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Regulators of Slc4 bicarbonate transporter activity.

Thornell IM, Bevensee MO.

Front Physiol. 2015 Jun 12;6:166. doi: 10.3389/fphys.2015.00166. eCollection 2015. Review.


Critical role of the SPAK protein kinase CCT domain in controlling blood pressure.

Zhang J, Siew K, Macartney T, O'Shaughnessy KM, Alessi DR.

Hum Mol Genet. 2015 Aug 15;24(16):4545-58. doi: 10.1093/hmg/ddv185. Epub 2015 May 20.


A unifying mechanism for WNK kinase regulation of sodium-chloride cotransporter.

Huang CL, Cheng CJ.

Pflugers Arch. 2015 Nov;467(11):2235-41. doi: 10.1007/s00424-015-1708-2. Epub 2015 Apr 24. Review.


Identification of the WNK-SPAK/OSR1 signaling pathway in rodent and human lenses.

Vorontsova I, Lam L, Delpire E, Lim J, Donaldson P.

Invest Ophthalmol Vis Sci. 2014 Dec 16;56(1):310-21. doi: 10.1167/iovs.14-15911.


Actions of the protein kinase WNK1 on endothelial cells are differentially mediated by its substrate kinases OSR1 and SPAK.

Dbouk HA, Weil LM, Perera GK, Dellinger MT, Pearson G, Brekken RA, Cobb MH.

Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):15999-6004. doi: 10.1073/pnas.1419057111. Epub 2014 Oct 31.


Zebrafish WNK lysine deficient protein kinase 1 (wnk1) affects angiogenesis associated with VEGF signaling.

Lai JG, Tsai SM, Tu HC, Chen WC, Kou FJ, Lu JW, Wang HD, Huang CL, Yuh CH.

PLoS One. 2014 Aug 29;9(8):e106129. doi: 10.1371/journal.pone.0106129. eCollection 2014.


Hypotonicity stimulates potassium flux through the WNK-SPAK/OSR1 kinase cascade and the Ncc69 sodium-potassium-2-chloride cotransporter in the Drosophila renal tubule.

Wu Y, Schellinger JN, Huang CL, Rodan AR.

J Biol Chem. 2014 Sep 19;289(38):26131-42. doi: 10.1074/jbc.M114.577767. Epub 2014 Aug 1.


Mechanisms of CFTR functional variants that impair regulated bicarbonate permeation and increase risk for pancreatitis but not for cystic fibrosis.

LaRusch J, Jung J, General IJ, Lewis MD, Park HW, Brand RE, Gelrud A, Anderson MA, Banks PA, Conwell D, Lawrence C, Romagnuolo J, Baillie J, Alkaade S, Cote G, Gardner TB, Amann ST, Slivka A, Sandhu B, Aloe A, Kienholz ML, Yadav D, Barmada MM, Bahar I, Lee MG, Whitcomb DC; North American Pancreatitis Study Group.

PLoS Genet. 2014 Jul 17;10(7):e1004376. doi: 10.1371/journal.pgen.1004376. eCollection 2014 Jul. Erratum in: PLoS Genet. 2014 Oct;10(10):e1004778.


Chloride sensing by WNK1 involves inhibition of autophosphorylation.

Piala AT, Moon TM, Akella R, He H, Cobb MH, Goldsmith EJ.

Sci Signal. 2014 May 6;7(324):ra41. doi: 10.1126/scisignal.2005050.


WNK1-OSR1 kinase-mediated phospho-activation of Na+-K+-2Cl- cotransporter facilitates glioma migration.

Zhu W, Begum G, Pointer K, Clark PA, Yang SS, Lin SH, Kahle KT, Kuo JS, Sun D.

Mol Cancer. 2014 Feb 20;13:31. doi: 10.1186/1476-4598-13-31.


Regulation of OSR1 and the sodium, potassium, two chloride cotransporter by convergent signals.

Sengupta S, Lorente-Rodríguez A, Earnest S, Stippec S, Guo X, Trudgian DC, Mirzaei H, Cobb MH.

Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):18826-31. doi: 10.1073/pnas.1318676110. Epub 2013 Nov 4.


Regulation of NKCC2 activity by inhibitory SPAK isoforms: KS-SPAK is a more potent inhibitor than SPAK2.

Park HJ, Curry JN, McCormick JA.

Am J Physiol Renal Physiol. 2013 Dec 15;305(12):F1687-96. doi: 10.1152/ajprenal.00211.2013. Epub 2013 Oct 16.


Aldosterone acutely stimulates NCC activity via a SPAK-mediated pathway.

Ko B, Mistry AC, Hanson L, Mallick R, Wynne BM, Thai TL, Bailey JL, Klein JD, Hoover RS.

Am J Physiol Renal Physiol. 2013 Sep 1;305(5):F645-52. doi: 10.1152/ajprenal.00053.2013. Epub 2013 Jun 5.


WNK1 protein kinase regulates embryonic cardiovascular development through the OSR1 signaling cascade.

Xie J, Yoon J, Yang SS, Lin SH, Huang CL.

J Biol Chem. 2013 Mar 22;288(12):8566-74. doi: 10.1074/jbc.M113.451575. Epub 2013 Feb 5.


A minor role of WNK3 in regulating phosphorylation of renal NKCC2 and NCC co-transporters in vivo.

Oi K, Sohara E, Rai T, Misawa M, Chiga M, Alessi DR, Sasaki S, Uchida S.

Biol Open. 2012 Feb 15;1(2):120-7. doi: 10.1242/bio.2011048. Epub 2011 Nov 24.


Transepithelial bicarbonate secretion: lessons from the pancreas.

Park HW, Lee MG.

Cold Spring Harb Perspect Med. 2012 Oct 1;2(10). pii: a009571. doi: 10.1101/cshperspect.a009571.


Interactions with WNK (with no lysine) family members regulate oxidative stress response 1 and ion co-transporter activity.

Sengupta S, Tu SW, Wedin K, Earnest S, Stippec S, Luby-Phelps K, Cobb MH.

J Biol Chem. 2012 Nov 2;287(45):37868-79. doi: 10.1074/jbc.M112.398750. Epub 2012 Sep 18.


The Drosophila NKCC Ncc69 is required for normal renal tubule function.

Rodan AR, Baum M, Huang CL.

Am J Physiol Cell Physiol. 2012 Oct 15;303(8):C883-94. doi: 10.1152/ajpcell.00201.2012. Epub 2012 Aug 22.


Taurine inhibits K+-Cl- cotransporter KCC2 to regulate embryonic Cl- homeostasis via with-no-lysine (WNK) protein kinase signaling pathway.

Inoue K, Furukawa T, Kumada T, Yamada J, Wang T, Inoue R, Fukuda A.

J Biol Chem. 2012 Jun 15;287(25):20839-50. doi: 10.1074/jbc.M111.319418. Epub 2012 Apr 27.


Molecular mechanism of pancreatic and salivary gland fluid and HCO3 secretion.

Lee MG, Ohana E, Park HW, Yang D, Muallem S.

Physiol Rev. 2012 Jan;92(1):39-74. doi: 10.1152/physrev.00011.2011. Review.

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