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Wnt Protein Signaling Reduces Nuclear Acetyl-CoA Levels to Suppress Gene Expression during Osteoblast Differentiation.

Karner CM, Esen E, Chen J, Hsu FF, Turk J, Long F.

J Biol Chem. 2016 Jun 17;291(25):13028-39. doi: 10.1074/jbc.M115.708578. Epub 2016 Apr 20.


Sphingosine 1-Phosphate-Induced ICAM-1 Expression via NADPH Oxidase/ROS-Dependent NF-κB Cascade on Human Pulmonary Alveolar Epithelial Cells.

Lin CC, Yang CC, Cho RL, Wang CY, Hsiao LD, Yang CM.

Front Pharmacol. 2016 Mar 31;7:80. doi: 10.3389/fphar.2016.00080. eCollection 2016.


A monoclonal antibody against the Wnt signaling inhibitor dickkopf-1 inhibits osteosarcoma metastasis in a preclinical model.

Goldstein SD, Trucco M, Bautista Guzman W, Hayashi M, Loeb DM.

Oncotarget. 2016 Apr 19;7(16):21114-23. doi: 10.18632/oncotarget.8522.


Genetic insights into the mechanisms of Fgf signaling.

Brewer JR, Mazot P, Soriano P.

Genes Dev. 2016 Apr 1;30(7):751-71. doi: 10.1101/gad.277137.115. Review.


Rictor is required for optimal bone accrual in response to anti-sclerostin therapy in the mouse.

Sun W, Shi Y, Lee WC, Lee SY, Long F.

Bone. 2016 Apr;85:1-8. doi: 10.1016/j.bone.2016.01.013. Epub 2016 Jan 15.


Feedback regulation of G protein-coupled receptor signaling by GRKs and arrestins.

Black JB, Premont RT, Daaka Y.

Semin Cell Dev Biol. 2016 Feb;50:95-104. doi: 10.1016/j.semcdb.2015.12.015. Epub 2016 Jan 7. Review.


Wnt signaling in bone and muscle.

Rudnicki MA, Williams BO.

Bone. 2015 Nov;80:60-6. doi: 10.1016/j.bone.2015.02.009. Review.


Protein kinase C delta null mice exhibit structural alterations in articular surface, intra-articular and subchondral compartments.

Yang X, Teguh D, Wu JP, He B, Kirk TB, Qin S, Li S, Chen H, Xue W, Ng B, Chim SM, Tickner J, Xu J.

Arthritis Res Ther. 2015 Aug 17;17:210. doi: 10.1186/s13075-015-0720-4.


Endogenous Glucocorticoids and Bone.

Zhou H, Cooper MS, Seibel MJ.

Bone Res. 2013 Jun 28;1(2):107-19. doi: 10.4248/BR201302001. eCollection 2013 Jun. Review.


A Comprehensive Overview of Skeletal Phenotypes Associated with Alterations in Wnt/β-catenin Signaling in Humans and Mice.

Maupin KA, Droscha CJ, Williams BO.

Bone Res. 2013 Mar 29;1(1):27-71. doi: 10.4248/BR201301004. eCollection 2013 Mar. Review.


Vascular smooth muscle LRP6 limits arteriosclerotic calcification in diabetic LDLR-/- mice by restraining noncanonical Wnt signals.

Cheng SL, Ramachandran B, Behrmann A, Shao JS, Mead M, Smith C, Krchma K, Bello Arredondo Y, Kovacs A, Kapoor K, Brill LM, Perera R, Williams BO, Towler DA.

Circ Res. 2015 Jul 3;117(2):142-56. doi: 10.1161/CIRCRESAHA.117.306712. Epub 2015 Jun 1.


A new WNT on the bone: WNT16, cortical bone thickness, porosity and fractures.

Gori F, Lerner U, Ohlsson C, Baron R.

Bonekey Rep. 2015 May 13;4:669. doi: 10.1038/bonekey.2015.36. eCollection 2015. Review.


ANGPTL7 regulates the expansion and repopulation of human hematopoietic stem and progenitor cells.

Xiao Y, Jiang Z, Li Y, Ye W, Jia B, Zhang M, Xu Y, Wu D, Lai L, Chen Y, Chang Y, Huang X, Liu H, Qing G, Liu P, Li Y, Xu B, Zhong M, Yao Y, Pei D, Li P.

Haematologica. 2015 May;100(5):585-94. doi: 10.3324/haematol.2014.118612. Epub 2015 Jan 30.


Increased glutamine catabolism mediates bone anabolism in response to WNT signaling.

Karner CM, Esen E, Okunade AL, Patterson BW, Long F.

J Clin Invest. 2015 Feb;125(2):551-62. doi: 10.1172/JCI78470. Epub 2014 Dec 22.


Inhibition of phosphodiesterase 5 reduces bone mass by suppression of canonical Wnt signaling.

Gong Y, Xu CY, Wang JR, Hu XH, Hong D, Ji X, Shi W, Chen HX, Wang HB, Wu XM.

Cell Death Dis. 2014 Nov 27;5:e1544. doi: 10.1038/cddis.2014.510.


Wnts produced by Osterix-expressing osteolineage cells regulate their proliferation and differentiation.

Tan SH, Senarath-Yapa K, Chung MT, Longaker MT, Wu JY, Nusse R.

Proc Natl Acad Sci U S A. 2014 Dec 9;111(49):E5262-71. doi: 10.1073/pnas.1420463111. Epub 2014 Nov 24.


The osteogenic or adipogenic lineage commitment of human mesenchymal stem cells is determined by protein kinase C delta.

Lee S, Cho HY, Bui HT, Kang D.

BMC Cell Biol. 2014 Nov 25;15:42. doi: 10.1186/s12860-014-0042-4.


WNT signaling in bone development and homeostasis.

Zhong Z, Ethen NJ, Williams BO.

Wiley Interdiscip Rev Dev Biol. 2014 Nov-Dec;3(6):489-500. doi: 10.1002/wdev.159. Epub 2014 Sep 30. Review.


mTORC2 signaling promotes skeletal growth and bone formation in mice.

Chen J, Holguin N, Shi Y, Silva MJ, Long F.

J Bone Miner Res. 2015 Feb;30(2):369-78. doi: 10.1002/jbmr.2348.


Targeted reduction of vascular Msx1 and Msx2 mitigates arteriosclerotic calcification and aortic stiffness in LDLR-deficient mice fed diabetogenic diets.

Cheng SL, Behrmann A, Shao JS, Ramachandran B, Krchma K, Bello Arredondo Y, Kovacs A, Mead M, Maxson R, Towler DA.

Diabetes. 2014 Dec;63(12):4326-37. doi: 10.2337/db14-0326. Epub 2014 Jul 23.

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