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Items: 1 to 20 of 23

1.
2.

Loss of presenilin 2 is associated with increased iPLA2 activity and lung tumor development.

Yun HM, Park MH, Kim DH, Ahn YJ, Park KR, Kim TM, Yun NY, Jung YS, Hwang DY, Yoon DY, Han SB, Hong JT.

Oncogene. 2014 Oct 30;33(44):5193-200. doi: 10.1038/onc.2014.128. Epub 2014 May 26.

3.

Membrane tethered delta activates notch and reveals a role for spatio-mechanical regulation of the signaling pathway.

Narui Y, Salaita K.

Biophys J. 2013 Dec 17;105(12):2655-65. doi: 10.1016/j.bpj.2013.11.012.

4.

Modeling Alzheimer's disease in mouse without mutant protein overexpression: cooperative and independent effects of Aβ and tau.

Guo Q, Li H, Cole AL, Hur JY, Li Y, Zheng H.

PLoS One. 2013 Nov 20;8(11):e80706. doi: 10.1371/journal.pone.0080706. eCollection 2013.

5.

γ-Secretase inhibitors and modulators.

Golde TE, Koo EH, Felsenstein KM, Osborne BA, Miele L.

Biochim Biophys Acta. 2013 Dec;1828(12):2898-907. doi: 10.1016/j.bbamem.2013.06.005. Epub 2013 Jun 17. Review.

6.

Structural biology of presenilins and signal peptide peptidases.

Tomita T, Iwatsubo T.

J Biol Chem. 2013 May 24;288(21):14673-80. doi: 10.1074/jbc.R113.463281. Epub 2013 Apr 12. Review.

7.

Retention in endoplasmic reticulum 1 (RER1) modulates amyloid-β (Aβ) production by altering trafficking of γ-secretase and amyloid precursor protein (APP).

Park HJ, Shabashvili D, Nekorchuk MD, Shyqyriu E, Jung JI, Ladd TB, Moore BD, Felsenstein KM, Golde TE, Kim SH.

J Biol Chem. 2012 Nov 23;287(48):40629-40. doi: 10.1074/jbc.M112.418442. Epub 2012 Oct 5.

8.

Trafficking and proteolytic processing of APP.

Haass C, Kaether C, Thinakaran G, Sisodia S.

Cold Spring Harb Perspect Med. 2012 May;2(5):a006270. doi: 10.1101/cshperspect.a006270. Review.

9.

Development of clickable active site-directed photoaffinity probes for γ-secretase.

Crump CJ, am Ende CW, Ballard TE, Pozdnyakov N, Pettersson M, Chau DM, Bales KR, Li YM, Johnson DS.

Bioorg Med Chem Lett. 2012 Apr 15;22(8):2997-3000. doi: 10.1016/j.bmcl.2012.02.027. Epub 2012 Feb 20.

10.

Neutralization of the γ-secretase activity by monoclonal antibody against extracellular domain of nicastrin.

Hayashi I, Takatori S, Urano Y, Miyake Y, Takagi J, Sakata-Yanagimoto M, Iwanari H, Osawa S, Morohashi Y, Li T, Wong PC, Chiba S, Kodama T, Hamakubo T, Tomita T, Iwatsubo T.

Oncogene. 2012 Feb 9;31(6):787-98. doi: 10.1038/onc.2011.265. Epub 2011 Jul 4.

11.

The biomedical discourse relation bank.

Prasad R, McRoy S, Frid N, Joshi A, Yu H.

BMC Bioinformatics. 2011 May 23;12:188. doi: 10.1186/1471-2105-12-188.

12.

Small molecule inhibitors of amyloid β peptide aggregation as a potential therapeutic strategy for Alzheimer's disease.

Nie Q, Du XG, Geng MY.

Acta Pharmacol Sin. 2011 May;32(5):545-51. doi: 10.1038/aps.2011.14. Epub 2011 Apr 18. Review.

13.

APP processing in Alzheimer's disease.

Zhang YW, Thompson R, Zhang H, Xu H.

Mol Brain. 2011 Jan 7;4:3. doi: 10.1186/1756-6606-4-3. Review.

14.

γ-secretase-dependent cleavage initiates notch signaling from the plasma membrane.

Sorensen EB, Conner SD.

Traffic. 2010 Sep;11(9):1234-45. doi: 10.1111/j.1600-0854.2010.01090.x. Epub 2010 Jun 21.

15.

Synaptic and endosomal localization of active gamma-secretase in rat brain.

Frykman S, Hur JY, Frånberg J, Aoki M, Winblad B, Nahalkova J, Behbahani H, Tjernberg LO.

PLoS One. 2010 Jan 28;5(1):e8948. doi: 10.1371/journal.pone.0008948.

16.

Controlling destiny through chemistry: small-molecule regulators of cell fate.

Firestone AJ, Chen JK.

ACS Chem Biol. 2010 Jan 15;5(1):15-34. doi: 10.1021/cb900249y. Review.

17.

Modulation of gamma-secretase specificity using small molecule allosteric inhibitors.

Shelton CC, Zhu L, Chau D, Yang L, Wang R, Djaballah H, Zheng H, Li YM.

Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20228-33. doi: 10.1073/pnas.0910757106. Epub 2009 Nov 11.

18.

The canonical Notch signaling pathway: unfolding the activation mechanism.

Kopan R, Ilagan MX.

Cell. 2009 Apr 17;137(2):216-33. doi: 10.1016/j.cell.2009.03.045. Review.

19.

Intracellular trafficking of presenilin 1 is regulated by beta-amyloid precursor protein and phospholipase D1.

Liu Y, Zhang YW, Wang X, Zhang H, You X, Liao FF, Xu H.

J Biol Chem. 2009 May 1;284(18):12145-52. doi: 10.1074/jbc.M808497200. Epub 2009 Mar 10.

20.

Genetic dissection of gamma-secretase-dependent and -independent functions of presenilin in regulating neuronal cell cycle and cell death.

Kallhoff-Munoz V, Hu L, Chen X, Pautler RG, Zheng H.

J Neurosci. 2008 Oct 29;28(44):11421-31. doi: 10.1523/JNEUROSCI.2873-08.2008.

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