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Results: 1 to 20 of 132

1.

The ubiquitin-proteasome system in neurodegenerative diseases: precipitating factor, yet part of the solution.

Dantuma NP, Bott LC.

Front Mol Neurosci. 2014 Jul 31;7:70. doi: 10.3389/fnmol.2014.00070. eCollection 2014. Review.

PMID:
25132814
[PubMed]
Free PMC Article
2.
3.

Polyglutamine-rich suppressors of huntingtin toxicity act upstream of Hsp70 and Sti1 in spatial quality control of amyloid-like proteins.

Wolfe KJ, Ren HY, Trepte P, Cyr DM.

PLoS One. 2014 May 14;9(5):e95914. doi: 10.1371/journal.pone.0095914. eCollection 2014.

PMID:
24828240
[PubMed - in process]
Free PMC Article
4.

Aggregation-prone proteins modulate huntingtin inclusion body formation in yeast.

Kantcheva RB, Mason R, Giorgini F.

PLoS Curr. 2014 Apr 23;6. pii: ecurrents.hd.501008f3051342c9a5c0cd0f3a5bf3a4. doi: 10.1371/currents.hd.501008f3051342c9a5c0cd0f3a5bf3a4.

PMID:
24804153
[PubMed]
Free PMC Article
5.

Top-down proteomics with mass spectrometry imaging: a pilot study towards discovery of biomarkers for neurodevelopmental disorders.

Ye H, Mandal R, Catherman A, Thomas PM, Kelleher NL, Ikonomidou C, Li L.

PLoS One. 2014 Apr 7;9(4):e92831. doi: 10.1371/journal.pone.0092831. eCollection 2014.

PMID:
24710523
[PubMed - in process]
Free PMC Article
6.

Signaling pathways from the endoplasmic reticulum and their roles in disease.

Kadowaki H, Nishitoh H.

Genes (Basel). 2013 Jul 1;4(3):306-33. doi: 10.3390/genes4030306.

PMID:
24705207
[PubMed]
Free PMC Article
7.

ER stress-induced eIF2-alpha phosphorylation underlies sensitivity of striatal neurons to pathogenic huntingtin.

Leitman J, Barak B, Benyair R, Shenkman M, Ashery U, Hartl FU, Lederkremer GZ.

PLoS One. 2014 Mar 3;9(3):e90803. doi: 10.1371/journal.pone.0090803. eCollection 2014.

PMID:
24594939
[PubMed - in process]
Free PMC Article
8.

Ubiquilin-1 overexpression increases the lifespan and delays accumulation of Huntingtin aggregates in the R6/2 mouse model of Huntington's disease.

Safren N, El Ayadi A, Chang L, Terrillion CE, Gould TD, Boehning DF, Monteiro MJ.

PLoS One. 2014 Jan 27;9(1):e87513. doi: 10.1371/journal.pone.0087513. eCollection 2014.

PMID:
24475300
[PubMed - in process]
Free PMC Article
9.

Structural propensities of human ubiquitination sites: accessibility, centrality and local conformation.

Zhou Y, Liu S, Song J, Zhang Z.

PLoS One. 2013 Dec 11;8(12):e83167. doi: 10.1371/journal.pone.0083167. eCollection 2013.

PMID:
24349449
[PubMed - in process]
Free PMC Article
10.

Natural genetic variation determines susceptibility to aggregation or toxicity in a C. elegans model for polyglutamine disease.

Gidalevitz T, Wang N, Deravaj T, Alexander-Floyd J, Morimoto RI.

BMC Biol. 2013 Sep 30;11:100. doi: 10.1186/1741-7007-11-100.

PMID:
24079614
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Huntington's disease: underlying molecular mechanisms and emerging concepts.

Labbadia J, Morimoto RI.

Trends Biochem Sci. 2013 Aug;38(8):378-85. doi: 10.1016/j.tibs.2013.05.003. Epub 2013 Jun 12. Review.

PMID:
23768628
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Tau accumulation activates the unfolded protein response by impairing endoplasmic reticulum-associated degradation.

