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Items: 1 to 20 of 77


G Protein-Coupled Receptors (GPCRs) in Alzheimer's Disease: A Focus on BACE1 Related GPCRs.

Zhao J, Deng Y, Jiang Z, Qing H.

Front Aging Neurosci. 2016 Mar 24;8:58. doi: 10.3389/fnagi.2016.00058. eCollection 2016. Review.


Amyloid β-protein oligomers upregulate the β-secretase, BACE1, through a post-translational mechanism involving its altered subcellular distribution in neurons.

Mamada N, Tanokashira D, Hosaka A, Kametani F, Tamaoka A, Araki W.

Mol Brain. 2015 Nov 9;8(1):73. doi: 10.1186/s13041-015-0163-5.


LRP1 Downregulates the Alzheimer's β-Secretase BACE1 by Modulating Its Intraneuronal Trafficking(1,2,3).

Tanokashira D, Motoki K, Minegishi S, Hosaka A, Mamada N, Tamaoka A, Okada T, Lakshmana MK, Araki W.

eNeuro. 2015 Apr 22;2(2). pii: ENEURO.0006-15.2015. doi: 10.1523/ENEURO.0006-15.2015. eCollection 2015 Mar-Apr.


The Golgi-Localized γ-Ear-Containing ARF-Binding (GGA) Proteins Alter Amyloid-β Precursor Protein (APP) Processing through Interaction of Their GAE Domain with the Beta-Site APP Cleaving Enzyme 1 (BACE1).

von Einem B, Wahler A, Schips T, Serrano-Pozo A, Proepper C, Boeckers TM, Rueck A, Wirth T, Hyman BT, Danzer KM, Thal DR, von Arnim CA.

PLoS One. 2015 Jun 8;10(6):e0129047. doi: 10.1371/journal.pone.0129047. eCollection 2015.


Overexpression of the Insulin-Like Growth Factor II Receptor Increases β-Amyloid Production and Affects Cell Viability.

Wang Y, Buggia-Prévot V, Zavorka ME, Bleackley RC, MacDonald RG, Thinakaran G, Kar S.

Mol Cell Biol. 2015 Jul;35(14):2368-84. doi: 10.1128/MCB.01338-14. Epub 2015 May 4.


Dysregulation of protein trafficking in neurodegeneration.

Wang X, Huang T, Bu G, Xu H.

Mol Neurodegener. 2014 Aug 25;9:31. doi: 10.1186/1750-1326-9-31. Review.


The normal and pathologic roles of the Alzheimer's β-secretase, BACE1.

Kandalepas PC, Vassar R.

Curr Alzheimer Res. 2014;11(5):441-9. Review.


Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects.

Vassar R, Kuhn PH, Haass C, Kennedy ME, Rajendran L, Wong PC, Lichtenthaler SF.

J Neurochem. 2014 Jul;130(1):4-28. doi: 10.1111/jnc.12715. Epub 2014 Apr 19. Review.


Retromer: a master conductor of endosome sorting.

Burd C, Cullen PJ.

Cold Spring Harb Perspect Biol. 2014 Feb 1;6(2). pii: a016774. doi: 10.1101/cshperspect.a016774. Review.


Trafficking regulation of proteins in Alzheimer's disease.

Jiang S, Li Y, Zhang X, Bu G, Xu H, Zhang YW.

Mol Neurodegener. 2014 Jan 11;9:6. doi: 10.1186/1750-1326-9-6. Review.


Axonal BACE1 dynamics and targeting in hippocampal neurons: a role for Rab11 GTPase.

Buggia-Prévot V, Fernandez CG, Riordan S, Vetrivel KS, Roseman J, Waters J, Bindokas VP, Vassar R, Thinakaran G.

Mol Neurodegener. 2014 Jan 4;9:1. doi: 10.1186/1750-1326-9-1.


A paired RNAi and RabGAP overexpression screen identifies Rab11 as a regulator of β-amyloid production.

Udayar V, Buggia-Prévot V, Guerreiro RL, Siegel G, Rambabu N, Soohoo AL, Ponnusamy M, Siegenthaler B, Bali J; AESG, Simons M, Ries J, Puthenveedu MA, Hardy J, Thinakaran G, Rajendran L.

Cell Rep. 2013 Dec 26;5(6):1536-51. doi: 10.1016/j.celrep.2013.12.005.


Rheb GTPase regulates β-secretase levels and amyloid β generation.

Shahani N, Pryor W, Swarnkar S, Kholodilov N, Thinakaran G, Burke RE, Subramaniam S.

J Biol Chem. 2014 Feb 28;289(9):5799-808. doi: 10.1074/jbc.M113.532713. Epub 2013 Dec 24.


The role of APP and BACE1 trafficking in APP processing and amyloid-β generation.

Zhang X, Song W.

Alzheimers Res Ther. 2013 Oct 8;5(5):46. doi: 10.1186/alzrt211. eCollection 2013. Review.


Increased expression of reticulon 3 in neurons leads to reduced axonal transport of β site amyloid precursor protein-cleaving enzyme 1.

Deng M, He W, Tan Y, Han H, Hu X, Xia K, Zhang Z, Yan R.

J Biol Chem. 2013 Oct 18;288(42):30236-45. doi: 10.1074/jbc.M113.480079. Epub 2013 Sep 4.


Structure-activity relationship of memapsin 2: implications on physiological functions and Alzheimer's disease.

Li X, Hong L, Coughlan K, Wang L, Cao L, Tang J.

Acta Biochim Biophys Sin (Shanghai). 2013 Aug;45(8):613-21. doi: 10.1093/abbs/gmt050. Epub 2013 May 15. Review.


Mild oxidative stress induces redistribution of BACE1 in non-apoptotic conditions and promotes the amyloidogenic processing of Alzheimer's disease amyloid precursor protein.

Tan JL, Li QX, Ciccotosto GD, Crouch PJ, Culvenor JG, White AR, Evin G.

PLoS One. 2013 Apr 17;8(4):e61246. doi: 10.1371/journal.pone.0061246. Print 2013.


A role for cargo in Arf-dependent adaptor recruitment.

Caster AH, Sztul E, Kahn RA.

J Biol Chem. 2013 May 24;288(21):14788-804. doi: 10.1074/jbc.M113.453621. Epub 2013 Apr 9.


Advances with RNA interference in Alzheimer's disease research.

Chen S, Ge X, Chen Y, Lv N, Liu Z, Yuan W.

Drug Des Devel Ther. 2013;7:117-25. doi: 10.2147/DDDT.S40229. Epub 2013 Feb 22. Review.

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