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2-Aryl-8-aza-3-deazaadenosine analogues of 5'-O-[N-(salicyl)sulfamoyl]adenosine: Nucleoside antibiotics that block siderophore biosynthesis in Mycobacterium tuberculosis.

Krajczyk A, Zeidler J, Januszczyk P, Dawadi S, Boshoff HI, Barry CE 3rd, Ostrowski T, Aldrich CC.

Bioorg Med Chem. 2016 Jul 15;24(14):3133-43. doi: 10.1016/j.bmc.2016.05.037. Epub 2016 May 20.


Synthesis and pharmacological evaluation of nucleoside prodrugs designed to target siderophore biosynthesis in Mycobacterium tuberculosis.

Dawadi S, Kawamura S, Rubenstein A, Remmel R, Aldrich CC.

Bioorg Med Chem. 2016 Mar 15;24(6):1314-21. doi: 10.1016/j.bmc.2016.02.002. Epub 2016 Feb 3.


Structural Biology of Nonribosomal Peptide Synthetases.

Miller BR, Gulick AM.

Methods Mol Biol. 2016;1401:3-29. doi: 10.1007/978-1-4939-3375-4_1.


Cyclic diguanylate monophosphate directly binds to human siderocalin and inhibits its antibacterial activity.

Li W, Cui T, Hu L, Wang Z, Li Z, He ZG.

Nat Commun. 2015 Sep 22;6:8330. doi: 10.1038/ncomms9330.


Synthesis and Pharmacokinetic Evaluation of Siderophore Biosynthesis Inhibitors for Mycobacterium tuberculosis.

Nelson KM, Viswanathan K, Dawadi S, Duckworth BP, Boshoff HI, Barry CE 3rd, Aldrich CC.

J Med Chem. 2015 Jul 23;58(14):5459-75. doi: 10.1021/acs.jmedchem.5b00391. Epub 2015 Jul 9.


Breaking a pathogen's iron will: Inhibiting siderophore production as an antimicrobial strategy.

Lamb AL.

Biochim Biophys Acta. 2015 Aug;1854(8):1054-70. doi: 10.1016/j.bbapap.2015.05.001. Epub 2015 May 10. Review.


Investigation and conformational analysis of fluorinated nucleoside antibiotics targeting siderophore biosynthesis.

Dawadi S, Viswanathan K, Boshoff HI, Barry CE 3rd, Aldrich CC.

J Org Chem. 2015 May 15;80(10):4835-50. doi: 10.1021/acs.joc.5b00550. Epub 2015 Apr 30.


Lipidomic analysis links mycobactin synthase K to iron uptake and virulence in M. tuberculosis.

Madigan CA, Martinot AJ, Wei JR, Madduri A, Cheng TY, Young DC, Layre E, Murry JP, Rubin EJ, Moody DB.

PLoS Pathog. 2015 Mar 27;11(3):e1004792. doi: 10.1371/journal.ppat.1004792. eCollection 2015 Mar.


Improved Synthesis of Biotinol-5'-AMP: Implications for Antibacterial Discovery.

Tieu W, Polyak SW, Paparella AS, Yap MY, Soares da Costa TP, Ng B, Wang G, Lumb R, Bell JM, Turnidge JD, Wilce MC, Booker GW, Abell AD.

ACS Med Chem Lett. 2014 Dec 11;6(2):216-20. doi: 10.1021/ml500475n. eCollection 2015 Feb 12.


Active site-directed proteomic probes for adenylation domains in nonribosomal peptide synthetases.

Konno S, Ishikawa F, Suzuki T, Dohmae N, Burkart MD, Kakeya H.

Chem Commun (Camb). 2015 Feb 11;51(12):2262-5. doi: 10.1039/c4cc09412c.


Expanding the results of a high throughput screen against an isochorismate-pyruvate lyase to enzymes of a similar scaffold or mechanism.

Meneely KM, Luo Q, Riley AP, Taylor B, Roy A, Stein RL, Prisinzano TE, Lamb AL.

