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Items: 1 to 20 of 51

1.

Signal Transduction Pathways of EMT Induced by TGF-β, SHH, and WNT and Their Crosstalks.

Zhang J, Tian XJ, Xing J.

J Clin Med. 2016 Mar 28;5(4). pii: E41. doi: 10.3390/jcm5040041. Review.

2.

FGFR1 promotes the stem cell-like phenotype of FGFR1-amplified non-small cell lung cancer cells through the Hedgehog pathway.

Ji W, Yu Y, Li Z, Wang G, Li F, Xia W, Lu S.

Oncotarget. 2016 Mar 22;7(12):15118-34. doi: 10.18632/oncotarget.7701.

3.

Survivin, a novel target of the Hedgehog/GLI signaling pathway in human tumor cells.

Vlčková K, Ondrušová L, Vachtenheim J, Réda J, Dundr P, Zadinová M, Žáková P, Poučková P.

Cell Death Dis. 2016 Jan 14;7:e2048. doi: 10.1038/cddis.2015.389.

4.

Gli1-Mediated Regulation of Sox2 Facilitates Self-Renewal of Stem-Like Cells and Confers Resistance to EGFR Inhibitors in Non-Small Cell Lung Cancer.

Bora-Singhal N, Perumal D, Nguyen J, Chellappan S.

Neoplasia. 2015 Jul;17(7):538-51. doi: 10.1016/j.neo.2015.07.001.

5.

A shift in anterior-posterior positional information underlies the fin-to-limb evolution.

Onimaru K, Kuraku S, Takagi W, Hyodo S, Sharpe J, Tanaka M.

Elife. 2015 Aug 18;4. doi: 10.7554/eLife.07048.

6.

Pharmacological GLI2 inhibition prevents myofibroblast cell-cycle progression and reduces kidney fibrosis.

Kramann R, Fleig SV, Schneider RK, Fabian SL, DiRocco DP, Maarouf O, Wongboonsin J, Ikeda Y, Heckl D, Chang SL, Rennke HG, Waikar SS, Humphreys BD.

J Clin Invest. 2015 Aug 3;125(8):2935-51. doi: 10.1172/JCI74929. Epub 2015 Jul 20.

7.

HEDGEHOG/GLI-E2F1 axis modulates iASPP expression and function and regulates melanoma cell growth.

Pandolfi S, Montagnani V, Lapucci A, Stecca B.

Cell Death Differ. 2015 Dec;22(12):2006-19. doi: 10.1038/cdd.2015.56. Epub 2015 May 29.

8.

GLI2 inhibition abrogates human leukemia stem cell dormancy.

Sadarangani A, Pineda G, Lennon KM, Chun HJ, Shih A, Schairer AE, Court AC, Goff DJ, Prashad SL, Geron I, Wall R, McPherson JD, Moore RA, Pu M, Bao L, Jackson-Fisher A, Munchhof M, VanArsdale T, Reya T, Morris SR, Minden MD, Messer K, Mikkola HK, Marra MA, Hudson TJ, Jamieson CH.

J Transl Med. 2015 Mar 21;13:98. doi: 10.1186/s12967-015-0453-9.

9.

The heterotrimeric kinesin-2 complex interacts with and regulates GLI protein function.

Carpenter BS, Barry RL, Verhey KJ, Allen BL.

J Cell Sci. 2015 Mar 1;128(5):1034-50. doi: 10.1242/jcs.162552. Epub 2015 Jan 14.

10.

Lack of centrioles and primary cilia in STIL(-/-) mouse embryos.

David A, Liu F, Tibelius A, Vulprecht J, Wald D, Rothermel U, Ohana R, Seitel A, Metzger J, Ashery-Padan R, Meinzer HP, Gröne HJ, Izraeli S, Krämer A.

Cell Cycle. 2014;13(18):2859-68. doi: 10.4161/15384101.2014.946830.

11.

A de novo 10.79 Mb interstitial deletion at 2q13q14.2 involving PAX8 causing hypothyroidism and mullerian agenesis: a novel case report and literature review.

Ma D, Marion R, Punjabi NP, Pereira E, Samanich J, Agarwal C, Li J, Huang CK, Ramesh KH, Cannizzaro LA, Naeem R.

