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New perspectives on exploitation of incretin peptides for the treatment of diabetes and related disorders.

Irwin N, Flatt PR.

World J Diabetes. 2015 Nov 10;6(15):1285-95. doi: 10.4239/wjd.v6.i15.1285. Review.


Effects of High Glucose Levels and Glycated Serum on GIP Responsiveness in the Pancreatic Beta Cell Line HIT-T15.

Puddu A, Sanguineti R, Montecucco F, Viviani GL.

J Diabetes Res. 2015;2015:326359. doi: 10.1155/2015/326359. Epub 2015 Jun 29.


Liraglutide protects pancreatic β-cells against free fatty acids in vitro and affects glucolipid metabolism in apolipoprotein E-/- mice by activating autophagy.

Wang J, Wu J, Wu H, Liu X, Chen Y, Wu J, Hu C, Zou D.

Mol Med Rep. 2015 Sep;12(3):4210-8. doi: 10.3892/mmr.2015.3944. Epub 2015 Jun 16.


Glucolipotoxicity impairs ceramide flow from the endoplasmic reticulum to the Golgi apparatus in INS-1 β-cells.

Gjoni E, Brioschi L, Cinque A, Coant N, Islam MN, Ng CK, Verderio C, Magnan C, Riboni L, Viani P, Le Stunff H, Giussani P.

PLoS One. 2014 Oct 28;9(10):e110875. doi: 10.1371/journal.pone.0110875. eCollection 2014.


Lithium ameliorates lipopolysaccharide-induced microglial activation via inhibition of toll-like receptor 4 expression by activating the PI3K/Akt/FoxO1 pathway.

Dong H, Zhang X, Dai X, Lu S, Gui B, Jin W, Zhang S, Zhang S, Qian Y.

J Neuroinflammation. 2014 Aug 14;11:140. doi: 10.1186/s12974-014-0140-4.


Potential roles of GPR120 and its agonists in the management of diabetes.

Zhang D, Leung PS.

Drug Des Devel Ther. 2014 Jul 29;8:1013-27. doi: 10.2147/DDDT.S53892. eCollection 2014. Review.


Glucose-dependent insulinotropic polypeptide signaling in pancreatic β-cells and adipocytes.

McIntosh CH, Widenmaier S, Kim SJ.

J Diabetes Investig. 2012 Mar 28;3(2):96-106. doi: 10.1111/j.2040-1124.2012.00196.x. Review.


GIP and GLP-1, the two incretin hormones: Similarities and differences.

Seino Y, Fukushima M, Yabe D.

J Diabetes Investig. 2010 Apr 22;1(1-2):8-23. doi: 10.1111/j.2040-1124.2010.00022.x. Review.


Sitagliptin prevents inflammation and apoptotic cell death in the kidney of type 2 diabetic animals.

Marques C, Mega C, Gonçalves A, Rodrigues-Santos P, Teixeira-Lemos E, Teixeira F, Fontes-Ribeiro C, Reis F, Fernandes R.

Mediators Inflamm. 2014;2014:538737. doi: 10.1155/2014/538737. Epub 2014 Apr 8.


Transcriptional analysis of apoptotic cerebellar granule neurons following rescue by gastric inhibitory polypeptide.

Maino B, Ciotti MT, Calissano P, Cavallaro S.

Int J Mol Sci. 2014 Apr 1;15(4):5596-622. doi: 10.3390/ijms15045596.


The antiapoptotic function of miR-96 in prostate cancer by inhibition of FOXO1.

Fendler A, Jung M, Stephan C, Erbersdobler A, Jung K, Yousef GM.

PLoS One. 2013 Nov 19;8(11):e80807. doi: 10.1371/journal.pone.0080807. eCollection 2013.


Recent advances in understanding the anti-diabetic actions of dietary flavonoids.

Babu PV, Liu D, Gilbert ER.

J Nutr Biochem. 2013 Nov;24(11):1777-89. doi: 10.1016/j.jnutbio.2013.06.003. Epub 2013 Sep 9. Review.


Peroxisome proliferator-activated receptor γ (PPARγ) and its target genes are downstream effectors of FoxO1 protein in islet β-cells: mechanism of β-cell compensation and failure.

Gupta D, Leahy AA, Monga N, Peshavaria M, Jetton TL, Leahy JL.

J Biol Chem. 2013 Aug 30;288(35):25440-9. doi: 10.1074/jbc.M113.486852. Epub 2013 Jun 20.


Signaling molecules involved in lipid-induced pancreatic beta-cell dysfunction.

Shao S, Yang Y, Yuan G, Zhang M, Yu X.

DNA Cell Biol. 2013 Feb;32(2):41-9. doi: 10.1089/dna.2012.1874. Review.


Cocaine- and amphetamine-regulated transcript (CART) protects beta cells against glucotoxicity and increases cell proliferation.

Sathanoori R, Olde B, Erlinge D, Göransson O, Wierup N.

J Biol Chem. 2013 Feb 1;288(5):3208-18. doi: 10.1074/jbc.M112.437145. Epub 2012 Dec 16.


Review article: the emerging interplay among the gastrointestinal tract, bile acids and incretins in the pathogenesis of diabetes and non-alcoholic fatty liver disease.

Zarrinpar A, Loomba R.

Aliment Pharmacol Ther. 2012 Nov;36(10):909-21. doi: 10.1111/apt.12084. Epub 2012 Oct 11. Review.


Islet β-Cell Mass Preservation and Regeneration in Diabetes Mellitus: Four Factors with Potential Therapeutic Interest.

Mellado-Gil JM, Cobo-Vuilleumier N, Gauthier BR.

J Transplant. 2012;2012:230870. doi: 10.1155/2012/230870. Epub 2012 Aug 5.


Nutrient detection by incretin hormone secreting cells.

Diakogiannaki E, Gribble FM, Reimann F.

Physiol Behav. 2012 Jun 6;106(3):387-93. doi: 10.1016/j.physbeh.2011.12.001. Epub 2011 Dec 13. Review.


Glucose-dependent insulinotropic polypeptide reduces fat-specific expression and activity of 11β-hydroxysteroid dehydrogenase type 1 and inhibits release of free fatty acids.

Gögebakan Ö, Andres J, Biedasek K, Mai K, Kühnen P, Krude H, Isken F, Rudovich N, Osterhoff MA, Kintscher U, Nauck M, Pfeiffer AF, Spranger J.

Diabetes. 2012 Feb;61(2):292-300. doi: 10.2337/db10-0902. Epub 2011 Dec 16.


Glucagon-like peptide 1 inhibits the sirtuin deacetylase SirT1 to stimulate pancreatic β-cell mass expansion.

Bastien-Dionne PO, Valenti L, Kon N, Gu W, Buteau J.

Diabetes. 2011 Dec;60(12):3217-22. doi: 10.2337/db11-0101. Epub 2011 Oct 19.

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