Abisambra JF, Jinwal UK, Blair LJ, O'Leary JC 3rd, Li Q, Brady S, Wang L, Guidi CE, Zhang B, Nordhues BA, Cockman M, Suntharalingham A, Li P, Jin Y, Atkins CA, Dickey CA.

J Neurosci. 2013 May 29;33(22):9498-507. doi: 10.1523/JNEUROSCI.5397-12.2013.

PMID:
23719816
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Aqueous Extract of Paeonia lactiflora and Paeoniflorin as Aggregation Reducers Targeting Chaperones in Cell Models of Spinocerebellar Ataxia 3.

Chang KH, Chen WL, Lee LC, Lin CH, Kung PJ, Lin TH, Wu YC, Wu YR, Chen YC, Lee-Chen GJ, Chen CM.

Evid Based Complement Alternat Med. 2013;2013:471659. doi: 10.1155/2013/471659. Epub 2013 Feb 25.

PMID:
23533486
[PubMed]
Free PMC Article
14.

Cytosolic proteins lose solubility as amyloid deposits in a transgenic mouse model of Alzheimer-type amyloidosis.

Xu G, Stevens SM Jr, Moore BD, McClung S, Borchelt DR.

Hum Mol Genet. 2013 Jul 15;22(14):2765-74. doi: 10.1093/hmg/ddt121. Epub 2013 Mar 19.

PMID:
23512986
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Aggregation of human S100A8 and S100A9 amyloidogenic proteins perturbs proteostasis in a yeast model.

Eremenko E, Ben-Zvi A, Morozova-Roche LA, Raveh D.

PLoS One. 2013;8(3):e58218. doi: 10.1371/journal.pone.0058218. Epub 2013 Mar 6.

PMID:
23483999
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

NAD+ salvage pathway proteins suppress proteotoxicity in yeast models of neurodegeneration by promoting the clearance of misfolded/oligomerized proteins.

Ocampo A, Liu J, Barrientos A.

Hum Mol Genet. 2013 May 1;22(9):1699-708. doi: 10.1093/hmg/ddt016. Epub 2013 Jan 18.

PMID:
23335597
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Poly-glutamine expanded huntingtin dramatically alters the genome wide binding of HSF1.

Riva L, Koeva M, Yildirim F, Pirhaji L, Dinesh D, Mazor T, Duennwald ML, Fraenkel E.

J Huntingtons Dis. 2012 Jan;1(1):33-45.

PMID:
23293686
[PubMed - in process]
Free PMC Article
18.

Regulation of feedback between protein kinase A and the proteasome system worsens Huntington's disease.

Lin JT, Chang WC, Chen HM, Lai HL, Chen CY, Tao MH, Chern Y.

Mol Cell Biol. 2013 Mar;33(5):1073-84. doi: 10.1128/MCB.01434-12. Epub 2012 Dec 28.

PMID:
23275441
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Large-scale screen for modifiers of ataxin-3-derived polyglutamine-induced toxicity in Drosophila.

VoSSfeldt H, Butzlaff M, PrüSSing K, Ní Chárthaigh RA, Karsten P, Lankes A, Hamm S, Simons M, Adryan B, Schulz JB, Voigt A.

PLoS One. 2012;7(11):e47452. doi: 10.1371/journal.pone.0047452. Epub 2012 Nov 5.

PMID:
23139745
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Fragments of HdhQ150 mutant huntingtin form a soluble oligomer pool that declines with aggregate deposition upon aging.

Marcellin D, Abramowski D, Young D, Richter J, Weiss A, Marcel A, Maassen J, Kauffmann M, Bibel M, Shimshek DR, Faull RL, Bates GP, Kuhn RR, Van der Putten PH, Schmid P, Lotz GP.

PLoS One. 2012;7(9):e44457. doi: 10.1371/journal.pone.0044457. Epub 2012 Sep 12.

PMID:
22984513
[PubMed - indexed for MEDLINE]
Free PMC Article

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