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Spastin-interacting protein NA14/SSNA1 functions in cytokinesis and axon development.

Goyal U, Renvoisé B, Chang J, Blackstone C.

PLoS One. 2014 Nov 12;9(11):e112428. doi: 10.1371/journal.pone.0112428. eCollection 2014.


Pharmacologic rescue of axon growth defects in a human iPSC model of hereditary spastic paraplegia SPG3A.

Zhu PP, Denton KR, Pierson TM, Li XJ, Blackstone C.

Hum Mol Genet. 2014 Nov 1;23(21):5638-48. doi: 10.1093/hmg/ddu280. Epub 2014 Jun 6.


MicroRNAs in Experimental Models of Movement Disorders.

Lee ST, Kim M.

J Mov Disord. 2011 Oct;4(2):55-9. doi: 10.14802/jmd.11011. Epub 2011 Oct 30. Review.


Autoantibodies to Non-myelin Antigens as Contributors to the Pathogenesis of Multiple Sclerosis.

Levin MC, Lee S, Gardner LA, Shin Y, Douglas JN, Cooper C.

J Clin Cell Immunol. 2013 Jun 30;4. doi: 10.4172/2155-9899.1000148.


REEPs are membrane shaping adapter proteins that modulate specific g protein-coupled receptor trafficking by affecting ER cargo capacity.

Björk S, Hurt CM, Ho VK, Angelotti T.

PLoS One. 2013 Oct 2;8(10):e76366. doi: 10.1371/journal.pone.0076366. eCollection 2013. Erratum in: PLoS One. 2013;8(12). doi:10.1371/annotation/6f86410c-63c3-4fcd-b1cb-9fd8d2ea95d0.


Inhibition of TFG function causes hereditary axon degeneration by impairing endoplasmic reticulum structure.

Beetz C, Johnson A, Schuh AL, Thakur S, Varga RE, Fothergill T, Hertel N, Bomba-Warczak E, Thiele H, Nürnberg G, Altmüller J, Saxena R, Chapman ER, Dent EW, Nürnberg P, Audhya A.

Proc Natl Acad Sci U S A. 2013 Mar 26;110(13):5091-6. doi: 10.1073/pnas.1217197110. Epub 2013 Mar 11.


Spg20-/- mice reveal multimodal functions for Troyer syndrome protein spartin in lipid droplet maintenance, cytokinesis and BMP signaling.

Renvoisé B, Stadler J, Singh R, Bakowska JC, Blackstone C.

Hum Mol Genet. 2012 Aug 15;21(16):3604-18. doi: 10.1093/hmg/dds191. Epub 2012 May 22.


Emerging aspects of ER organization in root hair tip growth: lessons from RHD3 and Atlastin.

Zheng H, Chen J.

Plant Signal Behav. 2011 Nov;6(11):1710-3. doi: 10.4161/psb.6.11.17477. Epub 2011 Nov 1. Review.


Membrane fusion by the GTPase atlastin requires a conserved C-terminal cytoplasmic tail and dimerization through the middle domain.

Moss TJ, Andreazza C, Verma A, Daga A, McNew JA.

Proc Natl Acad Sci U S A. 2011 Jul 5;108(27):11133-8. doi: 10.1073/pnas.1105056108. Epub 2011 Jun 20.


The effect of HSP-causing mutations in SPG3A and NIPA1 on the assembly, trafficking, and interaction between atlastin-1 and NIPA1.

Botzolakis EJ, Zhao J, Gurba KN, Macdonald RL, Hedera P.

Mol Cell Neurosci. 2011 Jan;46(1):122-35. doi: 10.1016/j.mcn.2010.08.012. Epub 2010 Sep 21.


SPG20 protein spartin is recruited to midbodies by ESCRT-III protein Ist1 and participates in cytokinesis.

Renvoisé B, Parker RL, Yang D, Bakowska JC, Hurley JH, Blackstone C.

Mol Biol Cell. 2010 Oct 1;21(19):3293-303. doi: 10.1091/mbc.E09-10-0879. Epub 2010 Aug 18.


Mutation screening of spastin, atlastin, and REEP1 in hereditary spastic paraplegia.

McCorquodale DS 3rd, Ozomaro U, Huang J, Montenegro G, Kushman A, Citrigno L, Price J, Speziani F, Pericak-Vance MA, Züchner S.

Clin Genet. 2011 Jun;79(6):523-30. doi: 10.1111/j.1399-0004.2010.01501.x.


Novel SPG11 mutations in Asian kindreds and disruption of spatacsin function in the zebrafish.

Southgate L, Dafou D, Hoyle J, Li N, Kinning E, Critchley P, Németh AH, Talbot K, Bindu PS, Sinha S, Taly AB, Raghavendra S, Müller F, Maher ER, Trembath RC.

Neurogenetics. 2010 Oct;11(4):379-89. doi: 10.1007/s10048-010-0243-8.


Unique spectrum of SPAST variants in Estonian HSP patients: presence of benign missense changes but lack of exonic rearrangements.

Braschinsky M, Tamm R, Beetz C, Sachez-Ferrero E, Raukas E, Lüüs SM, Gross-Paju K, Boillot C, Canzian F, Metspalu A, Haldre S.

BMC Neurol. 2010 Mar 9;10:17. doi: 10.1186/1471-2377-10-17.


Hereditary spastic paraplegia proteins REEP1, spastin, and atlastin-1 coordinate microtubule interactions with the tubular ER network.

Park SH, Zhu PP, Parker RL, Blackstone C.

J Clin Invest. 2010 Apr;120(4):1097-110. doi: 10.1172/JCI40979.


Neuropathy target esterase is required for adult vertebrate axon maintenance.

Read DJ, Li Y, Chao MV, Cavanagh JB, Glynn P.

J Neurosci. 2009 Sep 16;29(37):11594-600. doi: 10.1523/JNEUROSCI.3007-09.2009.


The hereditary spastic paraplegia proteins NIPA1, spastin and spartin are inhibitors of mammalian BMP signalling.

Tsang HT, Edwards TL, Wang X, Connell JW, Davies RJ, Durrington HJ, O'Kane CJ, Luzio JP, Reid E.

Hum Mol Genet. 2009 Oct 15;18(20):3805-21. doi: 10.1093/hmg/ddp324. Epub 2009 Jul 20.


Endogenous spartin (SPG20) is recruited to endosomes and lipid droplets and interacts with the ubiquitin E3 ligases AIP4 and AIP5.

Edwards TL, Clowes VE, Tsang HT, Connell JW, Sanderson CM, Luzio JP, Reid E.

Biochem J. 2009 Sep 14;423(1):31-9. doi: 10.1042/BJ20082398. Erratum in: Biochem J. 2009 Nov 1;423(3):442.


Hereditary spastic paraplegia-associated mutations in the NIPA1 gene and its Caenorhabditis elegans homolog trigger neural degeneration in vitro and in vivo through a gain-of-function mechanism.

Zhao J, Matthies DS, Botzolakis EJ, Macdonald RL, Blakely RD, Hedera P.

J Neurosci. 2008 Dec 17;28(51):13938-51. doi: 10.1523/JNEUROSCI.4668-08.2008.


Structural basis for midbody targeting of spastin by the ESCRT-III protein CHMP1B.

Yang D, Rismanchi N, Renvoisé B, Lippincott-Schwartz J, Blackstone C, Hurley JH.

Nat Struct Mol Biol. 2008 Dec;15(12):1278-86. doi: 10.1038/nsmb.1512. Epub 2008 Nov 9.

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