Bioorg Med Chem. 2014 Nov 1;22(21):5961-9. doi: 10.1016/j.bmc.2014.09.010. Epub 2014 Sep 16.


General platform for systematic quantitative evaluation of small-molecule permeability in bacteria.

Davis TD, Gerry CJ, Tan DS.

ACS Chem Biol. 2014 Nov 21;9(11):2535-44. doi: 10.1021/cb5003015. Epub 2014 Sep 8.


Protein expression and transcription profiles of three strains of Aeromonas salmonicida ssp. salmonicida under normal and iron-limited culture conditions.

Menanteau-Ledouble S, Kattlun J, Nöbauer K, El-Matbouli M.

Proteome Sci. 2014 May 19;12:29. doi: 10.1186/1477-5956-12-29. eCollection 2014.


Identification of inhibitors of PvdQ, an enzyme involved in the synthesis of the siderophore pyoverdine.

Wurst JM, Drake EJ, Theriault JR, Jewett IT, VerPlank L, Perez JR, Dandapani S, Palmer M, Moskowitz SM, Schreiber SL, Munoz B, Gulick AM.

ACS Chem Biol. 2014 Jul 18;9(7):1536-44. doi: 10.1021/cb5001586. Epub 2014 May 21.


Biotrophy-specific downregulation of siderophore biosynthesis in Colletotrichum graminicola is required for modulation of immune responses of maize.

Albarouki E, Schafferer L, Ye F, von Wirén N, Haas H, Deising HB.

Mol Microbiol. 2014 Apr;92(2):338-55. doi: 10.1111/mmi.12561. Epub 2014 Mar 17.


Reaction intermediate analogues as bisubstrate inhibitors of pantothenate synthetase.

Xu Z, Yin W, Martinelli LK, Evans J, Chen J, Yu Y, Wilson DJ, Mizrahi V, Qiao C, Aldrich CC.

Bioorg Med Chem. 2014 Mar 1;22(5):1726-35. doi: 10.1016/j.bmc.2014.01.017. Epub 2014 Jan 23.


Establishment and validation of whole-cell based fluorescence assays to identify anti-mycobacterial compounds using the Acanthamoeba castellanii-Mycobacterium marinum host-pathogen system.

Kicka S, Trofimov V, Harrison C, Ouertatani-Sakouhi H, McKinney J, Scapozza L, Hilbi H, Cosson P, Soldati T.

PLoS One. 2014 Jan 31;9(1):e87834. doi: 10.1371/journal.pone.0087834. eCollection 2014.


Self-poisoning of Mycobacterium tuberculosis by interrupting siderophore recycling.

Jones CM, Wells RM, Madduri AV, Renfrow MB, Ratledge C, Moody DB, Niederweis M.

Proc Natl Acad Sci U S A. 2014 Feb 4;111(5):1945-50. doi: 10.1073/pnas.1311402111. Epub 2014 Jan 13.


4-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(4-methoxypyridin-2-yl)piperazine-1-carbothioamide (ML267), a potent inhibitor of bacterial phosphopantetheinyl transferase that attenuates secondary metabolism and thwarts bacterial growth.

Foley TL, Rai G, Yasgar A, Daniel T, Baker HL, Attene-Ramos M, Kosa NM, Leister W, Burkart MD, Jadhav A, Simeonov A, Maloney DJ.

J Med Chem. 2014 Feb 13;57(3):1063-78. doi: 10.1021/jm401752p. Epub 2014 Jan 22.


Baulamycins A and B, broad-spectrum antibiotics identified as inhibitors of siderophore biosynthesis in Staphylococcus aureus and Bacillus anthracis.

Tripathi A, Schofield MM, Chlipala GE, Schultz PJ, Yim I, Newmister SA, Nusca TD, Scaglione JB, Hanna PC, Tamayo-Castillo G, Sherman DH.

J Am Chem Soc. 2014 Jan 29;136(4):1579-86. doi: 10.1021/ja4115924. Epub 2014 Jan 17. Erratum in: J Am Chem Soc. 2014 Jul 23;136(29):10541.

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