. Epub 2013 Mar 21.


Lipid storage disorders block lysosomal trafficking by inhibiting a TRP channel and lysosomal calcium release.

Shen D, Wang X, Li X, Zhang X, Yao Z, Dibble S, Dong XP, Yu T, Lieberman AP, Showalter HD, Xu H.

Nat Commun. 2012 Mar 13;3:731. doi: 10.1038/ncomms1735.


Differential regulation of acid sphingomyelinase in macrophages stimulated with oxidized low-density lipoprotein (LDL) and oxidized LDL immune complexes: role in phagocytosis and cytokine release.

Truman JP, Al Gadban MM, Smith KJ, Jenkins RW, Mayroo N, Virella G, Lopes-Virella MF, Bielawska A, Hannun YA, Hammad SM.

Immunology. 2012 May;136(1):30-45. doi: 10.1111/j.1365-2567.2012.03552.x.


Identification of novel functional inhibitors of acid sphingomyelinase.

Kornhuber J, Muehlbacher M, Trapp S, Pechmann S, Friedl A, Reichel M, Mühle C, Terfloth L, Groemer TW, Spitzer GM, Liedl KR, Gulbins E, Tripal P.

PLoS One. 2011;6(8):e23852. doi: 10.1371/journal.pone.0023852. Epub 2011 Aug 31.


Lipid raft redox signaling: molecular mechanisms in health and disease.

Jin S, Zhou F, Katirai F, Li PL.

Antioxid Redox Signal. 2011 Aug 15;15(4):1043-83. doi: 10.1089/ars.2010.3619. Epub 2011 May 11. Review.


Mechanisms of amine accumulation in, and egress from, lysosomes.

Goldman SD, Funk RS, Rajewski RA, Krise JP.

Bioanalysis. 2009 Nov;1(8):1445-59. doi: 10.4155/bio.09.128. Review.


Acidic sphingomyelinase controls hepatic stellate cell activation and in vivo liver fibrogenesis.

Moles A, Tarrats N, Morales A, Domínguez M, Bataller R, Caballería J, García-Ruiz C, Fernández-Checa JC, Marí M.

Am J Pathol. 2010 Sep;177(3):1214-24. doi: 10.2353/ajpath.2010.091257. Epub 2010 Jul 22.


The role of sphingolipids and ceramide in pulmonary inflammation in cystic fibrosis.

Becker KA, Riethmüller J, Zhang Y, Gulbins E.

Open Respir Med J. 2010 Mar 30;4:39-47. doi: 10.2174/1874306401004020039.


Unbiased probing of the entire hepatitis C virus life cycle identifies clinical compounds that target multiple aspects of the infection.

Gastaminza P, Whitten-Bauer C, Chisari FV.

Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):291-6. doi: 10.1073/pnas.0912966107. Epub 2009 Dec 7.


Combining chemical genomics screens in yeast to reveal spectrum of effects of chemical inhibition of sphingolipid biosynthesis.

Kemmer D, McHardy LM, Hoon S, Rebérioux D, Giaever G, Nislow C, Roskelley CD, Roberge M.

BMC Microbiol. 2009 Jan 14;9:9. doi: 10.1186/1471-2180-9-9.


Quantitative modeling of selective lysosomal targeting for drug design.

Trapp S, Rosania GR, Horobin RW, Kornhuber J.

Eur Biophys J. 2008 Oct;37(8):1317-28. doi: 10.1007/s00249-008-0338-4. Epub 2008 May 27.

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