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Results: 1 to 20 of 31

1.

A proteolytic cascade controls lysosome rupture and necrotic cell death mediated by lysosome-destabilizing adjuvants.

Brojatsch J, Lima H, Kar AK, Jacobson LS, Muehlbauer SM, Chandran K, Diaz-Griffero F.

PLoS One. 2014 Jun 3;9(6):e95032. doi: 10.1371/journal.pone.0095032. eCollection 2014.

PMID:
24893007
[PubMed - in process]
Free PMC Article
2.

Selective inhibitor of endosomal trafficking pathways exploited by multiple toxins and viruses.

Gillespie EJ, Ho CL, Balaji K, Clemens DL, Deng G, Wang YE, Elsaesser HJ, Tamilselvam B, Gargi A, Dixon SD, France B, Chamberlain BT, Blanke SR, Cheng G, de la Torre JC, Brooks DG, Jung ME, Colicelli J, Damoiseaux R, Bradley KA.

Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):E4904-12. doi: 10.1073/pnas.1302334110. Epub 2013 Nov 4.

PMID:
24191014
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Calpain-dependent cytoskeletal rearrangement exploited for anthrax toxin endocytosis.

Jeong SY, Martchenko M, Cohen SN.

Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):E4007-15. doi: 10.1073/pnas.1316852110. Epub 2013 Oct 1.

PMID:
24085852
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Identification of novel host-targeted compounds that protect from anthrax lethal toxin-induced cell death.

Slater LH, Hett EC, Mark K, Chumbler NM, Patel D, Lacy DB, Collier RJ, Hung DT.

ACS Chem Biol. 2013 Apr 19;8(4):812-22. doi: 10.1021/cb300555n. Epub 2013 Feb 4.

PMID:
23343607
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Cathepsin-mediated necrosis controls the adaptive immune response by Th2 (T helper type 2)-associated adjuvants.

Jacobson LS, Lima H Jr, Goldberg MF, Gocheva V, Tsiperson V, Sutterwala FS, Joyce JA, Gapp BV, Blomen VA, Chandran K, Brummelkamp TR, Diaz-Griffero F, Brojatsch J.

J Biol Chem. 2013 Mar 15;288(11):7481-91. doi: 10.1074/jbc.M112.400655. Epub 2013 Jan 7.

PMID:
23297415
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Activation of the Nlrp1b inflammasome by reduction of cytosolic ATP.

Liao KC, Mogridge J.

Infect Immun. 2013 Feb;81(2):570-9. doi: 10.1128/IAI.01003-12. Epub 2012 Dec 10.

PMID:
23230290
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Deubiquitinases regulate the activity of caspase-1 and interleukin-1β secretion via assembly of the inflammasome.

Lopez-Castejon G, Luheshi NM, Compan V, High S, Whitehead RC, Flitsch S, Kirov A, Prudovsky I, Swanton E, Brough D.

J Biol Chem. 2013 Jan 25;288(4):2721-33. doi: 10.1074/jbc.M112.422238. Epub 2012 Dec 3.

PMID:
23209292
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Cellular adaptation to anthrax lethal toxin-induced mitochondrial cholesterol enrichment, hyperpolarization, and reactive oxygen species generation through downregulating MLN64 in macrophages.

Ha SD, Park S, Han CY, Nguyen ML, Kim SO.

Mol Cell Biol. 2012 Dec;32(23):4846-60. doi: 10.1128/MCB.00494-12. Epub 2012 Oct 1.

PMID:
23028046
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Suppression of ribosomal function triggers innate immune signaling through activation of the NLRP3 inflammasome.

Vyleta ML, Wong J, Magun BE.

PLoS One. 2012;7(5):e36044. doi: 10.1371/journal.pone.0036044. Epub 2012 May 14.

PMID:
22606244
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Proteolytic processing of Nlrp1b is required for inflammasome activity.

Frew BC, Joag VR, Mogridge J.

PLoS Pathog. 2012;8(4):e1002659. doi: 10.1371/journal.ppat.1002659. Epub 2012 Apr 19.

PMID:
22536155
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Anthrax lethal factor cleavage of Nlrp1 is required for activation of the inflammasome.

Levinsohn JL, Newman ZL, Hellmich KA, Fattah R, Getz MA, Liu S, Sastalla I, Leppla SH, Moayeri M.

PLoS Pathog. 2012;8(3):e1002638. doi: 10.1371/journal.ppat.1002638. Epub 2012 Mar 29.

PMID:
22479187
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

The inflammasome in host defense.

Chen G, Pedra JH.

Sensors (Basel). 2010;10(1):97-111. doi: 10.3390/s100100097. Epub 2009 Dec 28. Review.

PMID:
22315529
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Immunology in clinic review series; focus on autoinflammatory diseases: inflammasomes: mechanisms of activation.

Mankan AK, Kubarenko A, Hornung V.

Clin Exp Immunol. 2012 Mar;167(3):369-81. doi: 10.1111/j.1365-2249.2011.04534.x. Review.

PMID:
22288580
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Anthrax and the inflammasome.

Moayeri M, Sastalla I, Leppla SH.

Microbes Infect. 2012 May;14(5):392-400. doi: 10.1016/j.micinf.2011.12.005. Epub 2011 Dec 17. Review.

PMID:
22207185
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Regulating caspase-1 during infection: roles of NLRs, AIM2, and ASC.

Case CL.

Yale J Biol Med. 2011 Dec;84(4):333-43. Review.

PMID:
22180671
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

The inflammasomes: molecular effectors of host resistance against bacterial, viral, parasitic, and fungal infections.

Skeldon A, Saleh M.

Front Microbiol. 2011 Feb 17;2:15. doi: 10.3389/fmicb.2011.00015. eCollection 2011.

PMID:
21716947
[PubMed]
Free PMC Article
17.

Varicella-zoster virus infection triggers formation of an interleukin-1β (IL-1β)-processing inflammasome complex.

Nour AM, Reichelt M, Ku CC, Ho MY, Heineman TC, Arvin AM.

J Biol Chem. 2011 May 20;286(20):17921-33. doi: 10.1074/jbc.M110.210575. Epub 2011 Mar 8.

PMID:
21385879
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Auranofin protects against anthrax lethal toxin-induced activation of the Nlrp1b inflammasome.

Newman ZL, Sirianni N, Mawhinney C, Lee MS, Leppla SH, Moayeri M, Johansen LM.

Antimicrob Agents Chemother. 2011 Mar;55(3):1028-35. doi: 10.1128/AAC.00772-10. Epub 2010 Dec 13.

PMID:
21149629
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Anthrax lethal toxin activates the inflammasome in sensitive rat macrophages.

Newman ZL, Crown D, Leppla SH, Moayeri M.

Biochem Biophys Res Commun. 2010 Aug 6;398(4):785-9. doi: 10.1016/j.bbrc.2010.07.039. Epub 2010 Jul 16.

PMID:
20638366
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Proteasome inhibitors prevent caspase-1-mediated disease in rodents challenged with anthrax lethal toxin.

Muehlbauer SM, Lima H Jr, Goldman DL, Jacobson LS, Rivera J, Goldberg MF, Palladino MA, Casadevall A, Brojatsch J.

Am J Pathol. 2010 Aug;177(2):735-43. doi: 10.2353/ajpath.2010.090828. Epub 2010 Jul 1. Erratum in: Am J Pathol. 2010 Oct;177(4):2145.

PMID:
20595632
[PubMed - indexed for MEDLINE]
Free PMC Article

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