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Cited In for PubMed (Select 17404115)


Combinations of Ashwagandha leaf extracts protect brain-derived cells against oxidative stress and induce differentiation.

Shah N, Singh R, Sarangi U, Saxena N, Chaudhary A, Kaur G, Kaul SC, Wadhwa R.

PLoS One. 2015 Mar 19;10(3):e0120554. doi: 10.1371/journal.pone.0120554. eCollection 2015.


Growth arrest by the antitumor steroidal lactone withaferin A in human breast cancer cells is associated with down-regulation and covalent binding at cysteine 303 of β-tubulin.

Antony ML, Lee J, Hahm ER, Kim SH, Marcus AI, Kumari V, Ji X, Yang Z, Vowell CL, Wipf P, Uechi GT, Yates NA, Romero G, Sarkar SN, Singh SV.

J Biol Chem. 2014 Jan 17;289(3):1852-65. doi: 10.1074/jbc.M113.496844. Epub 2013 Dec 2.


Withaferin A inhibits experimental epithelial-mesenchymal transition in MCF-10A cells and suppresses vimentin protein level in vivo in breast tumors.

Lee J, Hahm ER, Marcus AI, Singh SV.

Mol Carcinog. 2015 Jun;54(6):417-29. doi: 10.1002/mc.22110. Epub 2013 Nov 30.


Water extract of Ashwagandha leaves has anticancer activity: identification of an active component and its mechanism of action.

Wadhwa R, Singh R, Gao R, Shah N, Widodo N, Nakamoto T, Ishida Y, Terao K, Kaul SC.

PLoS One. 2013 Oct 10;8(10):e77189. doi: 10.1371/journal.pone.0077189. eCollection 2013. Erratum in: PLoS One. 2013;8(11). doi:10.1371/annotation/b7059f27-5970-4734-8601-9913adcce984.


Molecular interactions of Bcl-2 and Bcl-xL with mortalin: identification and functional characterization.

Saxena N, Katiyar SP, Liu Y, Grover A, Gao R, Sundar D, Kaul SC, Wadhwa R.

Biosci Rep. 2013 Oct 16;33(5). pii: e00073. doi: 10.1042/BSR20130034.


Molecular targets and mechanisms of cancer prevention and treatment by withaferin a, a naturally occurring steroidal lactone.

Vyas AR, Singh SV.

AAPS J. 2014 Jan;16(1):1-10. doi: 10.1208/s12248-013-9531-1. Epub 2013 Sep 18. Review.


Role of mitogen-activated protein kinases and Mcl-1 in apoptosis induction by withaferin A in human breast cancer cells.

Hahm ER, Lee J, Singh SV.

Mol Carcinog. 2014 Nov;53(11):907-16. doi: 10.1002/mc.22050. Epub 2013 Sep 9.


Metabolic alterations in mammary cancer prevention by withaferin A in a clinically relevant mouse model.

Hahm ER, Lee J, Kim SH, Sehrawat A, Arlotti JA, Shiva SS, Bhargava R, Singh SV.

J Natl Cancer Inst. 2013 Aug 7;105(15):1111-22. doi: 10.1093/jnci/djt153. Epub 2013 Jul 2.


Golden berry-derived 4β-hydroxywithanolide E for selectively killing oral cancer cells by generating ROS, DNA damage, and apoptotic pathways.

Chiu CC, Haung JW, Chang FR, Huang KJ, Huang HM, Huang HW, Chou CK, Wu YC, Chang HW.

PLoS One. 2013 May 21;8(5):e64739. doi: 10.1371/journal.pone.0064739. Print 2013.


Mood disorders and complementary and alternative medicine: a literature review.

Qureshi NA, Al-Bedah AM.

Neuropsychiatr Dis Treat. 2013;9:639-58. doi: 10.2147/NDT.S43419. Epub 2013 May 14.


Mitotic Stress and Chromosomal Instability in Cancer: The Case for TPX2.

Pérez de Castro I, Malumbres M.

Genes Cancer. 2012 Nov;3(11-12):721-30. doi: 10.1177/1947601912473306.


Autophagy fails to alter withaferin A-mediated lethality in human breast cancer cells.

Hahm ER, Singh SV.

Curr Cancer Drug Targets. 2013 Jul;13(6):640-50.


Differential activities of the two closely related withanolides, Withaferin A and Withanone: bioinformatics and experimental evidences.

Vaishnavi K, Saxena N, Shah N, Singh R, Manjunath K, Uthayakumar M, Kanaujia SP, Kaul SC, Sekar K, Wadhwa R.

PLoS One. 2012;7(9):e44419. doi: 10.1371/journal.pone.0044419. Epub 2012 Sep 4.


Withaferin A causes activation of Notch2 and Notch4 in human breast cancer cells.

Lee J, Sehrawat A, Singh SV.

Breast Cancer Res Treat. 2012 Nov;136(1):45-56. doi: 10.1007/s10549-012-2239-6. Epub 2012 Sep 11.


Withaferin A-induced apoptosis in human breast cancer cells is associated with suppression of inhibitor of apoptosis family protein expression.

Hahm ER, Singh SV.

Cancer Lett. 2013 Jun 28;334(1):101-8. doi: 10.1016/j.canlet.2012.08.026. Epub 2012 Aug 27.


Ashwagandha derived withanone targets TPX2-Aurora A complex: computational and experimental evidence to its anticancer activity.

Grover A, Singh R, Shandilya A, Priyandoko D, Agrawal V, Bisaria VS, Wadhwa R, Kaul SC, Sundar D.

PLoS One. 2012;7(1):e30890. doi: 10.1371/journal.pone.0030890. Epub 2012 Jan 27.


Protective role of Ashwagandha leaf extract and its component withanone on scopolamine-induced changes in the brain and brain-derived cells.

Konar A, Shah N, Singh R, Saxena N, Kaul SC, Wadhwa R, Thakur MK.

PLoS One. 2011;6(11):e27265. doi: 10.1371/journal.pone.0027265. Epub 2011 Nov 11.


Ashwagandha leaf derived withanone protects normal human cells against the toxicity of methoxyacetic acid, a major industrial metabolite.

Priyandoko D, Ishii T, Kaul SC, Wadhwa R.

PLoS One. 2011 May 4;6(5):e19552. doi: 10.1371/journal.pone.0019552.


Selective killing of cancer cells by Ashwagandha leaf extract and its component Withanone involves ROS signaling.

Widodo N, Priyandoko D, Shah N, Wadhwa R, Kaul SC.

PLoS One. 2010 Oct 21;5(10):e13536. doi: 10.1371/journal.pone.0013536.


Water extract of ashwagandha leaves limits proliferation and migration, and induces differentiation in glioma cells.

Kataria H, Shah N, Kaul SC, Wadhwa R, Kaur G.

Evid Based Complement Alternat Med. 2011;2011:267614. doi: 10.1093/ecam/nep188. Epub 2011 Feb 14.

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