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Results: 1 to 20 of 85

1.

Mechanism of action of compound-13: an α1-selective small molecule activator of AMPK.

Hunter RW, Foretz M, Bultot L, Fullerton MD, Deak M, Ross FA, Hawley SA, Shpiro N, Viollet B, Barron D, Kemp BE, Steinberg GR, Hardie DG, Sakamoto K.

Chem Biol. 2014 Jul 17;21(7):866-79. doi: 10.1016/j.chembiol.2014.05.014.

PMID:
25036776
[PubMed - in process]
Free PMC Article
2.

AMPK activation: a therapeutic target for type 2 diabetes?

Coughlan KA, Valentine RJ, Ruderman NB, Saha AK.

Diabetes Metab Syndr Obes. 2014 Jun 24;7:241-53. doi: 10.2147/DMSO.S43731. eCollection 2014. Review.

PMID:
25018645
[PubMed]
Free PMC Article
3.

Metformin: On Ongoing Journey across Diabetes, Cancer Therapy and Prevention.

Pulito C, Sanli T, Rana P, Muti P, Blandino G, Strano S.

Metabolites. 2013 Nov 7;3(4):1051-75. doi: 10.3390/metabo3041051.

PMID:
24958265
[PubMed]
Free PMC Article
4.

Mechanisms of regulation of SNF1/AMPK/SnRK1 protein kinases.

Crozet P, Margalha L, Confraria A, Rodrigues A, Martinho C, Adamo M, Elias CA, Baena-González E.

Front Plant Sci. 2014 May 20;5:190. doi: 10.3389/fpls.2014.00190. eCollection 2014. Review.

PMID:
24904600
[PubMed]
Free PMC Article
5.

In silico design for adenosine monophosphate-activated protein kinase agonist from traditional chinese medicine for treatment of metabolic syndromes.

Tang HC, Chen CY.

Evid Based Complement Alternat Med. 2014;2014:928589. doi: 10.1155/2014/928589. Epub 2014 May 11.

PMID:
24899913
[PubMed]
Free PMC Article
6.

AMPK: regulating energy balance at the cellular and whole body levels.

Hardie DG, Ashford ML.

Physiology (Bethesda). 2014 Mar;29(2):99-107. doi: 10.1152/physiol.00050.2013.

PMID:
24583766
[PubMed - in process]
Free PMC Article
7.

DAF-16/FoxO directly regulates an atypical AMP-activated protein kinase gamma isoform to mediate the effects of insulin/IGF-1 signaling on aging in Caenorhabditis elegans.

Tullet JM, Araiz C, Sanders MJ, Au C, Benedetto A, Papatheodorou I, Clark E, Schmeisser K, Jones D, Schuster EF, Thornton JM, Gems D.

PLoS Genet. 2014 Feb 6;10(2):e1004109. doi: 10.1371/journal.pgen.1004109. eCollection 2014 Feb.

PMID:
24516399
[PubMed - in process]
Free PMC Article
8.

A complex containing SNF1-related kinase (SnRK1) and adenosine kinase in Arabidopsis.

Mohannath G, Jackel JN, Lee YH, Buchmann RC, Wang H, Patil V, Adams AK, Bisaro DM.

PLoS One. 2014 Jan 30;9(1):e87592. doi: 10.1371/journal.pone.0087592. eCollection 2014.

PMID:
24498147
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Phosphorylation by Akt within the ST loop of AMPK-α1 down-regulates its activation in tumour cells.

Hawley SA, Ross FA, Gowans GJ, Tibarewal P, Leslie NR, Hardie DG.

Biochem J. 2014 Apr 15;459(2):275-87. doi: 10.1042/BJ20131344.

PMID:
24467442
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

A High Throughput Assay for Discovery of Small Molecules that Bind AMP-activated Protein Kinase (AMPK).

Sinnett SE, Sexton JZ, Brenman JE.

Curr Chem Genomics Transl Med. 2013 Sep 3;7:30-8. doi: 10.2174/2213988501307010030. eCollection 2013.

PMID:
24396733
[PubMed]
Free PMC Article
11.

Synaptic activity and bioenergy homeostasis: implications in brain trauma and neurodegenerative diseases.

Khatri N, Man HY.

Front Neurol. 2013 Dec 11;4:199. doi: 10.3389/fneur.2013.00199. Review.

PMID:
24376435
[PubMed]
Free PMC Article
12.

Structural basis of AMPK regulation by small molecule activators.

Xiao B, Sanders MJ, Carmena D, Bright NJ, Haire LF, Underwood E, Patel BR, Heath RB, Walker PA, Hallen S, Giordanetto F, Martin SR, Carling D, Gamblin SJ.

Nat Commun. 2013;4:3017. doi: 10.1038/ncomms4017.

PMID:
24352254
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

AMP is a true physiological regulator of AMP-activated protein kinase by both allosteric activation and enhancing net phosphorylation.

Gowans GJ, Hawley SA, Ross FA, Hardie DG.

Cell Metab. 2013 Oct 1;18(4):556-66. doi: 10.1016/j.cmet.2013.08.019.

PMID:
24093679
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

An acetylation rheostat for the control of muscle energy homeostasis.

Menzies K, Auwerx J.

J Mol Endocrinol. 2013 Nov 26;51(3):T101-13. doi: 10.1530/JME-13-0140. Print 2013 Dec. Review.

PMID:
23999889
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

In scarcity and abundance: metabolic signals regulating cell growth.

Saad S, Peter M, Dechant R.

Physiology (Bethesda). 2013 Sep;28(5):298-309. doi: 10.1152/physiol.00005.2013. Review.

PMID:
23997189
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

AMPK: a target for drugs and natural products with effects on both diabetes and cancer.

Hardie DG.

Diabetes. 2013 Jul;62(7):2164-72. doi: 10.2337/db13-0368. Review.

PMID:
23801715
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Identification of a novel de novo mutation associated with PRKAG2 cardiac syndrome and early onset of heart failure.

Liu Y, Bai R, Wang L, Zhang C, Zhao R, Wan D, Chen X, Caceres G, Barr D, Barajas-Martinez H, Antzelevitch C, Hu D.

PLoS One. 2013 May 31;8(5):e64603. doi: 10.1371/journal.pone.0064603. Print 2013.

PMID:
23741347
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

LKB1 and AMPK and the cancer-metabolism link - ten years after.

Hardie DG, Alessi DR.

BMC Biol. 2013 Apr 15;11:36. doi: 10.1186/1741-7007-11-36. Review.

PMID:
23587167
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Sumoylation of AMPKβ2 subunit enhances AMP-activated protein kinase activity.

Rubio T, Vernia S, Sanz P.

Mol Biol Cell. 2013 Jun;24(11):1801-11, S1-4. doi: 10.1091/mbc.E12-11-0806. Epub 2013 Apr 3.

PMID:
23552691
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Different characteristics and nucleotide binding properties of inosine monophosphate dehydrogenase (IMPDH) isoforms.

Thomas EC, Gunter JH, Webster JA, Schieber NL, Oorschot V, Parton RG, Whitehead JP.

PLoS One. 2012;7(12):e51096. doi: 10.1371/journal.pone.0051096. Epub 2012 Dec 7.

PMID:
23236438
[PubMed - indexed for MEDLINE]
Free PMC Article

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