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Items: 15


Targeting Tumor Metabolism for Cancer Treatment: Is Pyruvate Dehydrogenase Kinases (PDKs) a Viable Anticancer Target?

Zhang W, Zhang SL, Hu X, Tam KY.

Int J Biol Sci. 2015 Nov 1;11(12):1390-400. doi: 10.7150/ijbs.13325. eCollection 2015. Review.


Regulation of muscle pyruvate dehydrogenase complex in insulin resistance: effects of exercise and dichloroacetate.

Constantin-Teodosiu D.

Diabetes Metab J. 2013 Oct;37(5):301-14. doi: 10.4093/dmj.2013.37.5.301. Review.


Gene expression in skeletal muscle after an acute intravenous GH bolus in human subjects: identification of a mechanism regulating ANGPTL4.

Clasen BF, Krusenstjerna-Hafstrøm T, Vendelbo MH, Thorsen K, Escande C, Møller N, Pedersen SB, Jørgensen JO, Jessen N.

J Lipid Res. 2013 Jul;54(7):1988-97. doi: 10.1194/jlr.P034520. Epub 2013 Apr 20.


Erk regulation of pyruvate dehydrogenase flux through PDK4 modulates cell proliferation.

Grassian AR, Metallo CM, Coloff JL, Stephanopoulos G, Brugge JS.

Genes Dev. 2011 Aug 15;25(16):1716-33. doi: 10.1101/gad.16771811.


Histological and transcriptome-wide level characteristics of fetal myofiber hyperplasia during the second half of gestation in Texel and Ujumqin sheep.

Ren H, Li L, Su H, Xu L, Wei C, Zhang L, Li H, Liu W, Du L.

BMC Genomics. 2011 Aug 14;12:411. doi: 10.1186/1471-2164-12-411.


PPARδ activation acts cooperatively with 3-phosphoinositide-dependent protein kinase-1 to enhance mammary tumorigenesis.

Pollock CB, Yin Y, Yuan H, Zeng X, King S, Li X, Kopelovich L, Albanese C, Glazer RI.

PLoS One. 2011 Jan 13;6(1):e16215. doi: 10.1371/journal.pone.0016215.


Role of pyruvate dehydrogenase kinase 4 in regulation of blood glucose levels.

Jeoung NH, Harris RA.

Korean Diabetes J. 2010 Oct;34(5):274-83. doi: 10.4093/kdj.2010.34.5.274. Epub 2010 Oct 31.


Hypothalamic responses to fasting indicate metabolic reprogramming away from glycolysis toward lipid oxidation.

Poplawski MM, Mastaitis JW, Yang XJ, Mobbs CV.

Endocrinology. 2010 Nov;151(11):5206-17. doi: 10.1210/en.2010-0702. Epub 2010 Sep 29.


The Role of PPARα Activation in Liver and Muscle.

Burri L, Thoresen GH, Berge RK.

PPAR Res. 2010;2010. pii: 542359. doi: 10.1155/2010/542359. Epub 2010 Aug 18.


Muscle-derived angiopoietin-like protein 4 is induced by fatty acids via peroxisome proliferator-activated receptor (PPAR)-delta and is of metabolic relevance in humans.

Staiger H, Haas C, Machann J, Werner R, Weisser M, Schick F, Machicao F, Stefan N, Fritsche A, Häring HU.

Diabetes. 2009 Mar;58(3):579-89. doi: 10.2337/db07-1438. Epub 2008 Dec 15.


PPARdelta agonism inhibits skeletal muscle PDC activity, mitochondrial ATP production and force generation during prolonged contraction.

Constantin-Teodosiu D, Baker DJ, Constantin D, Greenhaff PL.

J Physiol. 2009 Jan 15;587(Pt 1):231-9. doi: 10.1113/jphysiol.2008.164210. Epub 2008 Nov 10.


PPARdelta agonism induces a change in fuel metabolism and activation of an atrophy programme, but does not impair mitochondrial function in rat skeletal muscle.

Constantin D, Constantin-Teodosiu D, Layfield R, Tsintzas K, Bennett AJ, Greenhaff PL.

J Physiol. 2007 Aug 15;583(Pt 1):381-90. Epub 2007 May 31.


Secrets of the lac operon. Glucose hysteresis as a mechanism in dietary restriction, aging and disease.

Mobbs CV, Mastaitis JW, Zhang M, Isoda F, Cheng H, Yen K.

Interdiscip Top Gerontol. 2007;35:39-68. Review.


PPAR delta: a dagger in the heart of the metabolic syndrome.

Barish GD, Narkar VA, Evans RM.

J Clin Invest. 2006 Mar;116(3):590-7. Review.

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