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Disruption of the AMPK-TBC1D1 nexus increases lipogenic gene expression and causes obesity in mice via promoting IGF1 secretion.

Chen L, Chen Q, Xie B, Quan C, Sheng Y, Zhu S, Rong P, Zhou S, Sakamoto K, MacKintosh C, Wang HY, Chen S.

Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):7219-24. doi: 10.1073/pnas.1600581113. Epub 2016 Jun 15.


A Copy Number Variant on Chromosome 20q13.3 Implicated in Thinness and Severe Obesity.

Hasstedt SJ, Xin Y, Mao R, Lewis T, Adams TD, Hunt SC.

J Obes. 2015;2015:623431. doi: 10.1155/2015/623431. Epub 2015 Dec 31.


Analysis of Genes Involved in Body Weight Regulation by Targeted Re-Sequencing.

Volckmar AL, Han CT, Pütter C, Haas S, Vogel CI, Knoll N, Struve C, Göbel M, Haas K, Herrfurth N, Jarick I, Grallert H, Schürmann A, Al-Hasani H, Hebebrand J, Sauer S, Hinney A.

PLoS One. 2016 Feb 1;11(2):e0147904. doi: 10.1371/journal.pone.0147904. eCollection 2016.


Rab GAPs AS160 and Tbc1d1 play nonredundant roles in the regulation of glucose and energy homeostasis in mice.

Hargett SR, Walker NN, Keller SR.

Am J Physiol Endocrinol Metab. 2016 Feb 15;310(4):E276-88. doi: 10.1152/ajpendo.00342.2015. Epub 2015 Dec 1.


Probabilistic models of genetic variation in structured populations applied to global human studies.

Hao W, Song M, Storey JD.

Bioinformatics. 2016 Mar 1;32(5):713-21. doi: 10.1093/bioinformatics/btv641. Epub 2015 Nov 6.


Identification of Four Mouse Diabetes Candidate Genes Altering β-Cell Proliferation.

Kluth O, Matzke D, Kamitz A, Jähnert M, Vogel H, Scherneck S, Schulze M, Staiger H, Machicao F, Häring HU, Joost HG, Schürmann A.

PLoS Genet. 2015 Sep 8;11(9):e1005506. doi: 10.1371/journal.pgen.1005506. eCollection 2015 Sep.


Confrontation of fibroblasts with cancer cells in vitro: gene network analysis of transcriptome changes and differential capacity to inhibit tumor growth.

Alexeyenko A, Alkasalias T, Pavlova T, Szekely L, Kashuba V, Rundqvist H, Wiklund P, Egevad L, Csermely P, Korcsmaros T, Guven H, Klein G.

J Exp Clin Cancer Res. 2015 Jun 18;34:62. doi: 10.1186/s13046-015-0178-x.


Deletion of the Rab GAP Tbc1d1 modifies glucose, lipid, and energy homeostasis in mice.

Hargett SR, Walker NN, Hussain SS, Hoehn KL, Keller SR.

Am J Physiol Endocrinol Metab. 2015 Aug 1;309(3):E233-45. doi: 10.1152/ajpendo.00007.2015. Epub 2015 May 26.


Obesity genetics in mouse and human: back and forth, and back again.

Yazdi FT, Clee SM, Meyre D.

PeerJ. 2015 Mar 24;3:e856. doi: 10.7717/peerj.856. eCollection 2015. Review.


Fine-scale genetic correlates to condition and migration in a wild cervid.

Northrup JM, Shafer AB, Anderson CR, Coltman DW, Wittemyer G.

Evol Appl. 2014 Sep;7(8):937-48. doi: 10.1111/eva.12189. Epub 2014 Aug 28.


Identification and Association of SNPs in TBC1D1 Gene with Growth Traits in Two Rabbit Breeds.

Yang ZJ, Fu L, Zhang GW, Yang Y, Chen SY, Wang J, Lai SJ.

Asian-Australas J Anim Sci. 2013 Nov;26(11):1529-35. doi: 10.5713/ajas.2013.13278.


The genetic basis of obesity-associated type 2 diabetes (diabesity) in polygenic mouse models.

Joost HG, Schürmann A.

Mamm Genome. 2014 Oct;25(9-10):401-12. doi: 10.1007/s00335-014-9514-2. Epub 2014 Apr 22. Review.


Dysregulated expression of lipid storage and membrane dynamics factors in Tia1 knockout mouse nervous tissue.

Heck MV, Azizov M, Stehning T, Walter M, Kedersha N, Auburger G.

Neurogenetics. 2014 May;15(2):135-44.


Mitochondrial dysfunction and decrease in body weight of a transgenic knock-in mouse model for TDP-43.

Stribl C, Samara A, Trümbach D, Peis R, Neumann M, Fuchs H, Gailus-Durner V, Hrabě de Angelis M, Rathkolb B, Wolf E, Beckers J, Horsch M, Neff F, Kremmer E, Koob S, Reichert AS, Hans W, Rozman J, Klingenspor M, Aichler M, Walch AK, Becker L, Klopstock T, Glasl L, Hölter SM, Wurst W, Floss T.

J Biol Chem. 2014 Apr 11;289(15):10769-84. doi: 10.1074/jbc.M113.515940. Epub 2014 Feb 10.


Genetic variation in the prostaglandin E2 pathway is associated with primary graft dysfunction.

Diamond JM, Akimova T, Kazi A, Shah RJ, Cantu E, Feng R, Levine MH, Kawut SM, Meyer NJ, Lee JC, Hancock WW, Aplenc R, Ware LB, Palmer SM, Bhorade S, Lama VN, Weinacker A, Orens J, Wille K, Crespo M, Lederer DJ, Arcasoy S, Demissie E, Christie JD; Lung Transplant Outcomes Group.

Am J Respir Crit Care Med. 2014 Mar 1;189(5):567-75. doi: 10.1164/rccm.201307-1283OC.


Genetic and epigenetic control of metabolic health.

Schwenk RW, Vogel H, Schürmann A.

Mol Metab. 2013 Sep 25;2(4):337-47. doi: 10.1016/j.molmet.2013.09.002. Review.


Human cardiovascular disease IBC chip-wide association with weight loss and weight regain in the look AHEAD trial.

McCaffery JM, Papandonatos GD, Huggins GS, Peter I, Erar B, Kahn SE, Knowler WC, Lipkin EW, Kitabchi AE, Wagenknecht LE, Wing RR; Genetic Subgroup of Look AHEAD; Look AHEAD Research Group.

Hum Hered. 2013;75(2-4):160-74. doi: 10.1159/000353181. Epub 2013 Sep 27.


TDP-43, an ALS linked protein, regulates fat deposition and glucose homeostasis.

Stallings NR, Puttaparthi K, Dowling KJ, Luther CM, Burns DK, Davis K, Elliott JL.

PLoS One. 2013 Aug 13;8(8):e71793. doi: 10.1371/journal.pone.0071793. eCollection 2013.


Metabolic syndrome and insulin resistance: underlying causes and modification by exercise training.

Roberts CK, Hevener AL, Barnard RJ.

Compr Physiol. 2013 Jan;3(1):1-58. doi: 10.1002/cphy.c110062. Review.


Structural and population-based evaluations of TBC1D1 p.Arg125Trp.

Richardson TG, Thomas EC, Sessions RB, Lawlor DA, Tavaré JM, Day IN.

PLoS One. 2013 May 7;8(5):e63897. doi: 10.1371/journal.pone.0063897. Print 2013.

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