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Items: 1 to 20 of 58

1.

Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity.

Cole DK, Bulek AM, Dolton G, Schauenberg AJ, Szomolay B, Rittase W, Trimby A, Jothikumar P, Fuller A, Skowera A, Rossjohn J, Zhu C, Miles JJ, Peakman M, Wooldridge L, Rizkallah PJ, Sewell AK.

J Clin Invest. 2016 Jun 1;126(6):2191-204. doi: 10.1172/JCI85679. Epub 2016 May 16.

PMID:
27183389
2.

Identifying Individual T Cell Receptors of Optimal Avidity for Tumor Antigens.

Hebeisen M, Allard M, Gannon PO, Schmidt J, Speiser DE, Rufer N.

Front Immunol. 2015 Nov 18;6:582. doi: 10.3389/fimmu.2015.00582. eCollection 2015. Review.

3.

Enhanced Detection of Antigen-Specific CD4+ T Cells Using Altered Peptide Flanking Residue Peptide-MHC Class II Multimers.

Holland CJ, Dolton G, Scurr M, Ladell K, Schauenburg AJ, Miners K, Madura F, Sewell AK, Price DA, Cole DK, Godkin AJ.

J Immunol. 2015 Dec 15;195(12):5827-36. doi: 10.4049/jimmunol.1402787. Epub 2015 Nov 9.

4.

Lower Affinity T Cells are Critical Components and Active Participants of the Immune Response.

Martinez RJ, Evavold BD.

Front Immunol. 2015 Sep 10;6:468. doi: 10.3389/fimmu.2015.00468. eCollection 2015. Review.

5.

Expansion of Simian Immunodeficiency Virus (SIV)-Specific CD8 T Cell Lines from SIV-Naive Mauritian Cynomolgus Macaques for Adoptive Transfer.

Mohns MS, Greene JM, Cain BT, Pham NH, Gostick E, Price DA, O'Connor DH.

J Virol. 2015 Oct;89(19):9748-57. doi: 10.1128/JVI.00993-15. Epub 2015 Jul 15.

6.

Distortion of the Major Histocompatibility Complex Class I Binding Groove to Accommodate an Insulin-derived 10-Mer Peptide.

Motozono C, Pearson JA, De Leenheer E, Rizkallah PJ, Beck K, Trimby A, Sewell AK, Wong FS, Cole DK.

J Biol Chem. 2015 Jul 31;290(31):18924-33. doi: 10.1074/jbc.M114.622522. Epub 2015 Jun 17.

7.

More tricks with tetramers: a practical guide to staining T cells with peptide-MHC multimers.

Dolton G, Tungatt K, Lloyd A, Bianchi V, Theaker SM, Trimby A, Holland CJ, Donia M, Godkin AJ, Cole DK, Straten PT, Peakman M, Svane IM, Sewell AK.

Immunology. 2015 Sep;146(1):11-22. doi: 10.1111/imm.12499. Review.

PMID:
26076649
8.

Introduction of a point mutation into an HLA class I single-chain trimer induces enhancement of CTL priming and antitumor immunity.

Matsui M, Kawano M, Matsushita S, Akatsuka T.

Mol Ther Methods Clin Dev. 2014 Jul 2;1:14027. doi: 10.1038/mtm.2014.27. eCollection 2014.

9.

The promise of γδ T cells and the γδ T cell receptor for cancer immunotherapy.

Legut M, Cole DK, Sewell AK.

Cell Mol Immunol. 2015 Nov;12(6):656-68. doi: 10.1038/cmi.2015.28. Epub 2015 Apr 13. Review.

10.

Phage Display Engineered T Cell Receptors as Tools for the Study of Tumor Peptide-MHC Interactions.

Løset GÅ, Berntzen G, Frigstad T, Pollmann S, Gunnarsen KS, Sandlie I.

Front Oncol. 2015 Jan 12;4:378. doi: 10.3389/fonc.2014.00378. eCollection 2014. Review.

11.

T cell receptor binding affinity governs the functional profile of cancer-specific CD8+ T cells.

