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Role of chrysin on expression of insulin signaling molecules.

Satyanarayana K, Sravanthi K, Shaker IA, Ponnulakshmi R, Selvaraj J.

J Ayurveda Integr Med. 2015 Oct-Dec;6(4):248-58. doi: 10.4103/0975-9476.157951.


Insulin Receptor Substrate 1, the Hub Linking Follicle-stimulating Hormone to Phosphatidylinositol 3-Kinase Activation.

Law NC, Hunzicker-Dunn ME.

J Biol Chem. 2016 Feb 26;291(9):4547-60. doi: 10.1074/jbc.M115.698761. Epub 2015 Dec 23.


Molecular approach to identify antidiabetic potential of Azadirachta indica.

Satyanarayana K, Sravanthi K, Shaker IA, Ponnulakshmi R.

J Ayurveda Integr Med. 2015 Jul-Sep;6(3):165-74. doi: 10.4103/0975-9476.157950.


Activation of G proteins by GIV-GEF is a pivot point for insulin resistance and sensitivity.

Ma GS, Lopez-Sanchez I, Aznar N, Kalogriopoulos N, Pedram S, Midde K, Ciaraldi TP, Henry RR, Ghosh P.

Mol Biol Cell. 2015 Nov 15;26(23):4209-23. doi: 10.1091/mbc.E15-08-0553. Epub 2015 Sep 16.


DAG tales: the multiple faces of diacylglycerol--stereochemistry, metabolism, and signaling.

Eichmann TO, Lass A.

Cell Mol Life Sci. 2015 Oct;72(20):3931-52. doi: 10.1007/s00018-015-1982-3. Epub 2015 Jul 8. Review.


High-fat load: mechanism(s) of insulin resistance in skeletal muscle.

Lark DS, Fisher-Wellman KH, Neufer PD.

Int J Obes Suppl. 2012 Dec;2(Suppl 2):S31-S36.


Deep proteomics of mouse skeletal muscle enables quantitation of protein isoforms, metabolic pathways, and transcription factors.

Deshmukh AS, Murgia M, Nagaraj N, Treebak JT, Cox J, Mann M.

Mol Cell Proteomics. 2015 Apr;14(4):841-53. doi: 10.1074/mcp.M114.044222. Epub 2015 Jan 22.


Inhibited insulin signaling in mouse hepatocytes is associated with increased phosphatidic acid but not diacylglycerol.

Zhang C, Hwarng G, Cooper DE, Grevengoed TJ, Eaton JM, Natarajan V, Harris TE, Coleman RA.

J Biol Chem. 2015 Feb 6;290(6):3519-28. doi: 10.1074/jbc.M114.602789. Epub 2014 Dec 15.


Insulin resistance and muscle insulin receptor substrate-1 serine hyperphosphorylation.

Stuart CA, Howell ME, Cartwright BM, McCurry MP, Lee ML, Ramsey MW, Stone MH.

Physiol Rep. 2014 Dec 3;2(12). pii: e12236. doi: 10.14814/phy2.12236. Print 2014 Dec 1.


Genetic activation of pyruvate dehydrogenase alters oxidative substrate selection to induce skeletal muscle insulin resistance.

Rahimi Y, Camporez JP, Petersen MC, Pesta D, Perry RJ, Jurczak MJ, Cline GW, Shulman GI.

Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):16508-13. doi: 10.1073/pnas.1419104111. Epub 2014 Nov 3.


Computer-aided targeting of the PI3K/Akt/mTOR pathway: toxicity reduction and therapeutic opportunities.

Li T, Wang G.

Int J Mol Sci. 2014 Oct 20;15(10):18856-91. doi: 10.3390/ijms151018856. Review.


Role of diacylglycerol activation of PKCθ in lipid-induced muscle insulin resistance in humans.

Szendroedi J, Yoshimura T, Phielix E, Koliaki C, Marcucci M, Zhang D, Jelenik T, Müller J, Herder C, Nowotny P, Shulman GI, Roden M.

Proc Natl Acad Sci U S A. 2014 Jul 1;111(26):9597-602. doi: 10.1073/pnas.1409229111. Epub 2014 Jun 16.


Insulin and metabolic stress stimulate multisite serine/threonine phosphorylation of insulin receptor substrate 1 and inhibit tyrosine phosphorylation.

Hançer NJ, Qiu W, Cherella C, Li Y, Copps KD, White MF.

J Biol Chem. 2014 May 2;289(18):12467-84. doi: 10.1074/jbc.M114.554162. Epub 2014 Mar 20.


Bone-specific insulin resistance disrupts whole-body glucose homeostasis via decreased osteocalcin activation.

Wei J, Ferron M, Clarke CJ, Hannun YA, Jiang H, Blaner WS, Karsenty G.

J Clin Invest. 2014 Apr;124(4):1-13. doi: 10.1172/JCI72323. Epub 2014 Mar 18.


Inputs and outputs of insulin receptor.

Du Y, Wei T.

Protein Cell. 2014 Mar;5(3):203-13. doi: 10.1007/s13238-014-0030-7. Epub 2014 Mar 16. Review.


Insulin receptor signaling in normal and insulin-resistant states.

Boucher J, Kleinridders A, Kahn CR.

Cold Spring Harb Perspect Biol. 2014 Jan 1;6(1). pii: a009191. doi: 10.1101/cshperspect.a009191. Review.


The effects of obesity on skeletal muscle regeneration.

Akhmedov D, Berdeaux R.

Front Physiol. 2013 Dec 17;4:371. doi: 10.3389/fphys.2013.00371. Review.


Impact of insulin deprivation and treatment on sphingolipid distribution in different muscle subcellular compartments of streptozotocin-diabetic C57Bl/6 mice.

Zabielski P, Blachnio-Zabielska A, Lanza IR, Gopala S, Manjunatha S, Jakaitis DR, Persson XM, Gransee J, Klaus KA, Schimke JM, Jensen MD, Nair KS.

Am J Physiol Endocrinol Metab. 2014 Mar 1;306(5):E529-42. doi: 10.1152/ajpendo.00610.2012. Epub 2013 Dec 24.


Suppression of protein kinase C theta contributes to enhanced myogenesis in vitro via IRS1 and ERK1/2 phosphorylation.

Marino JS, Hinds TD Jr, Potter RA, Ondrus E, Onion JL, Dowling A, McLoughlin TJ, Sanchez ER, Hill JW.

BMC Cell Biol. 2013 Sep 21;14:39. doi: 10.1186/1471-2121-14-39.


Protein kinase C-theta (PKCθ) phosphorylates and inhibits the guanine exchange factor, GIV/Girdin.

López-Sánchez I, Garcia-Marcos M, Mittal Y, Aznar N, Farquhar MG, Ghosh P.

Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5510-5. doi: 10.1073/pnas.1303392110. Epub 2013 Mar 18.

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