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Items: 1 to 20 of 179


Amyloid Proteins and Their Role in Multiple Sclerosis. Considerations in the Use of Amyloid-PET Imaging.

Matías-Guiu JA, Oreja-Guevara C, Cabrera-Martín MN, Moreno-Ramos T, Carreras JL, Matías-Guiu J.

Front Neurol. 2016 Mar 31;7:53. doi: 10.3389/fneur.2016.00053. eCollection 2016. Review.


Pharmacological BACE1 and BACE2 inhibition induces hair depigmentation by inhibiting PMEL17 processing in mice.

Shimshek DR, Jacobson LH, Kolly C, Zamurovic N, Balavenkatraman KK, Morawiec L, Kreutzer R, Schelle J, Jucker M, Bertschi B, Theil D, Heier A, Bigot K, Beltz K, Machauer R, Brzak I, Perrot L, Neumann U.

Sci Rep. 2016 Feb 25;6:21917. doi: 10.1038/srep21917.


The Ubiquitin-Proteasome System: Potential Therapeutic Targets for Alzheimer's Disease and Spinal Cord Injury.

Gong B, Radulovic M, Figueiredo-Pereira ME, Cardozo C.

Front Mol Neurosci. 2016 Jan 26;9:4. doi: 10.3389/fnmol.2016.00004. eCollection 2016. Review.


Neuregulin1 displayed on motor axons regulates terminal Schwann cell-mediated synapse elimination at developing neuromuscular junctions.

Lee YI, Li Y, Mikesh M, Smith I, Nave KA, Schwab MH, Thompson WJ.

Proc Natl Acad Sci U S A. 2016 Jan 26;113(4):E479-87. doi: 10.1073/pnas.1519156113. Epub 2016 Jan 11.


Proteolytic Processing of Neuregulin 1 Type III by Three Intramembrane-cleaving Proteases.

Fleck D, Voss M, Brankatschk B, Giudici C, Hampel H, Schwenk B, Edbauer D, Fukumori A, Steiner H, Kremmer E, Haug-Kröper M, Rossner MJ, Fluhrer R, Willem M, Haass C.

J Biol Chem. 2016 Jan 1;291(1):318-33. doi: 10.1074/jbc.M115.697995. Epub 2015 Nov 16.


Neurological dysfunctions associated with altered BACE1-dependent Neuregulin-1 signaling.

Hu X, Fan Q, Hou H, Yan R.

J Neurochem. 2016 Jan;136(2):234-49. doi: 10.1111/jnc.13395. Epub 2015 Nov 13. Review.


Fluid Biomarkers in Clinical Trials of Alzheimer's Disease Therapeutics.

Ritter A, Cummings J.

Front Neurol. 2015 Aug 31;6:186. doi: 10.3389/fneur.2015.00186. eCollection 2015. Review.


The keystone of Alzheimer pathogenesis might be sought in Aβ physiology.

Puzzo D, Gulisano W, Arancio O, Palmeri A.

Neuroscience. 2015 Oct 29;307:26-36. doi: 10.1016/j.neuroscience.2015.08.039. Epub 2015 Aug 24. Review.


Antagonistic Effects of BACE1 and APH1B-γ-Secretase Control Axonal Guidance by Regulating Growth Cone Collapse.

Barão S, Gärtner A, Leyva-Díaz E, Demyanenko G, Munck S, Vanhoutvin T, Zhou L, Schachner M, López-Bendito G, Maness PF, De Strooper B.

Cell Rep. 2015 Sep 1;12(9):1367-76. doi: 10.1016/j.celrep.2015.07.059. Epub 2015 Aug 20.


Swedish mutant APP-based BACE1 binding site peptide reduces APP β-cleavage and cerebral Aβ levels in Alzheimer's mice.

Li S, Hou H, Mori T, Sawmiller D, Smith A, Tian J, Wang Y, Giunta B, Sanberg PR, Zhang S, Tan J.

Sci Rep. 2015 Jun 19;5:11322. doi: 10.1038/srep11322.


Neuregulin 1 expression and electrophysiological abnormalities in the Neuregulin 1 transmembrane domain heterozygous mutant mouse.

Long LE, Anderson P, Frank E, Shaw A, Liu S, Huang XF, Pinault D, Karl T, O'Brien TJ, Shannon Weickert C, Jones NC.

PLoS One. 2015 May 19;10(5):e0124114. doi: 10.1371/journal.pone.0124114. eCollection 2015.


The roles of neuregulin-1 in cardiac development, homeostasis, and disease.

Rupert CE, Coulombe KL.

Biomark Insights. 2015 Apr 8;10(Suppl 1):1-9. doi: 10.4137/BMI.S20061. eCollection 2015. Review.


New insights on Schwann cell development.

Monk KR, Feltri ML, Taveggia C.

Glia. 2015 Aug;63(8):1376-93. doi: 10.1002/glia.22852. Epub 2015 Apr 29. Review.


Physiological and behavioral effects of amphetamine in BACE1(-/-) mice.

Paredes RM, Piccart E, Navaira E, Cruz D, Javors MA, Koek W, Beckstead MJ, Walss-Bass C.

Genes Brain Behav. 2015 Jun;14(5):411-8. doi: 10.1111/gbb.12222. Epub 2015 May 21.


Disturbed calcium signaling in spinocerebellar ataxias and Alzheimer's disease.

Egorova P, Popugaeva E, Bezprozvanny I.

Semin Cell Dev Biol. 2015 Apr;40:127-33. doi: 10.1016/j.semcdb.2015.03.010. Epub 2015 Apr 4. Review.


Expression pattern of neuregulin-1 type III during the development of the peripheral nervous system.

Huang LL, Liu ZY, Huang JH, Luo ZJ.

Neural Regen Res. 2015 Jan;10(1):65-70. doi: 10.4103/1673-5374.150708.


Differential roles of Aβ processing in hypoxia-induced axonal damage.

Christianson MG, Lo DC.

Neurobiol Dis. 2015 May;77:94-105. doi: 10.1016/j.nbd.2015.02.027. Epub 2015 Mar 11.


Axonal and Schwann cell BACE1 is equally required for remyelination of peripheral nerves.

Hu X, Hu J, Dai L, Trapp B, Yan R.

J Neurosci. 2015 Mar 4;35(9):3806-14. doi: 10.1523/JNEUROSCI.5207-14.2015.


The resveratrol trimer miyabenol C inhibits β-secretase activity and β-amyloid generation.

Hu J, Lin T, Gao Y, Xu J, Jiang C, Wang G, Bu G, Xu H, Chen H, Zhang YW.

PLoS One. 2015 Jan 28;10(1):e0115973. doi: 10.1371/journal.pone.0115973. eCollection 2015.


BACE1 inhibitor drugs in clinical trials for Alzheimer's disease.

Vassar R.

Alzheimers Res Ther. 2014 Dec 24;6(9):89. doi: 10.1186/s13195-014-0089-7. eCollection 2014.

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