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Results: 20

1.

Sphingolipids: key regulators of apoptosis and pivotal players in cancer drug resistance.

Giussani P, Tringali C, Riboni L, Viani P, Venerando B.

Int J Mol Sci. 2014 Mar 12;15(3):4356-92. doi: 10.3390/ijms15034356.

PMID:
24625663
[PubMed - in process]
Free PMC Article
2.

Fingolimod (FTY720) stimulates ca(2+)/calcineurin signaling in fission yeast.

Hagihara K, Kita A, Mizukura A, Yao M, Kitai Y, Kunoh T, Masuko T, Matzno S, Chiba K, Sugiura R.

PLoS One. 2013 Dec 3;8(12):e81907. doi: 10.1371/journal.pone.0081907. eCollection 2013.

PMID:
24312601
[PubMed - in process]
Free PMC Article
3.

Gossypol-Induced Differentiation in Human Leukemia HL-60 Cells.

Wang WQ, Li R, Bai QX, Liu YH, Zhang WP, Wang JH, Wang Z, Li YF, Chen XQ, Huang GS.

Int J Biomed Sci. 2006 Dec;2(4):395-401.

PMID:
23675007
[PubMed]
Free PMC Article
4.

Protein phosphatase 2A: a target for anticancer therapy.

Perrotti D, Neviani P.

Lancet Oncol. 2013 May;14(6):e229-38. doi: 10.1016/S1470-2045(12)70558-2. Review.

PMID:
23639323
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Model of translational cancer research in multiple myeloma.

Yasui H, Ishida T, Maruyama R, Nojima M, Ikeda H, Suzuki H, Hayashi T, Shinomura Y, Imai K.

Cancer Sci. 2012 Nov;103(11):1907-12. doi: 10.1111/j.1349-7006.2012.02384.x. Epub 2012 Aug 17. Review.

PMID:
22809142
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Disparate in vivo efficacy of FTY720 in xenograft models of Philadelphia positive and negative B-lineage acute lymphoblastic leukemia.

Wallington-Beddoe CT, Don AS, Hewson J, Qiao Q, Papa RA, Lock RB, Bradstock KF, Bendall LJ.

PLoS One. 2012;7(5):e36429. doi: 10.1371/journal.pone.0036429. Epub 2012 May 3. Erratum in: PLoS One. 2012;7(8). doi: 10.1371/annotation/d7342840-682b-4ee2-bb41-7b41aa5dedf7.

PMID:
22570713
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Induction of brain tumor stem cell apoptosis by FTY720: a potential therapeutic agent for glioblastoma.

Estrada-Bernal A, Palanichamy K, Ray Chaudhury A, Van Brocklyn JR.

Neuro Oncol. 2012 Apr;14(4):405-15. doi: 10.1093/neuonc/nos005. Epub 2012 Feb 20.

PMID:
22351749
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

FTY720 increases CD74 expression and sensitizes mantle cell lymphoma cells to milatuzumab-mediated cell death.

Alinari L, Mahoney E, Patton J, Zhang X, Huynh L, Earl CT, Mani R, Mao Y, Yu B, Quinion C, Towns WH, Chen CS, Goldenberg DM, Blum KA, Byrd JC, Muthusamy N, Praetorius-Ibba M, Baiocchi RA.

Blood. 2011 Dec 22;118(26):6893-903. doi: 10.1182/blood-2011-06-363879. Epub 2011 Oct 31.

PMID:
22042694
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Sphingolipid-based drugs selectively kill cancer cells by down-regulating nutrient transporter proteins.

Romero Rosales K, Singh G, Wu K, Chen J, Janes MR, Lilly MB, Peralta ER, Siskind LJ, Bennett MJ, Fruman DA, Edinger AL.

Biochem J. 2011 Oct 15;439(2):299-311. doi: 10.1042/BJ20110853.

PMID:
21767261
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Small compound 6-O-angeloylplenolin induces mitotic arrest and exhibits therapeutic potentials in multiple myeloma.

