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Items: 1 to 20 of 54

1.

Defective Expression of the Mitochondrial-tRNA Modifying Enzyme GTPBP3 Triggers AMPK-Mediated Adaptive Responses Involving Complex I Assembly Factors, Uncoupling Protein 2, and the Mitochondrial Pyruvate Carrier.

Martínez-Zamora A, Meseguer S, Esteve JM, Villarroya M, Aguado C, Enríquez JA, Knecht E, Armengod ME.

PLoS One. 2015 Dec 7;10(12):e0144273. doi: 10.1371/journal.pone.0144273. eCollection 2015.

2.

Mitochondrial transcript maturation and its disorders.

Van Haute L, Pearce SF, Powell CA, D'Souza AR, Nicholls TJ, Minczuk M.

J Inherit Metab Dis. 2015 Jul;38(4):655-80. doi: 10.1007/s10545-015-9859-z. Epub 2015 May 28.

3.

MTO1 worked as a modifier in the aminoglycosides sensitivity of yeast carrying a mitochondrial 15S rRNA C1477G mutation.

Zhu X, He X, Wang W, Zhou Q, Yu Z, Dai Y, Zhu X, Yan Q.

PLoS One. 2015 Apr 21;10(4):e0124200. doi: 10.1371/journal.pone.0124200. eCollection 2015.

4.

Abbreviated Pathway for Biosynthesis of 2-Thiouridine in Bacillus subtilis.

Black KA, Dos Santos PC.

J Bacteriol. 2015 Jun;197(11):1952-62. doi: 10.1128/JB.02625-14. Epub 2015 Mar 30.

5.

Nuclear-encoded factors involved in post-transcriptional processing and modification of mitochondrial tRNAs in human disease.

Powell CA, Nicholls TJ, Minczuk M.

Front Genet. 2015 Mar 10;6:79. doi: 10.3389/fgene.2015.00079. eCollection 2015. Review.

6.

tRNA biology in mitochondria.

Salinas-Giegé T, Giegé R, Giegé P.

Int J Mol Sci. 2015 Feb 27;16(3):4518-59. doi: 10.3390/ijms16034518. Review.

7.

Modification of the wobble uridine in bacterial and mitochondrial tRNAs reading NNA/NNG triplets of 2-codon boxes.

Armengod ME, Meseguer S, Villarroya M, Prado S, Moukadiri I, Ruiz-Partida R, Garzón MJ, Navarro-González C, Martínez-Zamora A.

RNA Biol. 2014;11(12):1495-507. doi: 10.4161/15476286.2014.992269. Review.

8.

MTO1 mediates tissue specificity of OXPHOS defects via tRNA modification and translation optimization, which can be bypassed by dietary intervention.

Tischner C, Hofer A, Wulff V, Stepek J, Dumitru I, Becker L, Haack T, Kremer L, Datta AN, Sperl W, Floss T, Wurst W, Chrzanowska-Lightowlers Z, De Angelis MH, Klopstock T, Prokisch H, Wenz T.

Hum Mol Genet. 2015 Apr 15;24(8):2247-66. doi: 10.1093/hmg/ddu743. Epub 2014 Dec 30.

PMID:
25552653
9.

MTO1-deficient mouse model mirrors the human phenotype showing complex I defect and cardiomyopathy.

Becker L, Kling E, Schiller E, Zeh R, Schrewe A, Hölter SM, Mossbrugger I, Calzada-Wack J, Strecker V, Wittig I, Dumitru I, Wenz T, Bender A, Aichler M, Janik D, Neff F, Walch A, Quintanilla-Fend L, Floss T, Bekeredjian R, Gailus-Durner V, Fuchs H, Wurst W, Meitinger T, Prokisch H, de Angelis MH, Klopstock T.

PLoS One. 2014 Dec 15;9(12):e114918. doi: 10.1371/journal.pone.0114918. eCollection 2014.

10.

