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Results: 1 to 20 of 52

1.

Activity of ADAM17 (a disintegrin and metalloprotease 17) is regulated by its noncatalytic domains and secondary structure of its substrates.

Stawikowska R, Cudic M, Giulianotti M, Houghten RA, Fields GB, Minond D.

J Biol Chem. 2013 Aug 2;288(31):22871-9. doi: 10.1074/jbc.M113.462267. Epub 2013 Jun 18.

PMID:
23779109
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Structural snapshots reveal distinct mechanisms of procaspase-3 and -7 activation.

Thomsen ND, Koerber JT, Wells JA.

Proc Natl Acad Sci U S A. 2013 May 21;110(21):8477-82. doi: 10.1073/pnas.1306759110. Epub 2013 May 6.

PMID:
23650375
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Substrate and inhibitor-induced dimerization and cooperativity in caspase-1 but not caspase-3.

Datta D, McClendon CL, Jacobson MP, Wells JA.

J Biol Chem. 2013 Apr 5;288(14):9971-81. doi: 10.1074/jbc.M112.426460. Epub 2013 Feb 5.

PMID:
23386603
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Ordering a dynamic protein via a small-molecule stabilizer.

Wang N, Majmudar CY, Pomerantz WC, Gagnon JK, Sadowsky JD, Meagher JL, Johnson TK, Stuckey JA, Brooks CL 3rd, Wells JA, Mapp AK.

J Am Chem Soc. 2013 Mar 6;135(9):3363-6. doi: 10.1021/ja3122334. Epub 2013 Feb 22.

PMID:
23384013
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Mechanistic and structural understanding of uncompetitive inhibitors of caspase-6.

Heise CE, Murray J, Augustyn KE, Bravo B, Chugha P, Cohen F, Giannetti AM, Gibbons P, Hannoush RN, Hearn BR, Jaishankar P, Ly CQ, Shah K, Stanger K, Steffek M, Tang Y, Zhao X, Lewcock JW, Renslo AR, Flygare J, Arkin MR.

PLoS One. 2012;7(12):e50864. doi: 10.1371/journal.pone.0050864. Epub 2012 Dec 5.

PMID:
23227217
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Death by caspase dimerization.

MacKenzie SH, Clark AC.

Adv Exp Med Biol. 2012;747:55-73. doi: 10.1007/978-1-4614-3229-6_4. Review.

PMID:
22949111
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Discovery of novel inhibitors of a disintegrin and metalloprotease 17 (ADAM17) using glycosylated and non-glycosylated substrates.

Minond D, Cudic M, Bionda N, Giulianotti M, Maida L, Houghten RA, Fields GB.

J Biol Chem. 2012 Oct 19;287(43):36473-87. doi: 10.1074/jbc.M112.389114. Epub 2012 Aug 27.

PMID:
22927435
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Zinc-mediated allosteric inhibition of caspase-6.

Velázquez-Delgado EM, Hardy JA.

J Biol Chem. 2012 Oct 19;287(43):36000-11. doi: 10.1074/jbc.M112.397752. Epub 2012 Aug 13. Erratum in: J Biol Chem. 2013 Apr 19;288(16):11508.

PMID:
22891250
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Fibrils colocalize caspase-3 with procaspase-3 to foster maturation.

Zorn JA, Wolan DW, Agard NJ, Wells JA.

J Biol Chem. 2012 Sep 28;287(40):33781-95. Epub 2012 Aug 7.

PMID:
22872644
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

A class of allosteric caspase inhibitors identified by high-throughput screening.

Feldman T, Kabaleeswaran V, Jang SB, Antczak C, Djaballah H, Wu H, Jiang X.

Mol Cell. 2012 Aug 24;47(4):585-95. doi: 10.1016/j.molcel.2012.06.007. Epub 2012 Jul 12.

PMID:
22795132
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Fine-tuning multiprotein complexes using small molecules.

Thompson AD, Dugan A, Gestwicki JE, Mapp AK.

ACS Chem Biol. 2012 Aug 17;7(8):1311-20. doi: 10.1021/cb300255p. Epub 2012 Jul 23. Review.

PMID:
22725693
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Allosteric modulation of caspase 3 through mutagenesis.

Walters J, Schipper JL, Swartz P, Mattos C, Clark AC.

Biosci Rep. 2012 Aug;32(4):401-11. doi: 10.1042/BSR20120037.

PMID:
22607239
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Phosphorylation regulates assembly of the caspase-6 substrate-binding groove.

Velázquez-Delgado EM, Hardy JA.

Structure. 2012 Apr 4;20(4):742-51. doi: 10.1016/j.str.2012.02.003. Epub 2012 Apr 3.

PMID:
22483120
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

New approaches for dissecting protease functions to improve probe development and drug discovery.

Deu E, Verdoes M, Bogyo M.

Nat Struct Mol Biol. 2012 Jan 5;19(1):9-16. doi: 10.1038/nsmb.2203. Review.

PMID:
22218294
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Crystal structure of the mucosa-associated lymphoid tissue lymphoma translocation 1 (MALT1) paracaspase region.

Yu JW, Jeffrey PD, Ha JY, Yang X, Shi Y.

Proc Natl Acad Sci U S A. 2011 Dec 27;108(52):21004-9. doi: 10.1073/pnas.1111708108. Epub 2011 Dec 7.

PMID:
22158899
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Selective and cell-active inhibitors of the USP1/ UAF1 deubiquitinase complex reverse cisplatin resistance in non-small cell lung cancer cells.

Chen J, Dexheimer TS, Ai Y, Liang Q, Villamil MA, Inglese J, Maloney DJ, Jadhav A, Simeonov A, Zhuang Z.

Chem Biol. 2011 Nov 23;18(11):1390-400. doi: 10.1016/j.chembiol.2011.08.014.

PMID:
22118673
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Identification of specific tethered inhibitors for caspase-5.

Gao J, Wells JA.

Chem Biol Drug Des. 2012 Feb;79(2):209-15. doi: 10.1111/j.1747-0285.2011.01261.x. Epub 2011 Nov 28.

PMID:
22014003
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Berkeleyones and related meroterpenes from a deep water acid mine waste fungus that inhibit the production of interleukin 1-β from induced inflammasomes.

Stierle DB, Stierle AA, Patacini B, McIntyre K, Girtsman T, Bolstad E.

J Nat Prod. 2011 Oct 28;74(10):2273-7. doi: 10.1021/np2003066. Epub 2011 Sep 14.

PMID:
21916432
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Peptide from the C-terminal domain of tissue inhibitor of matrix metalloproteinases-2 (TIMP-2) inhibits membrane activation of matrix metalloproteinase-2 (MMP-2).

Xu X, Mikhailova M, Chen Z, Pal S, Robichaud TK, Lafer EM, Baber S, Steffensen B.

Matrix Biol. 2011 Sep;30(7-8):404-12. doi: 10.1016/j.matbio.2011.07.001. Epub 2011 Aug 4.

PMID:
21839835
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

A bifunctional allosteric site in the dimer interface of procaspase-3.

Schipper JL, MacKenzie SH, Sharma A, Clark AC.

Biophys Chem. 2011 Nov;159(1):100-9. doi: 10.1016/j.bpc.2011.05.013. Epub 2011 May 25.

PMID:
21645959
[PubMed - indexed for MEDLINE]
Free PMC Article

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