Liu Y, Chen XQ, Liang HX, Zhang FX, Zhang B, Jin J, Chen YL, Cheng YX, Zhou GB.

PLoS One. 2011;6(7):e21930. doi: 10.1371/journal.pone.0021930. Epub 2011 Jul 6.

PMID:
21755010
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Sphingolipid signaling and hematopoietic malignancies: to the rheostat and beyond.

Loh KC, Baldwin D, Saba JD.

Anticancer Agents Med Chem. 2011 Nov;11(9):782-93. Review.

PMID:
21707493
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Pharmacological relevance and potential of sphingosine 1-phosphate in the vascular system.

Schuchardt M, Tölle M, Prüfer J, van der Giet M.

Br J Pharmacol. 2011 Jul;163(6):1140-62. doi: 10.1111/j.1476-5381.2011.01260.x. Review.

PMID:
21309759
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Cancer treatment strategies targeting sphingolipid metabolism.

Oskouian B, Saba JD.

Adv Exp Med Biol. 2010;688:185-205. Review.

PMID:
20919655
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cells.

Tonelli F, Lim KG, Loveridge C, Long J, Pitson SM, Tigyi G, Bittman R, Pyne S, Pyne NJ.

Cell Signal. 2010 Oct;22(10):1536-42. doi: 10.1016/j.cellsig.2010.05.022. Epub 2010 Jun 4.

PMID:
20570726
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

PI3K/p110{delta} is a novel therapeutic target in multiple myeloma.

Ikeda H, Hideshima T, Fulciniti M, Perrone G, Miura N, Yasui H, Okawa Y, Kiziltepe T, Santo L, Vallet S, Cristea D, Calabrese E, Gorgun G, Raje NS, Richardson P, Munshi NC, Lannutti BJ, Puri KD, Giese NA, Anderson KC.

Blood. 2010 Sep 2;116(9):1460-8. doi: 10.1182/blood-2009-06-222943. Epub 2010 May 26.

PMID:
20505158
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Targeting sphingolipid metabolism in head and neck cancer: rational therapeutic potentials.

Beckham TH, Elojeimy S, Cheng JC, Turner LS, Hoffman SR, Norris JS, Liu X.

Expert Opin Ther Targets. 2010 May;14(5):529-39. doi: 10.1517/14728221003752768. Review.

PMID:
20334489
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Immunomodulatory drug FTY720 induces regulatory CD4(+)CD25(+) T cells in vitro.

Zhou PJ, Wang H, Shi GH, Wang XH, Shen ZJ, Xu D.

Clin Exp Immunol. 2009 Jul;157(1):40-7. doi: 10.1111/j.1365-2249.2009.03942.x.

PMID:
19659769
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

FTY720 demonstrates promising preclinical activity for chronic lymphocytic leukemia and lymphoblastic leukemia/lymphoma.

Liu Q, Zhao X, Frissora F, Ma Y, Santhanam R, Jarjoura D, Lehman A, Perrotti D, Chen CS, Dalton JT, Muthusamy N, Byrd JC.

Blood. 2008 Jan 1;111(1):275-84. Epub 2007 Aug 29.

PMID:
17761520
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

FTY720, a new alternative for treating blast crisis chronic myelogenous leukemia and Philadelphia chromosome-positive acute lymphocytic leukemia.

Neviani P, Santhanam R, Oaks JJ, Eiring AM, Notari M, Blaser BW, Liu S, Trotta R, Muthusamy N, Gambacorti-Passerini C, Druker BJ, Cortes J, Marcucci G, Chen CS, Verrills NM, Roy DC, Caligiuri MA, Bloomfield CD, Byrd JC, Perrotti D.

J Clin Invest. 2007 Sep;117(9):2408-21.

PMID:
17717597
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

New frontiers in the treatment of multiple myeloma.

Hwang JJ, Ghobrial IM, Anderson KC.

ScientificWorldJournal. 2006 Dec 6;6:1475-503. Review.

PMID:
17160337
[PubMed - indexed for MEDLINE]
Free PMC Article

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