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Targeting translation initiation in breast cancer.

Akcakanat A, Hong DS, Meric-Bernstam F.

Translation (Austin). 2014 Apr 29;2(1):e28968. doi: 10.4161/trla.28968. eCollection 2014. Review.


Transforming Growth Factor-β1 Induced Epithelial Mesenchymal Transition is blocked by a chemical antagonist of translation factor eIF4E.

Smith KA, Zhou B, Avdulov S, Benyumov A, Peterson M, Liu Y, Okon A, Hergert P, Braziunas J, Wagner CR, Borok Z, Bitterman PB.

Sci Rep. 2015 Dec 18;5:18233. doi: 10.1038/srep18233.


Therapeutic interventions to disrupt the protein synthetic machinery in melanoma.

Kardos GR, Robertson GP.

Pigment Cell Melanoma Res. 2015 Sep;28(5):501-19. doi: 10.1111/pcmr.12391.


Phosphorylation of eIF4E Confers Resistance to Cellular Stress and DNA-Damaging Agents through an Interaction with 4E-T: A Rationale for Novel Therapeutic Approaches.

Martínez A, Sesé M, Losa JH, Robichaud N, Sonenberg N, Aasen T, Ramón Y Cajal S.

PLoS One. 2015 Apr 29;10(4):e0123352. doi: 10.1371/journal.pone.0123352. eCollection 2015.


Molecular portraits: the evolution of the concept of transcriptome-based cancer signatures.

Modelska A, Quattrone A, Re A.

Brief Bioinform. 2015 Nov;16(6):1000-7. doi: 10.1093/bib/bbv013. Epub 2015 Mar 31.


eIF4E and eIF4GI have distinct and differential imprints on multiple myeloma's proteome and signaling.

Attar-Schneider O, Pasmanik-Chor M, Tartakover-Matalon S, Drucker L, Lishner M.

Oncotarget. 2015 Feb 28;6(6):4315-29.


mTOR coordinates protein synthesis, mitochondrial activity and proliferation.

Morita M, Gravel SP, Hulea L, Larsson O, Pollak M, St-Pierre J, Topisirovic I.

Cell Cycle. 2015;14(4):473-80. doi: 10.4161/15384101.2014.991572. Review.


eIF4E threshold levels differ in governing normal and neoplastic expansion of mammary stem and luminal progenitor cells.

Avdulov S, Herrera J, Smith K, Peterson M, Gomez-Garcia JR, Beadnell TC, Schwertfeger KL, Benyumov AO, Manivel JC, Li S, Bielinsky AK, Yee D, Bitterman PB, Polunovsky VA.

Cancer Res. 2015 Feb 15;75(4):687-97. doi: 10.1158/0008-5472.CAN-14-2571. Epub 2014 Dec 18.


A novel Bcr-Abl-mTOR-eIF4A axis regulates IRES-mediated translation of LEF-1.

Tsai BP, Jimenez J, Lim S, Fitzgerald KD, Zhang M, Chuah CT, Axelrod H, Wilson L, Ong ST, Semler BL, Waterman ML.

Open Biol. 2014 Nov;4(11):140180. doi: 10.1098/rsob.140180.


Transcriptome-wide characterization of the eIF4A signature highlights plasticity in translation regulation.

Rubio CA, Weisburd B, Holderfield M, Arias C, Fang E, DeRisi JL, Fanidi A.

Genome Biol. 2014;15(10):476.


Celastrol induces unfolded protein response-dependent cell death in head and neck cancer.

Fribley AM, Miller JR, Brownell AL, Garshott DM, Zeng Q, Reist TE, Narula N, Cai P, Xi Y, Callaghan MU, Kodali V, Kaufman RJ.

Exp Cell Res. 2015 Jan 15;330(2):412-22. doi: 10.1016/j.yexcr.2014.08.014. Epub 2014 Aug 17.


Targeting of the MNK-eIF4E axis in blast crisis chronic myeloid leukemia inhibits leukemia stem cell function.

Lim S, Saw TY, Zhang M, Janes MR, Nacro K, Hill J, Lim AQ, Chang CT, Fruman DA, Rizzieri DA, Tan SY, Fan H, Chuah CT, Ong ST.

Proc Natl Acad Sci U S A. 2013 Jun 18;110(25):E2298-307. doi: 10.1073/pnas.1301838110. Epub 2013 Jun 4.


Distinct translational control in CD4+ T cell subsets.

Bjur E, Larsson O, Yurchenko E, Zheng L, Gandin V, Topisirovic I, Li S, Wagner CR, Sonenberg N, Piccirillo CA.

PLoS Genet. 2013 May;9(5):e1003494. doi: 10.1371/journal.pgen.1003494. Epub 2013 May 2.


Toward a genome-wide landscape of translational control.

Larsson O, Tian B, Sonenberg N.

Cold Spring Harb Perspect Biol. 2013 Jan 1;5(1):a012302. doi: 10.1101/cshperspect.a012302. Review.


Aberrations in translational regulation are associated with poor prognosis in hormone receptor-positive breast cancer.

Meric-Bernstam F, Chen H, Akcakanat A, Do KA, Lluch A, Hennessy BT, Hortobagyi GN, Mills GB, Gonzalez-Angulo A.

Breast Cancer Res. 2012 Oct 26;14(5):R138. doi: 10.1186/bcr3343.


Cap-dependent mRNA translation and the ubiquitin-proteasome system cooperate to promote ERBB2-dependent esophageal cancer phenotype.

Issaenko OA, Bitterman PB, Polunovsky VA, Dahlberg PS.

Cancer Gene Ther. 2012 Sep;19(9):609-18. doi: 10.1038/cgt.2012.39. Epub 2012 Jul 6.


The role of translation initiation regulation in haematopoiesis.

Grech G, von Lindern M.

Comp Funct Genomics. 2012;2012:576540. doi: 10.1155/2012/576540. Epub 2012 May 9.


Targeting synthetic lethal interactions between Myc and the eIF4F complex impedes tumorigenesis.

Lin CJ, Nasr Z, Premsrirut PK, Porco JA Jr, Hippo Y, Lowe SW, Pelletier J.

Cell Rep. 2012 Apr 19;1(4):325-33.


Attacking a nexus of the oncogenic circuitry by reversing aberrant eIF4F-mediated translation.

Bitterman PB, Polunovsky VA.

Mol Cancer Ther. 2012 May;11(5):1051-61. doi: 10.1158/1535-7163.MCT-11-0530. Review.


La enhances IRES-mediated translation of laminin B1 during malignant epithelial to mesenchymal transition.

Petz M, Them N, Huber H, Beug H, Mikulits W.

Nucleic Acids Res. 2012 Jan;40(1):290-302. doi: 10.1093/nar/gkr717. Epub 2011 Sep 6.

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