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Results: 1 to 20 of 35

1.

RasGRP3 limits Toll-like receptor-triggered inflammatory response in macrophages by activating Rap1 small GTPase.

Tang S, Chen T, Yu Z, Zhu X, Yang M, Xie B, Li N, Cao X, Wang J.

Nat Commun. 2014 Aug 14;5:4657. doi: 10.1038/ncomms5657.

PMID:
25118589
[PubMed - in process]
Free PMC Article
2.

Function of RasGRP3 in the formation and progression of human breast cancer.

Nagy Z, Kovács I, Török M, Tóth D, Vereb G, Buzás K, Juhász I, Blumberg PM, Bíró T, Czifra G.

Mol Cancer. 2014 Apr 29;13:96. doi: 10.1186/1476-4598-13-96.

PMID:
24779681
[PubMed - in process]
Free PMC Article
3.

RasGRP Ras guanine nucleotide exchange factors in cancer.

Ksionda O, Limnander A, Roose JP.

Front Biol (Beijing). 2013 Oct 1;8(5):508-532.

PMID:
24744772
[PubMed]
Free PMC Article
4.

Upregulation of RASGRP3 expression in prostate cancer correlates with aggressive capabilities and predicts biochemical recurrence after radical prostatectomy.

Zeng X, Hu Z, Wang Z, Tao J, Lu T, Yang C, Lee B, Ye Z.

Prostate Cancer Prostatic Dis. 2014 Jun;17(2):119-25. doi: 10.1038/pcan.2013.51. Epub 2014 Jan 14.

PMID:
24418912
[PubMed - in process]
Free PMC Article
5.

Rasgrp1 mutation increases naive T-cell CD44 expression and drives mTOR-dependent accumulation of Helios⁺ T cells and autoantibodies.

Daley SR, Coakley KM, Hu DY, Randall KL, Jenne CN, Limnander A, Myers DR, Polakos NK, Enders A, Roots C, Balakishnan B, Miosge LA, Sjollema G, Bertram EM, Field MA, Shao Y, Andrews TD, Whittle B, Barnes SW, Walker JR, Cyster JG, Goodnow CC, Roose JP.

Elife. 2013 Dec 12;2:e01020. doi: 10.7554/eLife.01020.

PMID:
24336796
[PubMed - in process]
Free PMC Article
6.

Regulation of ras exchange factors and cellular localization of ras activation by lipid messengers in T cells.

Jun JE, Rubio I, Roose JP.

Front Immunol. 2013 Sep 4;4:239. doi: 10.3389/fimmu.2013.00239. Review.

PMID:
24027568
[PubMed]
Free PMC Article
7.

RasGRPs are targets of the anti-cancer agent ingenol-3-angelate.

Song X, Lopez-Campistrous A, Sun L, Dower NA, Kedei N, Yang J, Kelsey JS, Lewin NE, Esch TE, Blumberg PM, Stone JC.

PLoS One. 2013 Aug 21;8(8):e72331. doi: 10.1371/journal.pone.0072331. eCollection 2013.

PMID:
23991094
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

More paths to PI3Kγ.

Stephens L, Hawkins P.

PLoS Biol. 2013;11(6):e1001594. doi: 10.1371/journal.pbio.1001594. Epub 2013 Jun 25. Review. No abstract available.

PMID:
23853549
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Phosphorylation of serine 779 in fibroblast growth factor receptor 1 and 2 by protein kinase C(epsilon) regulates Ras/mitogen-activated protein kinase signaling and neuronal differentiation.

Lonic A, Powell JA, Kong Y, Thomas D, Holien JK, Truong N, Parker MW, Guthridge MA.

J Biol Chem. 2013 May 24;288(21):14874-85. doi: 10.1074/jbc.M112.421669. Epub 2013 Apr 5.

PMID:
23564461
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

RasGRP1, but not RasGRP3, is required for efficient thymic β-selection and ERK activation downstream of CXCR4.

Golec DP, Dower NA, Stone JC, Baldwin TA.

PLoS One. 2013;8(1):e53300. doi: 10.1371/journal.pone.0053300. Epub 2013 Jan 7.

