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Promiscuity in the Enzymatic Catalysis of Phosphate and Sulfate Transfer.

Pabis A, Duarte F, Kamerlin SC.

Biochemistry. 2016 Jun 7;55(22):3061-81. doi: 10.1021/acs.biochem.6b00297. Epub 2016 May 26.


Functional Characterization of a Novel Member of the Amidohydrolase 2 Protein Family, 2-Hydroxy-1-Naphthoic Acid Nonoxidative Decarboxylase from Burkholderia sp. Strain BC1.

Pal Chowdhury P, Basu S, Dutta A, Dutta TK.

J Bacteriol. 2016 May 27;198(12):1755-63. doi: 10.1128/JB.00250-16. Print 2016 Jun 15.


Substrate Distortion and the Catalytic Reaction Mechanism of 5-Carboxyvanillate Decarboxylase.

Vladimirova A, Patskovsky Y, Fedorov AA, Bonanno JB, Fedorov EV, Toro R, Hillerich B, Seidel RD, Richards NG, Almo SC, Raushel FM.

J Am Chem Soc. 2016 Jan 27;138(3):826-36. doi: 10.1021/jacs.5b08251. Epub 2016 Jan 12.


X-Ray Structure and Mutagenesis Studies of the N-Isopropylammelide Isopropylaminohydrolase, AtzC.

Balotra S, Warden AC, Newman J, Briggs LJ, Scott C, Peat TS.

PLoS One. 2015 Sep 21;10(9):e0137700. doi: 10.1371/journal.pone.0137700. eCollection 2015.


Inhibition of a Putative Dihydropyrimidinase from Pseudomonas aeruginosa PAO1 by Flavonoids and Substrates of Cyclic Amidohydrolases.

Huang CY.

PLoS One. 2015 May 19;10(5):e0127634. doi: 10.1371/journal.pone.0127634. eCollection 2015.


Structure-guided engineering of molinate hydrolase for the degradation of thiocarbamate pesticides.

Leite JP, Duarte M, Paiva AM, Ferreira-da-Silva F, Matias PM, Nunes OC, Gales L.

PLoS One. 2015 Apr 23;10(4):e0123430. doi: 10.1371/journal.pone.0123430. eCollection 2015.


Function discovery and structural characterization of a methylphosphonate esterase.

Xiang DF, Patskovsky Y, Nemmara VV, Toro R, Almo SC, Raushel FM.

Biochemistry. 2015 May 12;54(18):2919-30. doi: 10.1021/acs.biochem.5b00199. Epub 2015 Apr 28.


The structure of the hexameric atrazine chlorohydrolase AtzA.

Peat TS, Newman J, Balotra S, Lucent D, Warden AC, Scott C.

Acta Crystallogr D Biol Crystallogr. 2015 Mar;71(Pt 3):710-20. doi: 10.1107/S1399004715000619. Epub 2015 Feb 26.


Active site loop conformation regulates promiscuous activity in a lactonase from Geobacillus kaustophilus HTA426.

Zhang Y, An J, Yang GY, Bai A, Zheng B, Lou Z, Wu G, Ye W, Chen HF, Feng Y, Manco G.

PLoS One. 2015 Feb 23;10(2):e0115130. doi: 10.1371/journal.pone.0115130. eCollection 2015.


Crystal structure of VmoLac, a tentative quorum quenching lactonase from the extremophilic crenarchaeon Vulcanisaeta moutnovskia.

Hiblot J, Bzdrenga J, Champion C, Chabriere E, Elias M.

Sci Rep. 2015 Feb 11;5:8372. doi: 10.1038/srep08372.


Expanding the enzyme universe: accessing non-natural reactions by mechanism-guided directed evolution.

Renata H, Wang ZJ, Arnold FH.

Angew Chem Int Ed Engl. 2015 Mar 9;54(11):3351-67. doi: 10.1002/anie.201409470. Epub 2015 Feb 3. Review.


Evolutionary expansion of the amidohydrolase superfamily in bacteria in response to the synthetic compounds molinate and diuron.

Sugrue E, Fraser NJ, Hopkins DH, Carr PD, Khurana JL, Oakeshott JG, Scott C, Jackson CJ.

Appl Environ Microbiol. 2015 Apr;81(7):2612-24. doi: 10.1128/AEM.04016-14. Epub 2015 Jan 30.


An evolutionary biochemist's perspective on promiscuity.

Copley SD.

Trends Biochem Sci. 2015 Feb;40(2):72-8. doi: 10.1016/j.tibs.2014.12.004. Epub 2015 Jan 5.


Structure of N-formimino-L-glutamate iminohydrolase from Pseudomonas aeruginosa.

Fedorov AA, Martí-Arbona R, Nemmara VV, Hitchcock D, Fedorov EV, Almo SC, Raushel FM.

Biochemistry. 2015 Jan 27;54(3):890-7. doi: 10.1021/bi501299y. Epub 2015 Jan 16.


Discovery of a bacterial 5-methylcytosine deaminase.

Hitchcock DS, Fedorov AA, Fedorov EV, Almo SC, Raushel FM.

Biochemistry. 2014 Dec 2;53(47):7426-35. doi: 10.1021/bi5012767. Epub 2014 Nov 19.


Characterization of p-hydroxycinnamate catabolism in a soil Actinobacterium.

Otani H, Lee YE, Casabon I, Eltis LD.

J Bacteriol. 2014 Dec;196(24):4293-303. doi: 10.1128/JB.02247-14. Epub 2014 Sep 29.


Discovery of a novel iota carrageenan sulfatase isolated from the marine bacterium Pseudoalteromonas carrageenovora.

Genicot SM, Groisillier A, Rogniaux H, Meslet-Cladière L, Barbeyron T, Helbert W.

Front Chem. 2014 Aug 26;2:67. doi: 10.3389/fchem.2014.00067. eCollection 2014.


l-Galactose metabolism in Bacteroides vulgatus from the human gut microbiota.

Hobbs ME, Williams HJ, Hillerich B, Almo SC, Raushel FM.

Biochemistry. 2014 Jul 22;53(28):4661-70. doi: 10.1021/bi500656m. Epub 2014 Jul 7.


Functional annotation and structural characterization of a novel lactonase hydrolyzing D-xylono-1,4-lactone-5-phosphate and L-arabino-1,4-lactone-5-phosphate.

Korczynska M, Xiang DF, Zhang Z, Xu C, Narindoshvili T, Kamat SS, Williams HJ, Chang SS, Kolb P, Hillerich B, Sauder JM, Burley SK, Almo SC, Swaminathan S, Shoichet BK, Raushel FM.

Biochemistry. 2014 Jul 22;53(28):4727-38. doi: 10.1021/bi500595c. Epub 2014 Jul 9.


Structures of bacterial kynurenine formamidase reveal a crowded binuclear zinc catalytic site primed to generate a potent nucleophile.

Díaz-Sáez L, Srikannathasan V, Zoltner M, Hunter WN.

Biochem J. 2014 Sep 15;462(3):581-9. doi: 10.1042/BJ20140511.

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