Tissue taurine depletion alters metabolic response to exercise and reduces running capacity in mice.

Ito T, Yoshikawa N, Schaffer SW, Azuma J.

J Amino Acids. 2014;2014:964680. doi: 10.1155/2014/964680. Epub 2014 Nov 12.

11.

tRNA thiolation links translation to stress responses in Saccharomyces cerevisiae.

Damon JR, Pincus D, Ploegh HL.

Mol Biol Cell. 2015 Jan 15;26(2):270-82. doi: 10.1091/mbc.E14-06-1145. Epub 2014 Nov 12.

12.

Methylated nucleosides in tRNA and tRNA methyltransferases.

Hori H.

Front Genet. 2014 May 23;5:144. doi: 10.3389/fgene.2014.00144. eCollection 2014. Review.

13.

A complete landscape of post-transcriptional modifications in mammalian mitochondrial tRNAs.

Suzuki T, Suzuki T.

Nucleic Acids Res. 2014 Jun;42(11):7346-57. doi: 10.1093/nar/gku390. Epub 2014 May 15.

14.

Biosynthesis and functions of sulfur modifications in tRNA.

Shigi N.

Front Genet. 2014 Apr 2;5:67. doi: 10.3389/fgene.2014.00067. eCollection 2014. Review.

15.

Mechanistic study on the nuclear modifier gene MSS1 mutation suppressing neomycin sensitivity of the mitochondrial 15S rRNA C1477G mutation in Saccharomyces cerevisiae.

Zhou Q, Wang W, He X, Zhu X, Shen Y, Yu Z, Wang X, Qi X, Zhang X, Fan M, Dai Y, Yang S, Yan Q.

PLoS One. 2014 Mar 3;9(3):e90336. doi: 10.1371/journal.pone.0090336. eCollection 2014.

16.

Nuclear modifier MTO2 modulates the aminoglycoside-sensitivity of mitochondrial 15S rRNA C1477G mutation in Saccharomyces cerevisiae.

He X, Zhu X, Wang X, Wang W, Dai Y, Yan Q.

PLoS One. 2013 Dec 10;8(12):e81490. doi: 10.1371/journal.pone.0081490. eCollection 2013.

17.

Posttranscriptional RNA Modifications: playing metabolic games in a cell's chemical Legoland.

Helm M, Alfonzo JD.

Chem Biol. 2014 Feb 20;21(2):174-85. doi: 10.1016/j.chembiol.2013.10.015. Epub 2013 Dec 5. Review.

18.

New insights into the RNA-based mechanism of action of the anticancer drug 5'-fluorouracil in eukaryotic cells.

Mojardín L, Botet J, Quintales L, Moreno S, Salas M.

PLoS One. 2013 Nov 1;8(11):e78172. doi: 10.1371/journal.pone.0078172. eCollection 2013.

19.

MTO1 mutations are associated with hypertrophic cardiomyopathy and lactic acidosis and cause respiratory chain deficiency in humans and yeast.

Baruffini E, Dallabona C, Invernizzi F, Yarham JW, Melchionda L, Blakely EL, Lamantea E, Donnini C, Santra S, Vijayaraghavan S, Roper HP, Burlina A, Kopajtich R, Walther A, Strom TM, Haack TB, Prokisch H, Taylor RW, Ferrero I, Zeviani M, Ghezzi D.

Hum Mutat. 2013 Nov;34(11):1501-9. doi: 10.1002/humu.22393. Epub 2013 Sep 17.

20.

tRNA tKUUU, tQUUG, and tEUUC wobble position modifications fine-tune protein translation by promoting ribosome A-site binding.

Rezgui VA, Tyagi K, Ranjan N, Konevega AL, Mittelstaet J, Rodnina MV, Peter M, Pedrioli PG.

Proc Natl Acad Sci U S A. 2013 Jul 23;110(30):12289-94. doi: 10.1073/pnas.1300781110. Epub 2013 Jul 8.

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