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Results: 1 to 20 of 32

Cited In for PubMed (Select 15953551)


Discovery and characterization of small molecules that target the GTPase Ral.

Yan C, Liu D, Li L, Wempe MF, Guin S, Khanna M, Meier J, Hoffman B, Owens C, Wysoczynski CL, Nitz MD, Knabe WE, Ahmed M, Brautigan DL, Paschal BM, Schwartz MA, Jones DN, Ross D, Meroueh SO, Theodorescu D.

Nature. 2014 Nov 20;515(7527):443-7. doi: 10.1038/nature13713. Epub 2014 Sep 14.


Exo70 isoform switching upon epithelial-mesenchymal transition mediates cancer cell invasion.

Lu H, Liu J, Liu S, Zeng J, Ding D, Carstens RP, Cong Y, Xu X, Guo W.

Dev Cell. 2013 Dec 9;27(5):560-73. doi: 10.1016/j.devcel.2013.10.020.


RalA promotes a direct exocyst-Par6 interaction to regulate polarity in neuronal development.

Das A, Gajendra S, Falenta K, Oudin MJ, Peschard P, Feng S, Wu B, Marshall CJ, Doherty P, Guo W, Lalli G.

J Cell Sci. 2014 Feb 1;127(Pt 3):686-99. doi: 10.1242/jcs.145037. Epub 2013 Nov 27.


RalA and RalB proteins are ubiquitinated GTPases, and ubiquitinated RalA increases lipid raft exposure at the plasma membrane.

Neyraud V, Aushev VN, Hatzoglou A, Meunier B, Cascone I, Camonis J.

J Biol Chem. 2012 Aug 24;287(35):29397-405. doi: 10.1074/jbc.M112.357764. Epub 2012 Jun 14.


A big new job for small GTPases.

Carmena A.

Small GTPases. 2012 Jul-Sep;3(3):159-62. doi: 10.4161/sgtp.19631. Epub 2012 May 31.


Overexpression of RalBP1 in colorectal cancer is an independent predictor of poor survival and early tumor relapse.

Mollberg NM, Steinert G, Aigner M, Hamm A, Lin FJ, Elbers H, Reissfelder C, Weitz J, Buchler MW, Koch M.

Cancer Biol Ther. 2012 Jun;13(8):694-700. doi: 10.4161/cbt.20087. Epub 2012 Jun 1.


Exorcising the exocyst complex.

Heider MR, Munson M.

Traffic. 2012 Jul;13(7):898-907. doi: 10.1111/j.1600-0854.2012.01353.x. Epub 2012 Apr 8. Review.


Exocyst subunits Exo70 and Exo84 cooperate with small GTPases to regulate behavior and endocytic trafficking in C. elegans.

Jiu Y, Jin C, Liu Y, Holmberg CI, Jäntti J.

PLoS One. 2012;7(2):e32077. doi: 10.1371/journal.pone.0032077. Epub 2012 Feb 28. Erratum in: PLoS One. 2012;7(6). doi:10.1371/annotation/5c145402-1089-4764-a204-e620e15b0e5b.


Polarity sets the stage for cytokinesis.

Hehnly H, Doxsey S.

Mol Biol Cell. 2012 Jan;23(1):7-11. doi: 10.1091/mbc.E11-06-0512.


RALA and RALBP1 regulate mitochondrial fission at mitosis.

Kashatus DF, Lim KH, Brady DC, Pershing NL, Cox AD, Counter CM.

Nat Cell Biol. 2011 Aug 7;13(9):1108-15. doi: 10.1038/ncb2310.


Different metastasis promotive potency of small G-proteins RalA and RalB in in vivo hamster tumor model.

Rybko VA, Knizhnik AV, Komelkov AV, Aushev VN, Trukhanova LS, Tchevkina EM.

Cancer Cell Int. 2011 Jun 29;11(1):22. doi: 10.1186/1475-2867-11-22.


The human Rgr oncogene is overexpressed in T-cell malignancies and induces transformation by acting as a GEF for Ras and Ral.

Osei-Sarfo K, Martello L, Ibrahim S, Pellicer A.

Oncogene. 2011 Aug 25;30(34):3661-71. doi: 10.1038/onc.2011.93. Epub 2011 Mar 28.


Direct binding of RalA to PKCη and its crucial role in morphological change during keratinocyte differentiation.

Shirai Y, Morioka S, Sakuma M, Yoshino K, Otsuji C, Sakai N, Kashiwagi K, Chida K, Shirakawa R, Horiuchi H, Nishigori C, Ueyama T, Saito N.

Mol Biol Cell. 2011 Apr 15;22(8):1340-52. doi: 10.1091/mbc.E10-09-0754. Epub 2011 Feb 23.


Emerging roles for the non-canonical IKKs in cancer.

Shen RR, Hahn WC.

Oncogene. 2011 Feb 10;30(6):631-41. doi: 10.1038/onc.2010.493. Epub 2010 Nov 1. Review.


Phosphorylation of RalB is important for bladder cancer cell growth and metastasis.

Wang H, Owens C, Chandra N, Conaway MR, Brautigan DL, Theodorescu D.

Cancer Res. 2010 Nov 1;70(21):8760-9. doi: 10.1158/0008-5472.CAN-10-0952. Epub 2010 Oct 12.


The Axl receptor tyrosine kinase is an adverse prognostic factor and a therapeutic target in esophageal adenocarcinoma.

Hector A, Montgomery EA, Karikari C, Canto M, Dunbar KB, Wang JS, Feldmann G, Hong SM, Haffner MC, Meeker AK, Holland SJ, Yu J, Heckrodt TJ, Zhang J, Ding P, Goff D, Singh R, Roa JC, Marimuthu A, Riggins GJ, Eshleman JR, Nelkin BD, Pandey A, Maitra A.

Cancer Biol Ther. 2010 Nov 15;10(10):1009-18. doi: 10.4161/cbt.10.10.13248. Epub 2010 Nov 15.


Ras-related small GTPases RalA and RalB regulate cellular survival after ionizing radiation.

Kidd AR 3rd, Snider JL, Martin TD, Graboski SF, Der CJ, Cox AD.

Int J Radiat Oncol Biol Phys. 2010 Sep 1;78(1):205-12. doi: 10.1016/j.ijrobp.2010.03.023. Epub 2010 Jul 7.


Genetic analysis of Ras signalling pathways in cell proliferation, migration and survival.

Drosten M, Dhawahir A, Sum EY, Urosevic J, Lechuga CG, Esteban LM, Castellano E, Guerra C, Santos E, Barbacid M.

EMBO J. 2010 Mar 17;29(6):1091-104. doi: 10.1038/emboj.2010.7. Epub 2010 Feb 11.


Sec5 and Exo84 foster oncogenic ras-mediated tumorigenesis.

Issaq SH, Lim KH, Counter CM.

Mol Cancer Res. 2010 Feb;8(2):223-31. doi: 10.1158/1541-7786.MCR-09-0189. Epub 2010 Feb 9.

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