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Items: 20


Monitoring Cr intermediates and reactive oxygen species with fluorescent probes during chromate reduction.

DeLoughery Z, Luczak MW, Zhitkovich A.

Chem Res Toxicol. 2014 May 19;27(5):843-51. doi: 10.1021/tx500028x. Epub 2014 Mar 31.


NDRG1 deficiency attenuates fetal growth and the intrauterine response to hypoxic injury.

Larkin J, Chen B, Shi XH, Mishima T, Kokame K, Barak Y, Sadovsky Y.

Endocrinology. 2014 Mar;155(3):1099-106. doi: 10.1210/en.2013-1425. Epub 2013 Jan 1.


The expression and localization of N-myc downstream-regulated gene 1 in human trophoblasts.

Shi XH, Larkin JC, Chen B, Sadovsky Y.

PLoS One. 2013 Sep 16;8(9):e75473. doi: 10.1371/journal.pone.0075473. eCollection 2013.


Chromium(VI) causes interstrand DNA cross-linking in vitro but shows no hypersensitivity in cross-link repair-deficient human cells.

Morse JL, Luczak MW, Zhitkovich A.

Chem Res Toxicol. 2013 Oct 21;26(10):1591-8. doi: 10.1021/tx400293s. Epub 2013 Oct 8.


Regulation of vitamin C homeostasis during deficiency.

Lindblad M, Tveden-Nyborg P, Lykkesfeldt J.

Nutrients. 2013 Jul 25;5(8):2860-79. doi: 10.3390/nu5082860. Review.


Metabolism of Cr(VI) by ascorbate but not glutathione is a low oxidant-generating process.

Wong V, Armknecht S, Zhitkovich A.

J Trace Elem Med Biol. 2012 Jun;26(2-3):192-6. doi: 10.1016/j.jtemb.2012.04.016. Epub 2012 May 7.


Environmental chemical exposures and human epigenetics.

Hou L, Zhang X, Wang D, Baccarelli A.

Int J Epidemiol. 2012 Feb;41(1):79-105. doi: 10.1093/ije/dyr154. Epub 2011 Dec 13.


Bioavailability, intracellular mobilization of nickel, and HIF-1α activation in human lung epithelial cells exposed to metallic nickel and nickel oxide nanoparticles.

Pietruska JR, Liu X, Smith A, McNeil K, Weston P, Zhitkovich A, Hurt R, Kane AB.

Toxicol Sci. 2011 Nov;124(1):138-48. doi: 10.1093/toxsci/kfr206. Epub 2011 Aug 9.


Chromium in drinking water: sources, metabolism, and cancer risks.

Zhitkovich A.

Chem Res Toxicol. 2011 Oct 17;24(10):1617-29. doi: 10.1021/tx200251t. Epub 2011 Jul 28. Review.


Epigenetics in metal carcinogenesis: nickel, arsenic, chromium and cadmium.

Arita A, Costa M.

Metallomics. 2009;1(3):222-8. doi: 10.1039/b903049b. Review.


Nickel ions inhibit histone demethylase JMJD1A and DNA repair enzyme ABH2 by replacing the ferrous iron in the catalytic centers.

Chen H, Giri NC, Zhang R, Yamane K, Zhang Y, Maroney M, Costa M.

J Biol Chem. 2010 Mar 5;285(10):7374-83. doi: 10.1074/jbc.M109.058503. Epub 2009 Dec 30.


Cobalt-induced oxidant stress in cultured endothelial cells: prevention by ascorbate in relation to HIF-1alpha.

Qiao H, Li L, Qu ZC, May JM.

Biofactors. 2009 May-Jun;35(3):306-13. doi: 10.1002/biof.43.


Oxidized lipoprotein induces the macrophage ascorbate transporter (SVCT2): protection by intracellular ascorbate against oxidant stress and apoptosis.

Chi X, May JM.

Arch Biochem Biophys. 2009 May 15;485(2):174-82. doi: 10.1016/ Epub 2009 Feb 28.


Metal ions-stimulated iron oxidation in hydroxylases facilitates stabilization of HIF-1 alpha protein.

Kaczmarek M, Cachau RE, Topol IA, Kasprzak KS, Ghio A, Salnikow K.

Toxicol Sci. 2009 Feb;107(2):394-403. doi: 10.1093/toxsci/kfn251. Epub 2008 Dec 13.


Regulation of hypoxia-inducible genes by ETS1 transcription factor.

Salnikow K, Aprelikova O, Ivanov S, Tackett S, Kaczmarek M, Karaczyn A, Yee H, Kasprzak KS, Niederhuber J.

Carcinogenesis. 2008 Aug;29(8):1493-9. doi: 10.1093/carcin/bgn088. Epub 2008 Apr 1.


Genetic and epigenetic mechanisms in metal carcinogenesis and cocarcinogenesis: nickel, arsenic, and chromium.

Salnikow K, Zhitkovich A.

Chem Res Toxicol. 2008 Jan;21(1):28-44. Epub 2007 Oct 30. Review.


Hypoxia-inducible factor-1alpha stabilization in nonhypoxic conditions: role of oxidation and intracellular ascorbate depletion.

Pagé EL, Chan DA, Giaccia AJ, Levine M, Richard DE.

Mol Biol Cell. 2008 Jan;19(1):86-94. Epub 2007 Oct 17.


The role of ascorbate in the modulation of HIF-1alpha protein and HIF-dependent transcription by chromium(VI) and nickel(II).

Kaczmarek M, Timofeeva OA, Karaczyn A, Malyguine A, Kasprzak KS, Salnikow K.

Free Radic Biol Med. 2007 Apr 15;42(8):1246-57. Epub 2007 Jan 19.


Ascorbate acts as a highly potent inducer of chromate mutagenesis and clastogenesis: linkage to DNA breaks in G2 phase by mismatch repair.

Reynolds M, Stoddard L, Bespalov I, Zhitkovich A.

Nucleic Acids Res. 2007;35(2):465-76. Epub 2006 Dec 14.


Cellular differentiation determines the expression of the hypoxia-inducible protein NDRG1 in pancreatic cancer.

Angst E, Sibold S, Tiffon C, Weimann R, Gloor B, Candinas D, Stroka D.

Br J Cancer. 2006 Aug 7;95(3):307-13. Epub 2006 Jul 11.

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