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Items: 1 to 20 of 21


Loss of the PGE2 receptor EP1 enhances bone acquisition, which protects against age and ovariectomy-induced impairments in bone strength.

Zhang M, Feigenson M, Sheu TJ, Awad HA, Schwarz EM, Jonason JH, Loiselle AE, O'Keefe RJ.

Bone. 2015 Mar;72:92-100. doi: 10.1016/j.bone.2014.11.018. Epub 2014 Nov 29.


Prostacyclin regulates bone growth via the Epac/Rap1 pathway.

Hutchison MR, White PC.

Endocrinology. 2015 Feb;156(2):499-510. doi: 10.1210/en.2014-1348. Epub 2014 Nov 18.


Role of G-proteins in the differentiation of epiphyseal chondrocytes.

Chagin AS, Kronenberg HM.

J Mol Endocrinol. 2014 Oct;53(2):R39-45. doi: 10.1530/JME-14-0093. Epub 2014 Jun 30. Review.


Immunohistochemical localization of key arachidonic acid metabolism enzymes during fracture healing in mice.

Lin HN, O'Connor JP.

PLoS One. 2014 Feb 7;9(2):e88423. doi: 10.1371/journal.pone.0088423. eCollection 2014.


BMP-2 induces ATF4 phosphorylation in chondrocytes through a COX-2/PGE2 dependent signaling pathway.

Li TF, Yukata K, Yin G, Sheu T, Maruyama T, Jonason JH, Hsu W, Zhang X, Xiao G, Konttinen YT, Chen D, O'Keefe RJ.

Osteoarthritis Cartilage. 2014 Mar;22(3):481-9. doi: 10.1016/j.joca.2013.12.020. Epub 2014 Jan 11.


NSAID therapy effects on healing of bone, tendon, and the enthesis.

Su B, O'Connor JP.

J Appl Physiol (1985). 2013 Sep;115(6):892-9. doi: 10.1152/japplphysiol.00053.2013. Epub 2013 Jul 18. Review.


GSK-3α and GSK-3β proteins are involved in early stages of chondrocyte differentiation with functional redundancy through RelA protein phosphorylation.

Itoh S, Saito T, Hirata M, Ushita M, Ikeda T, Woodgett JR, Algül H, Schmid RM, Chung UI, Kawaguchi H.

J Biol Chem. 2012 Aug 24;287(35):29227-36. doi: 10.1074/jbc.M112.372086. Epub 2012 Jul 3.


Developmental mechanisms in articular cartilage degradation in osteoarthritis.

Tchetina EV.

Arthritis. 2011;2011:683970. doi: 10.1155/2011/683970. Epub 2010 Dec 29.


A 3D cartilage - inflammatory cell culture system for the modeling of human osteoarthritis.

Sun L, Wang X, Kaplan DL.

Biomaterials. 2011 Aug;32(24):5581-9. doi: 10.1016/j.biomaterials.2011.04.028. Epub 2011 May 12.


Roles of inflammatory and anabolic cytokines in cartilage metabolism: signals and multiple effectors converge upon MMP-13 regulation in osteoarthritis.

Goldring MB, Otero M, Plumb DA, Dragomir C, Favero M, El Hachem K, Hashimoto K, Roach HI, Olivotto E, Borzì RM, Marcu KB.

Eur Cell Mater. 2011 Feb 24;21:202-20.


Protein kinase A regulates caspase-1 via Ets-1 in bone stromal cell-derived lesions: a link between cyclic AMP and pro-inflammatory pathways in osteoblast progenitors.

Almeida MQ, Tsang KM, Cheadle C, Watkins T, Grivel JC, Nesterova M, Goldbach-Mansky R, Stratakis CA.

Hum Mol Genet. 2011 Jan 1;20(1):165-75. doi: 10.1093/hmg/ddq455. Epub 2010 Oct 11.


EP1(-/-) mice have enhanced osteoblast differentiation and accelerated fracture repair.

Zhang M, Ho HC, Sheu TJ, Breyer MD, Flick LM, Jonason JH, Awad HA, Schwarz EM, O'Keefe RJ.

J Bone Miner Res. 2011 Apr;26(4):792-802. doi: 10.1002/jbmr.272.


Spatial and temporal regulation of gene expression in the mammalian growth plate.

Lui JC, Andrade AC, Forcinito P, Hegde A, Chen W, Baron J, Nilsson O.

Bone. 2010 May;46(5):1380-90. doi: 10.1016/j.bone.2010.01.373. Epub 2010 Jan 22.


Prostaglandin E2 inhibits BMP signaling and delays chondrocyte maturation.

Clark CA, Li TF, Kim KO, Drissi H, Zuscik MJ, Zhang X, O'Keefe RJ.

J Orthop Res. 2009 Jun;27(6):785-92. doi: 10.1002/jor.20805.


Reduced COX-2 expression in aged mice is associated with impaired fracture healing.

Naik AA, Xie C, Zuscik MJ, Kingsley P, Schwarz EM, Awad H, Guldberg R, Drissi H, Puzas JE, Boyce B, Zhang X, O'Keefe RJ.

J Bone Miner Res. 2009 Feb;24(2):251-64. doi: 10.1359/jbmr.081002.


C-type natriuretic peptide regulates endochondral bone growth through p38 MAP kinase-dependent and -independent pathways.

Agoston H, Khan S, James CG, Gillespie JR, Serra R, Stanton LA, Beier F.

BMC Dev Biol. 2007 Mar 20;7:18.

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