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Items: 11


Allelic variants of the Melanocortin 4 receptor (MC4R) gene in a South African study group.

Logan M, Van der Merwe MT, Dodgen TM, Myburgh R, Eloff A, Alessandrini M, Pepper MS.

Mol Genet Genomic Med. 2015 Oct 23;4(1):68-76. doi: 10.1002/mgg3.180. eCollection 2016 Jan.


Clinically relevant known and candidate genes for obesity and their overlap with human infertility and reproduction.

Butler MG, McGuire A, Manzardo AM.

J Assist Reprod Genet. 2015 Apr;32(4):495-508. doi: 10.1007/s10815-014-0411-0. Epub 2015 Jan 29. Review.


ROHHAD Syndrome: Reasons for Diagnostic Difficulties in Obesity.

Kocaay P, Şıklar Z, Çamtosun E, Kendirli T, Berberoğlu M.

J Clin Res Pediatr Endocrinol. 2014 Dec;6(4):254-7. doi: 10.4274/Jcrpe.1432.


Development of a high throughput screen for allosteric modulators of melanocortin-4 receptor signaling using a real time cAMP assay.

Pantel J, Williams SY, Mi D, Sebag J, Corbin JD, Weaver CD, Cone RD.

Eur J Pharmacol. 2011 Jun 11;660(1):139-47. doi: 10.1016/j.ejphar.2011.01.031. Epub 2011 Feb 4.


The melanocortin-4 receptor: physiology, pharmacology, and pathophysiology.

Tao YX.

Endocr Rev. 2010 Aug;31(4):506-43. doi: 10.1210/er.2009-0037. Epub 2010 Feb 26.


Pertussis toxin-sensitive signaling of melanocortin-4 receptors in hypothalamic GT1-7 cells defines agouti-related protein as a biased agonist.

Büch TR, Heling D, Damm E, Gudermann T, Breit A.

J Biol Chem. 2009 Sep 25;284(39):26411-20. doi: 10.1074/jbc.M109.039339. Epub 2009 Jul 31.


In silico mutagenesis: a case study of the melanocortin 4 receptor.

Bromberg Y, Overton J, Vaisse C, Leibel RL, Rost B.

FASEB J. 2009 Sep;23(9):3059-69. doi: 10.1096/fj.08-127530. Epub 2009 May 5.


Implications of gene-behavior interactions: prevention and intervention for obesity.

Bray MS.

Obesity (Silver Spring). 2008 Dec;16 Suppl 3:S72-8. doi: 10.1038/oby.2008.522.


Functional characterization and structural modeling of obesity associated mutations in the melanocortin 4 receptor.

Tan K, Pogozheva ID, Yeo GS, Hadaschik D, Keogh JM, Haskell-Leuvano C, O'Rahilly S, Mosberg HI, Farooqi IS.

Endocrinology. 2009 Jan;150(1):114-25. doi: 10.1210/en.2008-0721. Epub 2008 Sep 18.


SNAP: predict effect of non-synonymous polymorphisms on function.

Bromberg Y, Rost B.

Nucleic Acids Res. 2007;35(11):3823-35. Epub 2007 May 25.


Impact of GPCRs in clinical medicine: monogenic diseases, genetic variants and drug targets.

Insel PA, Tang CM, Hahntow I, Michel MC.

Biochim Biophys Acta. 2007 Apr;1768(4):994-1005. Epub 2006 Oct 5. Review.

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