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Items: 1 to 20 of 21


Modal affinities of endplate acetylcholine receptors caused by loop C mutations.

Vij R, Purohit P, Auerbach A.

J Gen Physiol. 2015 Nov;146(5):375-86. doi: 10.1085/jgp.201511503.


Analyzing and Quantifying the Gain-of-Function Enhancement of IP3 Receptor Gating by Familial Alzheimer's Disease-Causing Mutants in Presenilins.

Mak DO, Cheung KH, Toglia P, Foskett JK, Ullah G.

PLoS Comput Biol. 2015 Oct 6;11(10):e1004529. doi: 10.1371/journal.pcbi.1004529. eCollection 2015 Oct.


Inositol 1,4,5-trisphosphate receptors in the endoplasmic reticulum: A single-channel point of view.

Mak DO, Foskett JK.

Cell Calcium. 2015 Jul;58(1):67-78. doi: 10.1016/j.ceca.2014.12.008. Epub 2014 Dec 18. Review.


A deterministic model predicts the properties of stochastic calcium oscillations in airway smooth muscle cells.

Cao P, Tan X, Donovan G, Sanderson MJ, Sneyd J.

PLoS Comput Biol. 2014 Aug 14;10(8):e1003783. doi: 10.1371/journal.pcbi.1003783. eCollection 2014 Aug.


Multiscale modelling of saliva secretion.

Sneyd J, Crampin E, Yule D.

Math Biosci. 2014 Nov;257:69-79. doi: 10.1016/j.mbs.2014.06.017. Epub 2014 Jul 8.


Characterization of ryanodine receptor type 1 single channel activity using "on-nucleus" patch clamp.

Wagner LE 2nd, Groom LA, Dirksen RT, Yule DI.

Cell Calcium. 2014 Aug;56(2):96-107. doi: 10.1016/j.ceca.2014.05.004. Epub 2014 Jun 6.


Patch-clamp electrophysiology of intracellular Ca2+ channels.

Mak DO, Vais H, Cheung KH, Foskett JK.

Cold Spring Harb Protoc. 2013 Sep 1;2013(9):787-97. doi: 10.1101/pdb.top066217.


A kinetic model for type I and II IP3R accounting for mode changes.

Siekmann I, Wagner LE 2nd, Yule D, Crampin EJ, Sneyd J.

Biophys J. 2012 Aug 22;103(4):658-68. doi: 10.1016/j.bpj.2012.07.016.


A data-driven model of a modal gated ion channel: the inositol 1,4,5-trisphosphate receptor in insect Sf9 cells.

Ullah G, Mak DO, Pearson JE.

J Gen Physiol. 2012 Aug;140(2):159-73. doi: 10.1085/jgp.201110753.


Differential regulation of the InsP₃ receptor type-1 and -2 single channel properties by InsP₃, Ca²⁺ and ATP.

Wagner LE 2nd, Yule DI.

J Physiol. 2012 Jul 15;590(14):3245-59. doi: 10.1113/jphysiol.2012.228320. Epub 2012 Apr 30.


Enhanced ROS generation mediated by Alzheimer's disease presenilin regulation of InsP3R Ca2+ signaling.

Müller M, Cheung KH, Foskett JK.

Antioxid Redox Signal. 2011 Apr 1;14(7):1225-35. doi: 10.1089/ars.2010.3421. Epub 2010 Dec 2.


Inositol trisphosphate receptor Ca2+ release channels in neurological diseases.

Foskett JK.

Pflugers Arch. 2010 Jul;460(2):481-94. doi: 10.1007/s00424-010-0826-0. Epub 2010 Apr 10. Review.


Stationary gating of GluN1/GluN2B receptors in intact membrane patches.

Amico-Ruvio SA, Popescu GK.

Biophys J. 2010 Apr 7;98(7):1160-9. doi: 10.1016/j.bpj.2009.12.4276.


Gain-of-function enhancement of IP3 receptor modal gating by familial Alzheimer's disease-linked presenilin mutants in human cells and mouse neurons.

Cheung KH, Mei L, Mak DO, Hayashi I, Iwatsubo T, Kang DE, Foskett JK.

Sci Signal. 2010 Mar 23;3(114):ra22. doi: 10.1126/scisignal.2000818.


ER calcium and Alzheimer's disease: in a state of flux.

Mattson MP.

Sci Signal. 2010 Mar 23;3(114):pe10. doi: 10.1126/scisignal.3114pe10. Review.


Ca(2+) puffs originate from preestablished stable clusters of inositol trisphosphate receptors.

Smith IF, Wiltgen SM, Shuai J, Parker I.

Sci Signal. 2009 Nov 24;2(98):ra77. doi: 10.1126/scisignal.2000466.


A simple sequential-binding model for calcium puffs.

Swaminathan D, Ullah G, Jung P.

Chaos. 2009 Sep;19(3):037109. doi: 10.1063/1.3152227. Erratum in: Chaos. 2010 Mar;20(1):019901.


A kinetic model of the inositol trisphosphate receptor based on single-channel data.

Gin E, Falcke M, Wagner LE 2nd, Yule DI, Sneyd J.

Biophys J. 2009 May 20;96(10):4053-62. doi: 10.1016/j.bpj.2008.12.3964.


Imaging the quantal substructure of single IP3R channel activity during Ca2+ puffs in intact mammalian cells.

Smith IF, Parker I.

Proc Natl Acad Sci U S A. 2009 Apr 14;106(15):6404-9. doi: 10.1073/pnas.0810799106. Epub 2009 Mar 30.

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