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Results: 1 to 20 of 60

1.

Dyslipidemia in rat fed with high-fat diet is not associated with PCSK9-LDL-receptor pathway but ageing.

Jia YJ, Liu J, Guo YL, Xu RX, Sun J, Li JJ.

J Geriatr Cardiol. 2013 Dec;10(4):361-8. doi: 10.3969/j.issn.1671-5411.2013.04.007.

PMID:
24454330
[PubMed]
Free PMC Article
2.

Re-sequencing of the APOAI promoter region and the genetic association of the -75G > A polymorphism with increased cholesterol and low density lipoprotein levels among a sample of the Kuwaiti population.

Al-Bustan SA, Al-Serri AE, Annice BG, Alnaqeeb MA, Ebrahim GA.

BMC Med Genet. 2013 Sep 12;14:90. doi: 10.1186/1471-2350-14-90.

PMID:
24028463
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

PCSK9 - A New and Potent Approach to Lowering Cholesterol.

Whayne TF Jr.

Oman Med J. 2013 May;28(3):155-8. doi: 10.5001/omj.2013.45. No abstract available.

PMID:
23772278
[PubMed]
Free PMC Article
4.

More on cholesterol trafficking in the body!

Al-Musalhi K, Nair DR.

Oman Med J. 2013 Mar;28(2):84-5. doi: 10.5001/omj.2013.23. No abstract available.

PMID:
23599873
[PubMed]
Free PMC Article
5.

Elevated PCSK9 levels in untreated patients with heterozygous or homozygous familial hypercholesterolemia and the response to high-dose statin therapy.

Raal F, Panz V, Immelman A, Pilcher G.

J Am Heart Assoc. 2013 Apr 24;2(2):e000028. doi: 10.1161/JAHA.112.000028.

PMID:
23537802
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Targeting LDL Cholesterol With LNA.

Krieg AM.

Mol Ther Nucleic Acids. 2012 Jan 31;1:e6. doi: 10.1038/mtna.2011.8. No abstract available.

PMID:
23344623
[PubMed]
Free PMC Article
7.

Plasma PCSK9 concentrations during an oral fat load and after short term high-fat, high-fat high-protein and high-fructose diets.

Cariou B, Langhi C, Le Bras M, Bortolotti M, Lê KA, Theytaz F, Le May C, Guyomarc'h-Delasalle B, Zaïr Y, Kreis R, Boesch C, Krempf M, Tappy L, Costet P.

Nutr Metab (Lond). 2013 Jan 8;10(1):4. doi: 10.1186/1743-7075-10-4.

PMID:
23298392
[PubMed]
Free PMC Article
8.

The oxysterol 24(s),25-epoxycholesterol attenuates human smooth muscle-derived foam cell formation via reduced low-density lipoprotein uptake and enhanced cholesterol efflux.

Beyea MM, Reaume S, Sawyez CG, Edwards JY, O'Neil C, Hegele RA, Pickering JG, Huff MW.

J Am Heart Assoc. 2012 Jun;1(3):e000810. doi: 10.1161/JAHA.112.000810. Epub 2012 Jun 22.

PMID:
23130136
[PubMed]
Free PMC Article
9.

A method for integrative structure determination of protein-protein complexes.

Schneidman-Duhovny D, Rossi A, Avila-Sakar A, Kim SJ, Velázquez-Muriel J, Strop P, Liang H, Krukenberg KA, Liao M, Kim HM, Sobhanifar S, Dötsch V, Rajpal A, Pons J, Agard DA, Cheng Y, Sali A.

Bioinformatics. 2012 Dec 15;28(24):3282-9. doi: 10.1093/bioinformatics/bts628. Epub 2012 Oct 23.

PMID:
23093611
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Low prevalence of mutations in known loci for autosomal dominant hypercholesterolemia in a multiethnic patient cohort.

Ahmad Z, Adams-Huet B, Chen C, Garg A.

Circ Cardiovasc Genet. 2012 Dec;5(6):666-75. doi: 10.1161/CIRCGENETICS.112.963587. Epub 2012 Oct 11.

PMID:
23064986
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Silencing of lipid metabolism genes through IRE1α-mediated mRNA decay lowers plasma lipids in mice.

So JS, Hur KY, Tarrio M, Ruda V, Frank-Kamenetsky M, Fitzgerald K, Koteliansky V, Lichtman AH, Iwawaki T, Glimcher LH, Lee AH.

