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Results: 16

Cited In for PubMed (Select 17947987)

1.

Covalent docking of large libraries for the discovery of chemical probes.

London N, Miller RM, Krishnan S, Uchida K, Irwin JJ, Eidam O, Gibold L, Cimermančič P, Bonnet R, Shoichet BK, Taunton J.

Nat Chem Biol. 2014 Dec;10(12):1066-72. doi: 10.1038/nchembio.1666. Epub 2014 Oct 26. Erratum in: Nat Chem Biol. 2015 Mar;11(3):235.

PMID:
25344815
2.

TIPE3 is the transfer protein of lipid second messengers that promote cancer.

Fayngerts SA, Wu J, Oxley CL, Liu X, Vourekas A, Cathopoulis T, Wang Z, Cui J, Liu S, Sun H, Lemmon MA, Zhang L, Shi Y, Chen YH.

Cancer Cell. 2014 Oct 13;26(4):465-78. doi: 10.1016/j.ccr.2014.07.025. Epub 2014 Sep 18.

PMID:
25242044
3.

Phosphoinositide 3-kinase δ gene mutation predisposes to respiratory infection and airway damage.

Angulo I, Vadas O, Garçon F, Banham-Hall E, Plagnol V, Leahy TR, Baxendale H, Coulter T, Curtis J, Wu C, Blake-Palmer K, Perisic O, Smyth D, Maes M, Fiddler C, Juss J, Cilliers D, Markelj G, Chandra A, Farmer G, Kielkowska A, Clark J, Kracker S, Debré M, Picard C, Pellier I, Jabado N, Morris JA, Barcenas-Morales G, Fischer A, Stephens L, Hawkins P, Barrett JC, Abinun M, Clatworthy M, Durandy A, Doffinger R, Chilvers ER, Cant AJ, Kumararatne D, Okkenhaug K, Williams RL, Condliffe A, Nejentsev S.

Science. 2013 Nov 15;342(6160):866-71. doi: 10.1126/science.1243292. Epub 2013 Oct 17.

4.

G protein-coupled receptor-mediated activation of p110β by Gβγ is required for cellular transformation and invasiveness.

Dbouk HA, Vadas O, Shymanets A, Burke JE, Salamon RS, Khalil BD, Barrett MO, Waldo GL, Surve C, Hsueh C, Perisic O, Harteneck C, Shepherd PR, Harden TK, Smrcka AV, Taussig R, Bresnick AR, Nürnberg B, Williams RL, Backer JM.

Sci Signal. 2012 Dec 4;5(253):ra89. doi: 10.1126/scisignal.2003264.

5.

Dynamic steps in receptor tyrosine kinase mediated activation of class IA phosphoinositide 3-kinases (PI3K) captured by H/D exchange (HDX-MS).

Burke JE, Williams RL.

Adv Biol Regul. 2013 Jan;53(1):97-110. doi: 10.1016/j.jbior.2012.09.005. Epub 2012 Sep 13.

6.

Integrin α9β1 in airway smooth muscle suppresses exaggerated airway narrowing.

Chen C, Kudo M, Rutaganira F, Takano H, Lee C, Atakilit A, Robinett KS, Uede T, Wolters PJ, Shokat KM, Huang X, Sheppard D.

J Clin Invest. 2012 Aug;122(8):2916-27. doi: 10.1172/JCI60387. Epub 2012 Jul 9.

7.

Direct modification and activation of a nuclear receptor-PIP₂ complex by the inositol lipid kinase IPMK.

Blind RD, Suzawa M, Ingraham HA.

Sci Signal. 2012 Jun 19;5(229):ra44. doi: 10.1126/scisignal.2003111.

8.

Identification of small molecule inhibitors of phosphatidylinositol 3-kinase and autophagy.

Farkas T, Daugaard M, Jäättelä M.

J Biol Chem. 2011 Nov 11;286(45):38904-12. doi: 10.1074/jbc.M111.269134. Epub 2011 Sep 19.

9.

Dynamics of the phosphoinositide 3-kinase p110δ interaction with p85α and membranes reveals aspects of regulation distinct from p110α.

Burke JE, Vadas O, Berndt A, Finegan T, Perisic O, Williams RL.

Structure. 2011 Aug 10;19(8):1127-37. doi: 10.1016/j.str.2011.06.003.

10.

Structure of lipid kinase p110β/p85β elucidates an unusual SH2-domain-mediated inhibitory mechanism.

Zhang X, Vadas O, Perisic O, Anderson KE, Clark J, Hawkins PT, Stephens LR, Williams RL.

Mol Cell. 2011 Mar 4;41(5):567-78. doi: 10.1016/j.molcel.2011.01.026.

11.

Inositol polyphosphate multikinase is a physiologic PI3-kinase that activates Akt/PKB.

Maag D, Maxwell MJ, Hardesty DA, Boucher KL, Choudhari N, Hanno AG, Ma JF, Snowman AS, Pietropaoli JW, Xu R, Storm PB, Saiardi A, Snyder SH, Resnick AC.

Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1391-6. doi: 10.1073/pnas.1017831108. Epub 2011 Jan 10.

12.

Synthesis and evaluation of indazole based analog sensitive Akt inhibitors.

Okuzumi T, Ducker GS, Zhang C, Aizenstein B, Hoffman R, Shokat KM.

Mol Biosyst. 2010 Aug;6(8):1389-402. doi: 10.1039/c003917a. Epub 2010 Jun 28.

13.

Discovery of dual inhibitors of the immune cell PI3Ks p110delta and p110gamma: a prototype for new anti-inflammatory drugs.

Williams O, Houseman BT, Kunkel EJ, Aizenstein B, Hoffman R, Knight ZA, Shokat KM.

Chem Biol. 2010 Feb 26;17(2):123-34. doi: 10.1016/j.chembiol.2010.01.010.

14.

Somatic mutations in p85alpha promote tumorigenesis through class IA PI3K activation.

Jaiswal BS, Janakiraman V, Kljavin NM, Chaudhuri S, Stern HM, Wang W, Kan Z, Dbouk HA, Peters BA, Waring P, Dela Vega T, Kenski DM, Bowman KK, Lorenzo M, Li H, Wu J, Modrusan Z, Stinson J, Eby M, Yue P, Kaminker JS, de Sauvage FJ, Backer JM, Seshagiri S.

Cancer Cell. 2009 Dec 8;16(6):463-74. doi: 10.1016/j.ccr.2009.10.016.

15.

Phospholipase d promotes lipid microdomain-associated signaling events in mast cells.

Lisboa FA, Peng Z, Combs CA, Beaven MA.

J Immunol. 2009 Oct 15;183(8):5104-12. doi: 10.4049/jimmunol.0802728. Epub 2009 Sep 30.

16.

Discovery of drug-resistant and drug-sensitizing mutations in the oncogenic PI3K isoform p110 alpha.

Zunder ER, Knight ZA, Houseman BT, Apsel B, Shokat KM.

Cancer Cell. 2008 Aug 12;14(2):180-92. doi: 10.1016/j.ccr.2008.06.014.

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