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Results: 1 to 20 of 34

1.

The HSP70 modulator MAL3-101 inhibits Merkel cell carcinoma.

Adam C, Baeurle A, Brodsky JL, Wipf P, Schrama D, Becker JC, Houben R.

PLoS One. 2014 Apr 2;9(4):e92041. doi: 10.1371/journal.pone.0092041. eCollection 2014.

PMID:
24694787
[PubMed - in process]
Free PMC Article
2.

Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2.

Patel PD, Yan P, Seidler PM, Patel HJ, Sun W, Yang C, Que NS, Taldone T, Finotti P, Stephani RA, Gewirth DT, Chiosis G.

Nat Chem Biol. 2013 Nov;9(11):677-84. doi: 10.1038/nchembio.1335. Epub 2013 Sep 1.

PMID:
23995768
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Experimental and structural testing module to analyze paralogue-specificity and affinity in the Hsp90 inhibitors series.

Taldone T, Patel PD, Patel M, Patel HJ, Evans CE, Rodina A, Ochiana S, Shah SK, Uddin M, Gewirth D, Chiosis G.

J Med Chem. 2013 Sep 12;56(17):6803-18. doi: 10.1021/jm400619b. Epub 2013 Aug 21.

PMID:
23965125
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Contributions of academic laboratories to the discovery and development of chemical biology tools.

Huryn DM, Resnick LO, Wipf P.

J Med Chem. 2013 Sep 26;56(18):7161-76. doi: 10.1021/jm400132d. Epub 2013 May 31. Review.

PMID:
23672690
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

The HSP70 family and cancer.

Murphy ME.

Carcinogenesis. 2013 Jun;34(6):1181-8. doi: 10.1093/carcin/bgt111. Epub 2013 Apr 4. Review.

PMID:
23563090
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Control of tumor bioenergetics and survival stress signaling by mitochondrial HSP90s.

Chae YC, Caino MC, Lisanti S, Ghosh JC, Dohi T, Danial NN, Villanueva J, Ferrero S, Vaira V, Santambrogio L, Bosari S, Languino LR, Herlyn M, Altieri DC.

Cancer Cell. 2012 Sep 11;22(3):331-44. doi: 10.1016/j.ccr.2012.07.015.

PMID:
22975376
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Allostery in the Hsp70 chaperone proteins.

Zuiderweg ER, Bertelsen EB, Rousaki A, Mayer MP, Gestwicki JE, Ahmad A.

Top Curr Chem. 2013;328:99-153. doi: 10.1007/128_2012_323. Review.

PMID:
22576356
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Advances in the discovery and development of heat-shock protein 90 inhibitors for cancer treatment.

Patel HJ, Modi S, Chiosis G, Taldone T.

Expert Opin Drug Discov. 2011 May;6(5):559-587.

PMID:
22400044
[PubMed]
Free PMC Article
9.

Antimyeloma Effects of the Heat Shock Protein 70 Molecular Chaperone Inhibitor MAL3-101.

Braunstein MJ, Scott SS, Scott CM, Behrman S, Walter P, Wipf P, Coplan JD, Chrico W, Joseph D, Brodsky JL, Batuman O.

J Oncol. 2011;2011:232037. doi: 10.1155/2011/232037. Epub 2011 Sep 29.

PMID:
21977030
[PubMed]
Free PMC Article
10.

Identifying inhibitors of epithelial-mesenchymal transition by connectivity map-based systems approach.

Reka AK, Kuick R, Kurapati H, Standiford TJ, Omenn GS, Keshamouni VG.

J Thorac Oncol. 2011 Nov;6(11):1784-92. doi: 10.1097/JTO.0b013e31822adfb0.

PMID:
21964532
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Quality control and fate determination of Hsp90 client proteins.

Theodoraki MA, Caplan AJ.

Biochim Biophys Acta. 2012 Mar;1823(3):683-8. doi: 10.1016/j.bbamcr.2011.08.006. Epub 2011 Aug 16. Review.