Cell Metab. 2012 Oct 3;16(4):487-99. doi: 10.1016/j.cmet.2012.09.004.

PMID:
23040070
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Hypomorphic sialidase expression decreases serum cholesterol by downregulation of VLDL production in mice.

Yang A, Gyulay G, Mitchell M, White E, Trigatti BL, Igdoura SA.

J Lipid Res. 2012 Dec;53(12):2573-85. doi: 10.1194/jlr.M027300. Epub 2012 Sep 14.

PMID:
22984145
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Familial hypobetalipoproteinemia-induced nonalcoholic steatohepatitis.

Lam MC, Singham J, Hegele RA, Riazy M, Hiob MA, Francis G, Steinbrecher UP.

Case Rep Gastroenterol. 2012 May;6(2):429-37. doi: 10.1159/000339761. Epub 2012 Jul 3.

PMID:
22855658
[PubMed]
Free PMC Article
14.

Molecular characterization of proprotein convertase subtilisin/kexin type 9-mediated degradation of the LDLR.

Wang Y, Huang Y, Hobbs HH, Cohen JC.

J Lipid Res. 2012 Sep;53(9):1932-43. doi: 10.1194/jlr.M028563. Epub 2012 Jul 4.

PMID:
22764087
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Immunization against proprotein convertase subtilisin-like/kexin type 9 lowers plasma LDL-cholesterol levels in mice.

Fattori E, Cappelletti M, Lo Surdo P, Calzetta A, Bendtsen C, Ni YG, Pandit S, Sitlani A, Mesiti G, Carfí A, Monaci P.

J Lipid Res. 2012 Aug;53(8):1654-61. doi: 10.1194/jlr.M028340. Epub 2012 May 19.

PMID:
22611251
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Increased hepatic synthesis and dysregulation of cholesterol metabolism is associated with the severity of nonalcoholic fatty liver disease.

Min HK, Kapoor A, Fuchs M, Mirshahi F, Zhou H, Maher J, Kellum J, Warnick R, Contos MJ, Sanyal AJ.

Cell Metab. 2012 May 2;15(5):665-74. doi: 10.1016/j.cmet.2012.04.004.

PMID:
22560219
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Blockade of cholesterol absorption by ezetimibe reveals a complex homeostatic network in enterocytes.

Engelking LJ, McFarlane MR, Li CK, Liang G.

J Lipid Res. 2012 Jul;53(7):1359-68. doi: 10.1194/jlr.M027599. Epub 2012 Apr 22.

PMID:
22523394
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Regulation of epithelial sodium channel trafficking by proprotein convertase subtilisin/kexin type 9 (PCSK9).

Sharotri V, Collier DM, Olson DR, Zhou R, Snyder PM.

J Biol Chem. 2012 Jun 1;287(23):19266-74. doi: 10.1074/jbc.M112.363382. Epub 2012 Apr 9.

PMID:
22493497
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Fabs enable single particle cryoEM studies of small proteins.

Wu S, Avila-Sakar A, Kim J, Booth DS, Greenberg CH, Rossi A, Liao M, Li X, Alian A, Griner SL, Juge N, Yu Y, Mergel CM, Chaparro-Riggers J, Strop P, Tampé R, Edwards RH, Stroud RM, Craik CS, Cheng Y.

Structure. 2012 Apr 4;20(4):582-92. doi: 10.1016/j.str.2012.02.017. Epub 2012 Apr 3.

PMID:
22483106
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

An anti-PCSK9 antibody reduces LDL-cholesterol on top of a statin and suppresses hepatocyte SREBP-regulated genes.

Zhang L, McCabe T, Condra JH, Ni YG, Peterson LB, Wang W, Strack AM, Wang F, Pandit S, Hammond H, Wood D, Lewis D, Rosa R, Mendoza V, Cumiskey AM, Johns DG, Hansen BC, Shen X, Geoghagen N, Jensen K, Zhu L, Wietecha K, Wisniewski D, Huang L, Zhao JZ, Ernst R, Hampton R, Haytko P, Ansbro F, Chilewski S, Chin J, Mitnaul LJ, Pellacani A, Sparrow CP, An Z, Strohl W, Hubbard B, Plump AS, Blom D, Sitlani A.

Int J Biol Sci. 2012;8(3):310-27. doi: 10.7150/ijbs.3524. Epub 2012 Feb 9.

PMID:
22355267
[PubMed - indexed for MEDLINE]
Free PMC Article

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