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Smoothened Regulation: A Tale of Two Signals.

Arensdorf AM, Marada S, Ogden SK.

Trends Pharmacol Sci. 2015 Sep 29. pii: S0165-6147(15)00188-1. doi: 10.1016/ [Epub ahead of print] Review.


Phospho-selective mechanisms of arrestin conformations and functions revealed by unnatural amino acid incorporation and (19)F-NMR.

Yang F, Yu X, Liu C, Qu CX, Gong Z, Liu HD, Li FH, Wang HM, He DF, Yi F, Song C, Tian CL, Xiao KH, Wang JY, Sun JP.

Nat Commun. 2015 Sep 8;6:8202. doi: 10.1038/ncomms9202.


Hedgehog Signaling in the Maintenance of Cancer Stem Cells.

Cochrane CR, Szczepny A, Watkins DN, Cain JE.

Cancers (Basel). 2015 Aug 11;7(3):1554-85. doi: 10.3390/cancers7030851. Review.


Acute upregulation of hedgehog signaling in mice causes differential effects on cranial morphology.

Singh N, Dutka T, Devenney BM, Kawasaki K, Reeves RH, Richtsmeier JT.

Dis Model Mech. 2015 Mar;8(3):271-9. doi: 10.1242/dmm.017889. Epub 2014 Dec 24.


Smoothened goes molecular: new pieces in the hedgehog signaling puzzle.

McCabe JM, Leahy DJ.

J Biol Chem. 2015 Feb 6;290(6):3500-7. doi: 10.1074/jbc.R114.617936. Epub 2014 Dec 17. Review.


Requirement of Smurf-mediated endocytosis of Patched1 in sonic hedgehog signal reception.

Yue S, Tang LY, Tang Y, Tang Y, Shen QH, Ding J, Chen Y, Zhang Z, Yu TT, Zhang YE, Cheng SY.

Elife. 2014 Jun 12;3. doi: 10.7554/eLife.02555.


Canonical and non-canonical Hedgehog signalling and the control of metabolism.

Teperino R, Aberger F, Esterbauer H, Riobo N, Pospisilik JA.

Semin Cell Dev Biol. 2014 Sep;33:81-92. doi: 10.1016/j.semcdb.2014.05.007. Epub 2014 May 23. Review.


Targeted disruption of β-arrestin 2-mediated signaling pathways by aptamer chimeras leads to inhibition of leukemic cell growth.

Kotula JW, Sun J, Li M, Pratico ED, Fereshteh MP, Ahrens DP, Sullenger BA, Kovacs JJ.

PLoS One. 2014 Apr 15;9(4):e93441. doi: 10.1371/journal.pone.0093441. eCollection 2014.


Simulations of biased agonists in the β(2) adrenergic receptor with accelerated molecular dynamics.

Tikhonova IG, Selvam B, Ivetac A, Wereszczynski J, McCammon JA.

Biochemistry. 2013 Aug 20;52(33):5593-603. doi: 10.1021/bi400499n. Epub 2013 Aug 7.


β-Arrestins in the immune system.

Jiang D, Xie T, Liang J, Noble PW.

Prog Mol Biol Transl Sci. 2013;118:359-93. doi: 10.1016/B978-0-12-394440-5.00014-0. Review.


Structure of the human smoothened receptor bound to an antitumour agent.

Wang C, Wu H, Katritch V, Han GW, Huang XP, Liu W, Siu FY, Roth BL, Cherezov V, Stevens RC.

Nature. 2013 May 16;497(7449):338-43. doi: 10.1038/nature12167. Epub 2013 May 1.


Smoothened is a master regulator of adult liver repair.

Michelotti GA, Xie G, Swiderska M, Choi SS, Karaca G, Krüger L, Premont R, Yang L, Syn WK, Metzger D, Diehl AM.

J Clin Invest. 2013 Jun;123(6):2380-94.


Phosphorylation on Ser-279 and Ser-282 of connexin43 regulates endocytosis and gap junction assembly in pancreatic cancer cells.

Johnson KE, Mitra S, Katoch P, Kelsey LS, Johnson KR, Mehta PP.

Mol Biol Cell. 2013 Mar;24(6):715-33. doi: 10.1091/mbc.E12-07-0537. Epub 2013 Jan 30.


Decoding the phosphorylation code in Hedgehog signal transduction.

Chen Y, Jiang J.

Cell Res. 2013 Feb;23(2):186-200. doi: 10.1038/cr.2013.10. Epub 2013 Jan 22. Review.


The Hedgehog signal transduction network.

Robbins DJ, Fei DL, Riobo NA.

Sci Signal. 2012 Oct 16;5(246):re6. doi: 10.1126/scisignal.2002906. Review.


Identification of a novel Smoothened antagonist that potently suppresses Hedgehog signaling.

Wang J, Mook RA Jr, Lu J, Gooden DM, Ribeiro A, Guo A, Barak LS, Lyerly HK, Chen W.

Bioorg Med Chem. 2012 Nov 15;20(22):6751-7. doi: 10.1016/j.bmc.2012.09.030. Epub 2012 Sep 23.


β-Arrestin2 mediates the initiation and progression of myeloid leukemia.

Fereshteh M, Ito T, Kovacs JJ, Zhao C, Kwon HY, Tornini V, Konuma T, Chen M, Lefkowitz RJ, Reya T.

Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12532-7. doi: 10.1073/pnas.1209815109. Epub 2012 Jul 5.


The insecticide synergist piperonyl butoxide inhibits hedgehog signaling: assessing chemical risks.

Wang J, Lu J, Mook RA Jr, Zhang M, Zhao S, Barak LS, Freedman JH, Lyerly HK, Chen W.

Toxicol Sci. 2012 Aug;128(2):517-23. doi: 10.1093/toxsci/kfs165. Epub 2012 May 1.


An expanded family of arrestins regulate metabolism.

Patwari P, Lee RT.

Trends Endocrinol Metab. 2012 May;23(5):216-22. doi: 10.1016/j.tem.2012.03.003. Epub 2012 Apr 18. Review.


Hedgehog secretion and signal transduction in vertebrates.

Ryan KE, Chiang C.

J Biol Chem. 2012 May 25;287(22):17905-13. doi: 10.1074/jbc.R112.356006. Epub 2012 Apr 2. Review.

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