PMID:
21871502
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Emergence of potent inhibitors of metastasis in lung cancer via syntheses based on migrastatin.

Lecomte N, Njardarson JT, Nagorny P, Yang G, Downey R, Ouerfelli O, Moore MA, Danishefsky SJ.

Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15074-8. doi: 10.1073/pnas.1015247108. Epub 2011 Aug 1.

PMID:
21808037
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Chemical methodology as a source of small-molecule checkpoint inhibitors and heat shock protein 70 (Hsp70) modulators.

Huryn DM, Brodsky JL, Brummond KM, Chambers PG, Eyer B, Ireland AW, Kawasumi M, Laporte MG, Lloyd K, Manteau B, Nghiem P, Quade B, Seguin SP, Wipf P.

Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):6757-62. doi: 10.1073/pnas.1015251108. Epub 2011 Apr 18.

PMID:
21502524
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Design of a flexible cell-based assay for the evaluation of heat shock protein 70 expression modulators.

Ahn JH, Luo W, Kim J, Rodina A, Clement CC, Aguirre J, Sun W, Kang Y, Maharaj R, Moulick K, Zatorska D, Kokoszka M, Brodsky JL, Chiosis G.

Assay Drug Dev Technol. 2011 Jun;9(3):236-46. doi: 10.1089/adt.2010.0327. Epub 2010 Dec 6.

PMID:
21133677
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Heat shock protein 90 inhibition depletes LATS1 and LATS2, two regulators of the mammalian hippo tumor suppressor pathway.

Huntoon CJ, Nye MD, Geng L, Peterson KL, Flatten KS, Haluska P, Kaufmann SH, Karnitz LM.

Cancer Res. 2010 Nov 1;70(21):8642-50. doi: 10.1158/0008-5472.CAN-10-1345. Epub 2010 Sep 14.

PMID:
20841485
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Assay strategies for the discovery and validation of therapeutics targeting Brugia pahangi Hsp90.

Taldone T, Gillan V, Sun W, Rodina A, Patel P, Maitland K, O'Neill K, Chiosis G, Devaney E.

PLoS Negl Trop Dis. 2010 Jun 15;4(6):e714. doi: 10.1371/journal.pntd.0000714.

PMID:
20559560
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Induction of premature senescence by hsp90 inhibition in small cell lung cancer.

Restall IJ, Lorimer IA.

PLoS One. 2010 Jun 11;5(6):e11076. doi: 10.1371/journal.pone.0011076.

PMID:
20552022
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Binding of a small molecule at a protein-protein interface regulates the chaperone activity of hsp70-hsp40.

Wisén S, Bertelsen EB, Thompson AD, Patury S, Ung P, Chang L, Evans CG, Walter GM, Wipf P, Carlson HA, Brodsky JL, Zuiderweg ER, Gestwicki JE.

ACS Chem Biol. 2010 Jun 18;5(6):611-22. doi: 10.1021/cb1000422.

PMID:
20481474
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Heat shock protein 70 (hsp70) as an emerging drug target.

Evans CG, Chang L, Gestwicki JE.

J Med Chem. 2010 Jun 24;53(12):4585-602. doi: 10.1021/jm100054f. Review. No abstract available.

PMID:
20334364
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Brain-permeable small-molecule inhibitors of Hsp90 prevent alpha-synuclein oligomer formation and rescue alpha-synuclein-induced toxicity.

Putcha P, Danzer KM, Kranich LR, Scott A, Silinski M, Mabbett S, Hicks CD, Veal JM, Steed PM, Hyman BT, McLean PJ.

J Pharmacol Exp Ther. 2010 Mar;332(3):849-57. doi: 10.1124/jpet.109.158436. Epub 2009 Nov 24.

PMID:
19934398
[PubMed - indexed for MEDLINE]
Free PMC Article
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