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Items: 7


Recombinant rabbit single-chain antibodies bind to the catalytic and C-terminal domains of HIV-1 integrase protein and strongly inhibit HIV-1 replication.

da Silva FA, Li M, Rato S, Maia S, Malhó R, Warren K, Harrich D, Craigie R, Barbas C 3rd, Goncalves J.

Biotechnol Appl Biochem. 2012 Sep-Oct;59(5):353-66. doi: 10.1002/bab.1034. Epub 2012 Oct 10.


In vitro evolution of an HIV integrase binding protein from a library of C-terminal domain γS-crystallin variants.

Moody IS, Verde SC, Overstreet CM, Edward Robinson W Jr, Weiss GA.

Bioorg Med Chem Lett. 2012 Sep 1;22(17):5584-9. doi: 10.1016/j.bmcl.2012.07.008. Epub 2012 Jul 10.


Architecture of a full-length retroviral integrase monomer and dimer, revealed by small angle X-ray scattering and chemical cross-linking.

Bojja RS, Andrake MD, Weigand S, Merkel G, Yarychkivska O, Henderson A, Kummerling M, Skalka AM.

J Biol Chem. 2011 May 13;286(19):17047-59. doi: 10.1074/jbc.M110.212571. Epub 2011 Mar 15.


The HIV-1 integrase α4-helix involved in LTR-DNA recognition is also a highly antigenic peptide element.

Azzi S, Parissi V, Maroun RG, Eid P, Mauffret O, Fermandjian S.

PLoS One. 2010 Dec 30;5(12):e16001. doi: 10.1371/journal.pone.0016001.


A cooperative and specific DNA-binding mode of HIV-1 integrase depends on the nature of the metallic cofactor and involves the zinc-containing N-terminal domain.

Carayon K, Leh H, Henry E, Simon F, Mouscadet JF, Deprez E.

Nucleic Acids Res. 2010 Jun;38(11):3692-708. doi: 10.1093/nar/gkq087. Epub 2010 Feb 17.


HIV-1 IN inhibitors: 2010 update and perspectives.

Marchand C, Maddali K, Métifiot M, Pommier Y.

Curr Top Med Chem. 2009;9(11):1016-37. Review.


Posttranslational acetylation of the human immunodeficiency virus type 1 integrase carboxyl-terminal domain is dispensable for viral replication.

Topper M, Luo Y, Zhadina M, Mohammed K, Smith L, Muesing MA.

J Virol. 2007 Mar;81(6):3012-7. Epub 2006 Dec 20.

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