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Items: 17


Rapid binding of plasminogen to streptokinase in a catalytic complex reveals a three-step mechanism.

Verhamme IM, Bock PE.

J Biol Chem. 2014 Oct 3;289(40):28006-18. doi: 10.1074/jbc.M114.589077. Epub 2014 Aug 19.


Endocarditis and molecular imaging.

Panizzi P, Stone JR, Nahrendorf M.

J Nucl Cardiol. 2014 Jun;21(3):486-95. doi: 10.1007/s12350-014-9902-8. Epub 2014 May 6. Review. No abstract available.


Effect of zymogen domains and active site occupation on activation of prothrombin by von Willebrand factor-binding protein.

Kroh HK, Bock PE.

J Biol Chem. 2012 Nov 9;287(46):39149-57. doi: 10.1074/jbc.M112.415562. Epub 2012 Sep 25.


Development of coagulation factor probes for the identification of procoagulant circulating tumor cells.

Tormoen GW, Cianchetti FA, Bock PE, McCarty OJ.

Front Oncol. 2012 Sep 6;2:110. doi: 10.3389/fonc.2012.00110. eCollection 2012.


Exploring Staphylococcus aureus pathways to disease for vaccine development.

DeDent A, Kim HK, Missiakas D, Schneewind O.

Semin Immunopathol. 2012 Mar;34(2):317-33. doi: 10.1007/s00281-011-0299-z. Epub 2011 Dec 1. Review.


Notecarin D binds human factor V and factor Va with high affinity in the absence of membranes.

Newell-Caito JL, Laha M, Tharp AC, Creamer JI, Xu H, Maddur AA, Tans G, Bock PE.

J Biol Chem. 2011 Nov 4;286(44):38286-97. doi: 10.1074/jbc.M111.247122. Epub 2011 Sep 12.


In vivo detection of Staphylococcus aureus endocarditis by targeting pathogen-specific prothrombin activation.

Panizzi P, Nahrendorf M, Figueiredo JL, Panizzi J, Marinelli B, Iwamoto Y, Keliher E, Maddur AA, Waterman P, Kroh HK, Leuschner F, Aikawa E, Swirski FK, Pittet MJ, Hackeng TM, Fuentes-Prior P, Schneewind O, Bock PE, Weissleder R.

Nat Med. 2011 Aug 21;17(9):1142-6. doi: 10.1038/nm.2423.


Engineering streptokinase for generation of active site-labeled plasminogen analogs.

Laha M, Panizzi P, Nahrendorf M, Bock PE.

Anal Biochem. 2011 Aug 15;415(2):105-15. doi: 10.1016/j.ab.2011.04.025. Epub 2011 Apr 23.


Active site-labeled prothrombin inhibits prothrombinase in vitro and thrombosis in vivo.

Kroh HK, Panizzi P, Tchaikovski S, Baird TR, Wei N, Krishnaswamy S, Tans G, Rosing J, Furie B, Furie BC, Bock PE.

J Biol Chem. 2011 Jul 1;286(26):23345-56. doi: 10.1074/jbc.M111.230292. Epub 2011 Apr 29.


Inhibition of thrombin formation by active site mutated (S360A) activated protein C.

Nicolaes GA, Bock PE, Segers K, Wildhagen KC, Dahlbäck B, Rosing J.

J Biol Chem. 2010 Jul 23;285(30):22890-900. doi: 10.1074/jbc.M110.131029. Epub 2010 May 18.


Spatial distribution of factor Xa, thrombin, and fibrin(ogen) on thrombi at venous shear.

Berny MA, Munnix IC, Auger JM, Schols SE, Cosemans JM, Panizzi P, Bock PE, Watson SP, McCarty OJ, Heemskerk JW.

PLoS One. 2010 Apr 29;5(4):e10415. doi: 10.1371/journal.pone.0010415.


Von Willebrand factor-binding protein is a hysteretic conformational activator of prothrombin.

Kroh HK, Panizzi P, Bock PE.

Proc Natl Acad Sci U S A. 2009 May 12;106(19):7786-91. doi: 10.1073/pnas.0811750106. Epub 2009 Apr 28.


A novel mode of intervention with serine protease activity: targeting zymogen activation.

Blouse GE, Bøtkjaer KA, Deryugina E, Byszuk AA, Jensen JM, Mortensen KK, Quigley JP, Andreasen PA.

J Biol Chem. 2009 Feb 13;284(7):4647-57. doi: 10.1074/jbc.M804922200. Epub 2008 Dec 1.


Restricted active site docking by enzyme-bound substrate enforces the ordered cleavage of prothrombin by prothrombinase.

Hacisalihoglu A, Panizzi P, Bock PE, Camire RM, Krishnaswamy S.

J Biol Chem. 2007 Nov 9;282(45):32974-82. Epub 2007 Sep 11.


Exosites in the substrate specificity of blood coagulation reactions.

Bock PE, Panizzi P, Verhamme IM.

J Thromb Haemost. 2007 Jul;5 Suppl 1:81-94. Review.


Fibrinogen substrate recognition by staphylocoagulase.(pro)thrombin complexes.

Panizzi P, Friedrich R, Fuentes-Prior P, Richter K, Bock PE, Bode W.

J Biol Chem. 2006 Jan 13;281(2):1179-87. Epub 2005 Oct 17.


Structural basis for reduced staphylocoagulase-mediated bovine prothrombin activation.

Friedrich R, Panizzi P, Kawabata S, Bode W, Bock PE, Fuentes-Prior P.

J Biol Chem. 2006 Jan 13;281(2):1188-95. Epub 2005 Oct 17.

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