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Items: 1 to 20 of 35


Hyperglycemia and hyperlipidemia blunts the Insulin-Inpp5f negative feedback loop in the diabetic heart.

Bai D, Zhang Y, Shen M, Sun Y, Xia Q, Zhang Y, Liu X, Wang H, Yuan L.

Sci Rep. 2016 Feb 24;6:22068. doi: 10.1038/srep22068.


Effect of Diazoxide Preconditioning on Cultured Rat Myocardium Microvascular Endothelial Cells against Apoptosis and Relation of PI3K/Akt Pathway.

Su C, Xia T, Ren S, Qing S, Jing D, Lian H, Bin Q, Yuan Z, Xiang Z.

Balkan Med J. 2014 Mar;31(1):83-7. doi: 10.5152/balkanmedj.2013.8458. Epub 2014 Mar 1.


The dipeptidyl peptidase-4 inhibitor sitagliptin protects against dyslipidemia-related kidney injury in Apolipoprotein E knockout mice.

Li J, Guan M, Li C, Lyv F, Zeng Y, Zheng Z, Wang C, Xue Y.

Int J Mol Sci. 2014 Jun 26;15(7):11416-34. doi: 10.3390/ijms150711416.


Knockdown of AKT3 (PKBγ) and PI3KCA suppresses cell viability and proliferation and induces the apoptosis of glioblastoma multiforme T98G cells.

Paul-Samojedny M, Suchanek R, Borkowska P, Pudełko A, Owczarek A, Kowalczyk M, Machnik G, Fila-Daniłow A, Kowalski J.

Biomed Res Int. 2014;2014:768181. doi: 10.1155/2014/768181. Epub 2014 May 22.


Resveratrol Prevention of Diabetic Nephropathy Is Associated with the Suppression of Renal Inflammation and Mesangial Cell Proliferation: Possible Roles of Akt/NF-κB Pathway.

Xu F, Wang Y, Cui W, Yuan H, Sun J, Wu M, Guo Q, Kong L, Wu H, Miao L.

Int J Endocrinol. 2014;2014:289327. doi: 10.1155/2014/289327. Epub 2014 Feb 9.


Cancer cachexia--pathophysiology and management.

Suzuki H, Asakawa A, Amitani H, Nakamura N, Inui A.

J Gastroenterol. 2013 May;48(5):574-94. doi: 10.1007/s00535-013-0787-0. Epub 2013 Mar 20. Review.


Regulation of molecular chaperones through post-translational modifications: decrypting the chaperone code.

Cloutier P, Coulombe B.

Biochim Biophys Acta. 2013 May;1829(5):443-54. doi: 10.1016/j.bbagrm.2013.02.010. Epub 2013 Feb 28. Review.


Substrate recognition of PLCγ1 via a specific docking surface on Itk.

Xie Q, Joseph RE, Fulton DB, Andreotti AH.

J Mol Biol. 2013 Feb 22;425(4):683-96. doi: 10.1016/j.jmb.2012.10.023. Epub 2012 Dec 3.


Phosphatidylinositol 3-kinase/Akt signaling pathway activates the WNK-OSR1/SPAK-NCC phosphorylation cascade in hyperinsulinemic db/db mice.

Nishida H, Sohara E, Nomura N, Chiga M, Alessi DR, Rai T, Sasaki S, Uchida S.

Hypertension. 2012 Oct;60(4):981-90. doi: 10.1161/HYPERTENSIONAHA.112.201509. Epub 2012 Sep 4.


Enhanced phosphorylation of Na(+)-Cl- co-transporter in experimental metabolic syndrome: role of insulin.

Komers R, Rogers S, Oyama TT, Xu B, Yang CL, McCormick J, Ellison DH.

Clin Sci (Lond). 2012 Dec;123(11):635-47. doi: 10.1042/CS20120003.


Insulin resistance in the nervous system.

Kim B, Feldman EL.

Trends Endocrinol Metab. 2012 Mar;23(3):133-41. doi: 10.1016/j.tem.2011.12.004. Epub 2012 Jan 13. Review.


The role of myostatin in muscle wasting: an overview.

Elkina Y, von Haehling S, Anker SD, Springer J.

J Cachexia Sarcopenia Muscle. 2011 Sep;2(3):143-151. Epub 2011 Jul 26.


Taurine reduces nitrosative stress and nitric oxide synthase expression in high glucose-exposed human Schwann cells.

Askwith T, Zeng W, Eggo MC, Stevens MJ.

Exp Neurol. 2012 Jan;233(1):154-62. doi: 10.1016/j.expneurol.2011.09.010. Epub 2011 Sep 17.


Norovirus RNA-dependent RNA polymerase is phosphorylated by an important survival kinase, Akt.

Eden JS, Sharpe LJ, White PA, Brown AJ.

J Virol. 2011 Oct;85(20):10894-8. doi: 10.1128/JVI.05562-11. Epub 2011 Aug 17.


Inhibition of Akt with small molecules and biologics: historical perspective and current status of the patent landscape.

Mattmann ME, Stoops SL, Lindsley CW.

Expert Opin Ther Pat. 2011 Sep;21(9):1309-38. doi: 10.1517/13543776.2011.587959. Epub 2011 Jun 2. Review.


Chiral kinase inhibitors.

Jiang JK, Shen M, Thomas CJ, Boxer MB.

Curr Top Med Chem. 2011;11(7):800-9. Review.


Characterization of the ZBTB42 gene in humans and mice.

Devaney SA, Mate SE, Devaney JM, Hoffman EP.

Hum Genet. 2011 Apr;129(4):433-41. doi: 10.1007/s00439-010-0940-2. Epub 2010 Dec 31.


AKT1 polymorphisms are associated with risk for metabolic syndrome.

Devaney JM, Gordish-Dressman H, Harmon BT, Bradbury MK, Devaney SA, Harris TB, Thompson PD, Clarkson PM, Price TB, Angelopoulos TJ, Gordon PM, Moyna NM, Pesca LS, VIsich PS, Zoeller RF, Seip RL, Seo J, Kim BH, Tosi LL, Garcia M, Li R, Zmuda J, Delmonico MJ, Lindsay RS, Howard BV, Kraus WE, Hoffman EP.

Hum Genet. 2011 Feb;129(2):129-39. doi: 10.1007/s00439-010-0910-8.

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