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AMD and the alternative complement pathway: genetics and functional implications.

Tan PL, Bowes Rickman C, Katsanis N.

Hum Genomics. 2016 Jun 21;10(1):23. doi: 10.1186/s40246-016-0079-x. Review.


Analysis of Risk Alleles and Complement Activation Levels in Familial and Non-Familial Age-Related Macular Degeneration.

Saksens NT, Lechanteur YT, Verbakel SK, Groenewoud JM, Daha MR, Schick T, Fauser S, Boon CJ, Hoyng CB, den Hollander AI.

PLoS One. 2016 Jun 3;11(6):e0144367. doi: 10.1371/journal.pone.0144367. eCollection 2016.


A Novel Complotype Combination Associates with Age-Related Macular Degeneration and High Complement Activation Levels in vivo.

Paun CC, Lechanteur YT, Groenewoud JM, Altay L, Schick T, Daha MR, Fauser S, Hoyng CB, den Hollander AI, de Jong EK.

Sci Rep. 2016 May 31;6:26568. doi: 10.1038/srep26568.


Oxidative stress, innate immunity, and age-related macular degeneration.

Shaw PX, Stiles T, Douglas C, Ho D, Fan W, Du H, Xiao X.

AIMS Mol Sci. 2016;3(2):196-221. Epub 2016 May 11.


Retinal Remodeling and Metabolic Alterations in Human AMD.

Jones BW, Pfeiffer RL, Ferrell WD, Watt CB, Tucker J, Marc RE.

Front Cell Neurosci. 2016 Apr 28;10:103. doi: 10.3389/fncel.2016.00103. eCollection 2016.


Genetic Association Analysis of Drusen Progression.

Hoffman JD, van Grinsven MJ, Li C, Brantley M Jr, McGrath J, Agarwal A, Scott WK, Schwartz SG, Kovach J, Pericak-Vance M, Sanchez CI, Haines JL.

Invest Ophthalmol Vis Sci. 2016 Apr 1;57(4):2225-31. doi: 10.1167/iovs.15-18571.


Multiallelic copy number variation in the complement component 4A (C4A) gene is associated with late-stage age-related macular degeneration (AMD).

Grassmann F, Cantsilieris S, Schulz-Kuhnt AS, White SJ, Richardson AJ, Hewitt AW, Vote BJ, Schmied D, Guymer RH, Weber BH, Baird PN.

J Neuroinflammation. 2016 Apr 18;13(1):81. doi: 10.1186/s12974-016-0548-0.


Connecting the innate and adaptive immune responses in mouse choroidal neovascularization via the anaphylatoxin C5a and γδT-cells.

Coughlin B, Schnabolk G, Joseph K, Raikwar H, Kunchithapautham K, Johnson K, Moore K, Wang Y, Rohrer B.

Sci Rep. 2016 Mar 31;6:23794. doi: 10.1038/srep23794.


Regulation of signaling events involved in the pathophysiology of neovascular AMD.

Wang H, Hartnett ME.

Mol Vis. 2016 Feb 27;22:189-202. eCollection 2016. Review.



Wang X, Pan W, Hu W, Tian Y, Zhang H.

J Am Stat Assoc. 2015;110(512):1726-1734. Epub 2015 Jan 23.


Inflammation and its role in age-related macular degeneration.

Kauppinen A, Paterno JJ, Blasiak J, Salminen A, Kaarniranta K.

Cell Mol Life Sci. 2016 May;73(9):1765-86. doi: 10.1007/s00018-016-2147-8. Epub 2016 Feb 6. Review.


Fucoidan as a Potential Therapeutic for Major Blinding Diseases--A Hypothesis.

Klettner A.

Mar Drugs. 2016 Feb 3;14(2). pii: E31. doi: 10.3390/md14020031. Review.


Factor H uptake regulates intracellular C3 activation during apoptosis and decreases the inflammatory potential of nucleosomes.

Martin M, Leffler J, Smoląg KI, Mytych J, Björk A, Chaves LD, Alexander JJ, Quigg RJ, Blom AM.

Cell Death Differ. 2016 May;23(5):903-11. doi: 10.1038/cdd.2015.164. Epub 2016 Jan 15.


Annexin A2 Enhances Complement Activation by Inhibiting Factor H.

Renner B, Tong HH, Laskowski J, Jonscher K, Goetz L, Woolaver R, Hannan J, Li YX, Hourcade D, Pickering MC, Holers VM, Thurman JM.

J Immunol. 2016 Feb 1;196(3):1355-65. doi: 10.4049/jimmunol.1500793. Epub 2016 Jan 4.


Circulating Autoantibodies in Age-Related Macular Degeneration Recognize Human Macular Tissue Antigens Implicated in Autophagy, Immunomodulation, and Protection from Oxidative Stress and Apoptosis.

Iannaccone A, Giorgianni F, New DD, Hollingsworth TJ, Umfress A, Alhatem AH, Neeli I, Lenchik NI, Jennings BJ, Calzada JI, Satterfield S, Mathews D, Diaz RI, Harris T, Johnson KC, Charles S, Kritchevsky SB, Gerling IC, Beranova-Giorgianni S, Radic MZ; Health ABC study.

PLoS One. 2015 Dec 30;10(12):e0145323. doi: 10.1371/journal.pone.0145323. eCollection 2015.


PBN (Phenyl-N-Tert-Butylnitrone)-Derivatives Are Effective in Slowing the Visual Cycle and Rhodopsin Regeneration and in Protecting the Retina from Light-Induced Damage.

Stiles M, Moiseyev GP, Budda ML, Linens A, Brush RS, Qi H, White GL, Wolf RF, Ma JX, Floyd R, Anderson RE, Mandal NA.

PLoS One. 2015 Dec 22;10(12):e0145305. doi: 10.1371/journal.pone.0145305. eCollection 2015.


Anti-complement activity of the Ixodes scapularis salivary protein Salp20.

Hourcade DE, Akk AM, Mitchell LM, Zhou HF, Hauhart R, Pham CT.

Mol Immunol. 2016 Jan;69:62-9. doi: 10.1016/j.molimm.2015.11.008. Epub 2015 Dec 8.


Combination of Aflibercept and Bromfenac Therapy in Age-Related Macular Degeneration: A Pilot Study Aflibercept and Bromfenac in AMD.

Wyględowska-Promieńska D, Piotrowska-Gwóźdź A, Piotrowska-Seweryn A, Mazur-Piotrowska G.

Med Sci Monit. 2015 Dec 15;21:3906-12.


Enrichment of Bruch's Membrane from Human Donor Eyes.

McHarg S, Brace N, Bishop PN, Clark SJ.

J Vis Exp. 2015 Nov 15;(105). doi: 10.3791/53382.

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