PMID:
23308188
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

GPCR activation of Ras and PI3Kc in neutrophils depends on PLCb2/b3 and the RasGEF RasGRP4.

Suire S, Lécureuil C, Anderson KE, Damoulakis G, Niewczas I, Davidson K, Guillou H, Pan D, Jonathan Clark, Phillip T Hawkins, Stephens L.

EMBO J. 2012 Jul 18;31(14):3118-29. doi: 10.1038/emboj.2012.167.

PMID:
22728827
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Overexpression of IL-1 receptor accessory protein in stem and progenitor cells and outcome correlation in AML and MDS.

Barreyro L, Will B, Bartholdy B, Zhou L, Todorova TI, Stanley RF, Ben-Neriah S, Montagna C, Parekh S, Pellagatti A, Boultwood J, Paietta E, Ketterling RP, Cripe L, Fernandez HF, Greenberg PL, Tallman MS, Steidl C, Mitsiades CS, Verma A, Steidl U.

Blood. 2012 Aug 9;120(6):1290-8. doi: 10.1182/blood-2012-01-404699. Epub 2012 Jun 21.

PMID:
22723552
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Bryostatin analogue-induced apoptosis in mantle cell lymphoma cell lines.

Lopez-Campistrous A, Song X, Schrier AJ, Wender PA, Dower NA, Stone JC.

Exp Hematol. 2012 Aug;40(8):646-56.e2. doi: 10.1016/j.exphem.2012.03.002. Epub 2012 Mar 28.

PMID:
22465296
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Ca-dependent Ras/Erk signaling mediates negative selection of autoreactive B cells.

Limnander A, Weiss A.

Small GTPases. 2011 Sep;2(5):282-288. Epub 2011 Sep 1.

PMID:
22292132
[PubMed]
Free PMC Article
15.

Integrating autoimmune risk loci with gene-expression data identifies specific pathogenic immune cell subsets.

Hu X, Kim H, Stahl E, Plenge R, Daly M, Raychaudhuri S.

Am J Hum Genet. 2011 Oct 7;89(4):496-506. doi: 10.1016/j.ajhg.2011.09.002. Epub 2011 Sep 29. Erratum in: Am J Hum Genet. 2011 Nov 11;89(5):682.

PMID:
21963258
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Regulation and Function of the RasGRP Family of Ras Activators in Blood Cells.

Stone JC.

Genes Cancer. 2011 Mar;2(3):320-34. doi: 10.1177/1947601911408082.

PMID:
21779502
[PubMed]
Free PMC Article
17.

RasGRP3, a Ras activator, contributes to signaling and the tumorigenic phenotype in human melanoma.

Yang D, Tao J, Li L, Kedei N, Tóth ZE, Czap A, Velasquez JF, Mihova D, Michalowski AM, Yuspa SH, Blumberg PM.

Oncogene. 2011 Nov 10;30(45):4590-600. doi: 10.1038/onc.2011.166. Epub 2011 May 23.

PMID:
21602881
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

A RasGRP, C. elegans RGEF-1b, couples external stimuli to behavior by activating LET-60 (Ras) in sensory neurons.

Chen L, Fu Y, Ren M, Xiao B, Rubin CS.

Neuron. 2011 Apr 14;70(1):51-65. doi: 10.1016/j.neuron.2011.02.039.

PMID:
21482356
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

The Ras activator RasGRP3 mediates diabetes-induced embryonic defects and affects endothelial cell migration.

Randhawa PK, Rylova S, Heinz JY, Kiser S, Fried JH, Dunworth WP, Anderson AL, Barber AT, Chappell JC, Roberts DM, Bautch VL.

Circ Res. 2011 May 13;108(10):1199-208. doi: 10.1161/CIRCRESAHA.110.230888. Epub 2011 Apr 7.

PMID:
21474816
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

STIM1, PKC-δ and RasGRP set a threshold for proapoptotic Erk signaling during B cell development.

Limnander A, Depeille P, Freedman TS, Liou J, Leitges M, Kurosaki T, Roose JP, Weiss A.

Nat Immunol. 2011 May;12(5):425-33. doi: 10.1038/ni.2016. Epub 2011 Mar 27.

PMID:
21441934
[PubMed - indexed for MEDLINE]
Free PMC Article

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