Mol Cytogenet. 2014 Nov 26;7(1):85. doi: 10.1186/s13039-014-0085-4. eCollection 2014.

12.

Repurposing the antihelmintic mebendazole as a hedgehog inhibitor.

Larsen AR, Bai RY, Chung JH, Borodovsky A, Rudin CM, Riggins GJ, Bunz F.

Mol Cancer Ther. 2015 Jan;14(1):3-13. doi: 10.1158/1535-7163.MCT-14-0755-T. Epub 2014 Nov 5.

13.

Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition.

Tang Y, Gholamin S, Schubert S, Willardson MI, Lee A, Bandopadhayay P, Bergthold G, Masoud S, Nguyen B, Vue N, Balansay B, Yu F, Oh S, Woo P, Chen S, Ponnuswami A, Monje M, Atwood SX, Whitson RJ, Mitra S, Cheshier SH, Qi J, Beroukhim R, Tang JY, Wechsler-Reya R, Oro AE, Link BA, Bradner JE, Cho YJ.

Nat Med. 2014 Jul;20(7):732-40. doi: 10.1038/nm.3613. Epub 2014 Jun 29.

14.

Structural basis of SUFU-GLI interaction in human Hedgehog signalling regulation.

Cherry AL, Finta C, Karlström M, Jin Q, Schwend T, Astorga-Wells J, Zubarev RA, Del Campo M, Criswell AR, de Sanctis D, Jovine L, Toftgård R.

Acta Crystallogr D Biol Crystallogr. 2013 Dec;69(Pt 12):2563-79. doi: 10.1107/S0907444913028473. Epub 2013 Nov 19.

15.

Sonic Hedgehog Signaling and VACTERL Association.

Ngan ES, Kim KH, Hui CC.

Mol Syndromol. 2013 Feb;4(1-2):32-45. doi: 10.1159/000345725.

16.

Functional characterization of a heterozygous GLI2 missense mutation in patients with multiple pituitary hormone deficiency.

Flemming GM, Klammt J, Ambler G, Bao Y, Blum WF, Cowell C, Donaghue K, Howard N, Kumar A, Sanchez J, Stobbe H, Pfäffle RW.

J Clin Endocrinol Metab. 2013 Mar;98(3):E567-75. doi: 10.1210/jc.2012-3224. Epub 2013 Feb 13.

17.

Inflammation and Gli2 suppress gastrin gene expression in a murine model of antral hyperplasia.

Saqui-Salces M, Covés-Datson E, Veniaminova NA, Waghray M, Syu LJ, Dlugosz AA, Merchant JL.

PLoS One. 2012;7(10):e48039. doi: 10.1371/journal.pone.0048039. Epub 2012 Oct 24.

18.

Small noncoding differentially methylated copy-number variants, including lncRNA genes, cause a lethal lung developmental disorder.

Szafranski P, Dharmadhikari AV, Brosens E, Gurha P, Kolodziejska KE, Zhishuo O, Dittwald P, Majewski T, Mohan KN, Chen B, Person RE, Tibboel D, de Klein A, Pinner J, Chopra M, Malcolm G, Peters G, Arbuckle S, Guiang SF 3rd, Hustead VA, Jessurun J, Hirsch R, Witte DP, Maystadt I, Sebire N, Fisher R, Langston C, Sen P, Stankiewicz P.

Genome Res. 2013 Jan;23(1):23-33. doi: 10.1101/gr.141887.112. Epub 2012 Oct 3.

19.

GLI2 regulates TGF-β1 in human CD4+ T cells: implications in cancer and HIV pathogenesis.

Furler RL, Uittenbogaart CH.

PLoS One. 2012;7(7):e40874. doi: 10.1371/journal.pone.0040874. Epub 2012 Jul 31.

20.

Comparison of mutation findings in ZIC2 between microform and classical holoprosencephaly in a Brazilian cohort.

Ribeiro LA, Roessler E, Hu P, Pineda-Alvarez DE, Zhou N, Jones M, Chandrasekharappa S, Richieri-Costa A, Muenke M.

Birth Defects Res A Clin Mol Teratol. 2012 Nov;94(11):912-7. doi: 10.1002/bdra.23047. Epub 2012 Jul 27.

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