Tan MP, Gerry AB, Brewer JE, Melchiori L, Bridgeman JS, Bennett AD, Pumphrey NJ, Jakobsen BK, Price DA, Ladell K, Sewell AK.

Clin Exp Immunol. 2015 May;180(2):255-70. doi: 10.1111/cei.12570.

12.

Antibody stabilization of peptide-MHC multimers reveals functional T cells bearing extremely low-affinity TCRs.

Tungatt K, Bianchi V, Crowther MD, Powell WE, Schauenburg AJ, Trimby A, Donia M, Miles JJ, Holland CJ, Cole DK, Godkin AJ, Peakman M, Straten PT, Svane IM, Sewell AK, Dolton G.

J Immunol. 2015 Jan 1;194(1):463-74. doi: 10.4049/jimmunol.1401785. Epub 2014 Dec 1.

13.

Ligand-engaged TCR is triggered by Lck not associated with CD8 coreceptor.

Casas J, Brzostek J, Zarnitsyna VI, Hong JS, Wei Q, Hoerter JA, Fu G, Ampudia J, Zamoyska R, Zhu C, Gascoigne NR.

Nat Commun. 2014 Nov 27;5:5624. doi: 10.1038/ncomms6624.

14.

Comparison of peptide-major histocompatibility complex tetramers and dextramers for the identification of antigen-specific T cells.

Dolton G, Lissina A, Skowera A, Ladell K, Tungatt K, Jones E, Kronenberg-Versteeg D, Akpovwa H, Pentier JM, Holland CJ, Godkin AJ, Cole DK, Neller MA, Miles JJ, Price DA, Peakman M, Sewell AK.

Clin Exp Immunol. 2014 Jul;177(1):47-63. doi: 10.1111/cei.12339.

15.

Proximity of TCR and its CD8 coreceptor controls sensitivity of T cells.

Borger JG, Zamoyska R, Gakamsky DM.

Immunol Lett. 2014 Jan-Feb;157(1-2):16-22. doi: 10.1016/j.imlet.2013.11.005. Epub 2013 Nov 18.

16.

Co-Receptor CD8-Mediated Modulation of T-Cell Receptor Functional Sensitivity and Epitope Recognition Degeneracy.

Szomolay B, Williams T, Wooldridge L, van den Berg HA.

Front Immunol. 2013 Oct 21;4:329. doi: 10.3389/fimmu.2013.00329. Review. Erratum in: Front Immunol. 2014;5:443.

17.

2D TCR-pMHC-CD8 kinetics determines T-cell responses in a self-antigen-specific TCR system.

Liu B, Zhong S, Malecek K, Johnson LA, Rosenberg SA, Zhu C, Krogsgaard M.

Eur J Immunol. 2014 Jan;44(1):239-50. doi: 10.1002/eji.201343774. Epub 2013 Oct 20.

18.

Cellular-level versus receptor-level response threshold hierarchies in T-cell activation.

van den Berg HA, Ladell K, Miners K, Laugel B, Llewellyn-Lacey S, Clement M, Cole DK, Gostick E, Wooldridge L, Sewell AK, Bridgeman JS, Price DA.

Front Immunol. 2013 Sep 5;4:250. doi: 10.3389/fimmu.2013.00250. eCollection 2013.

19.

CD8αα Expression Marks Terminally Differentiated Human CD8+ T Cells Expanded in Chronic Viral Infection.

Walker LJ, Marrinan E, Muenchhoff M, Ferguson J, Kloverpris H, Cheroutre H, Barnes E, Goulder P, Klenerman P.

Front Immunol. 2013 Aug 6;4:223. doi: 10.3389/fimmu.2013.00223. eCollection 2013.

20.

Age-associated increase of low-avidity cytomegalovirus-specific CD8+ T cells that re-express CD45RA.

Griffiths SJ, Riddell NE, Masters J, Libri V, Henson SM, Wertheimer A, Wallace D, Sims S, Rivino L, Larbi A, Kemeny DM, Nikolich-Zugich J, Kern F, Klenerman P, Emery VC, Akbar AN.

J Immunol. 2013 Jun 1;190(11):5363-72. doi: 10.4049/jimmunol.1203267. Epub 2013 May 1.

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