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Items: 1 to 20 of 105


Insulin Signaling and Heart Failure.

Riehle C, Abel ED.

Circ Res. 2016 Apr 1;118(7):1151-69. doi: 10.1161/CIRCRESAHA.116.306206. Review.


From Bench to Bedside: New Approaches to Therapeutic Discovery for Heart Failure.

Bernardo BC, Blaxall BC.

Heart Lung Circ. 2016 May;25(5):425-34. doi: 10.1016/j.hlc.2016.01.002. Epub 2016 Jan 19. Review.


Tripartite motif 32 prevents pathological cardiac hypertrophy.

Chen L, Huang J, Ji Y, Zhang X, Wang P, Deng K, Jiang X, Ma G, Li H.

Clin Sci (Lond). 2016 May 1;130(10):813-28. doi: 10.1042/CS20150619. Epub 2016 Feb 16.


Insulin-like growth factor 1 prevents diastolic and systolic dysfunction associated with cardiomyopathy and preserves adrenergic sensitivity.

Roof SR, Boslett J, Russell D, Del Rio C, Alecusan J, Zweier JL, Ziolo MT, Hamlin R, Mohler PJ, Curran J.

Acta Physiol (Oxf). 2016 Apr;216(4):421-34. doi: 10.1111/apha.12607. Epub 2015 Oct 8.


Phosphoinositide 3-Kinase Gamma Contributes to Neuroinflammation in a Rat Model of Surgical Brain Injury.

Huang L, Sherchan P, Wang Y, Reis C, Applegate RL 2nd, Tang J, Zhang JH.

J Neurosci. 2015 Jul 22;35(29):10390-401. doi: 10.1523/JNEUROSCI.0546-15.2015.


Inhibition of class IA PI3K enzymes in non-small cell lung cancer cells uncovers functional compensation among isoforms.

Stamatkin C, Ratermann KL, Overley CW, Black EP.

Cancer Biol Ther. 2015;16(9):1341-52. doi: 10.1080/15384047.2015.1070986. Epub 2015 Jul 15.


The critical role of Akt in cardiovascular function.

Abeyrathna P, Su Y.

Vascul Pharmacol. 2015 Nov;74:38-48. doi: 10.1016/j.vph.2015.05.008. Epub 2015 May 27. Review.


PI3K signaling in the locus coeruleus: a new molecular pathway for ADHD research.

Darcq E, Kieffer BL.

EMBO Mol Med. 2015 Apr 29;7(7):859-61. doi: 10.15252/emmm.201505266. No abstract available.


Nuclear PI3K signaling in cell growth and tumorigenesis.

Davis WJ, Lehmann PZ, Li W.

Front Cell Dev Biol. 2015 Apr 13;3:24. doi: 10.3389/fcell.2015.00024. eCollection 2015. Review.


Lack of kinase-independent activity of PI3Kγ in locus coeruleus induces ADHD symptoms through increased CREB signaling.

D'Andrea I, Fardella V, Fardella S, Pallante F, Ghigo A, Iacobucci R, Maffei A, Hirsch E, Lembo G, Carnevale D.

EMBO Mol Med. 2015 Apr 16;7(7):904-17. doi: 10.15252/emmm.201404697.


Targeted disruption of PDE3B, but not PDE3A, protects murine heart from ischemia/reperfusion injury.

Chung YW, Lagranha C, Chen Y, Sun J, Tong G, Hockman SC, Ahmad F, Esfahani SG, Bae DH, Polidovitch N, Wu J, Rhee DK, Lee BS, Gucek M, Daniels MP, Brantner CA, Backx PH, Murphy E, Manganiello VC.

Proc Natl Acad Sci U S A. 2015 Apr 28;112(17):E2253-62. doi: 10.1073/pnas.1416230112. Epub 2015 Apr 15.


Control of cardiac repolarization by phosphoinositide 3-kinase signaling to ion channels.

Ballou LM, Lin RZ, Cohen IS.

Circ Res. 2015 Jan 2;116(1):127-37. doi: 10.1161/CIRCRESAHA.116.303975. Review.


Role of phosphoinositide 3-kinase in the pathogenesis of acute pancreatitis.

Lupia E, Pigozzi L, Goffi A, Hirsch E, Montrucchio G.

World J Gastroenterol. 2014 Nov 7;20(41):15190-9. doi: 10.3748/wjg.v20.i41.15190. Review.


Targeting p110gamma in gastrointestinal cancers: attack on multiple fronts.

Falasca M, Maffucci T.

Front Physiol. 2014 Oct 15;5:391. doi: 10.3389/fphys.2014.00391. eCollection 2014. Review.


Targeting PI3Kγ activity decreases vascular trauma-induced intimal hyperplasia through modulation of the Th1 response.

Smirnova NF, Gayral S, Pedros C, Loirand G, Vaillant N, Malet N, Kassem S, Calise D, Goudounèche D, Wymann MP, Hirsch E, Gadeau AP, Martinez LO, Saoudi A, Laffargue M.

J Exp Med. 2014 Aug 25;211(9):1779-92. doi: 10.1084/jem.20131276. Epub 2014 Jul 29.


Cyclic nucleotide phosphodiesterases: important signaling modulators and therapeutic targets.

Ahmad F, Murata T, Shimizu K, Degerman E, Maurice D, Manganiello V.

Oral Dis. 2015 Jan;21(1):e25-50. doi: 10.1111/odi.12275. Epub 2014 Sep 12.


Astrocytes require insulin-like growth factor I to protect neurons against oxidative injury.

Genis L, Dávila D, Fernandez S, Pozo-Rodrigálvarez A, Martínez-Murillo R, Torres-Aleman I.

Version 2. F1000Res. 2014 Jan 28 [revised 2014 Apr 22];3:28. doi: 10.12688/f1000research.3-28.v2. eCollection 2014.


Simultaneous adrenal and cardiac g-protein-coupled receptor-gβγ inhibition halts heart failure progression.

Kamal FA, Mickelsen DM, Wegman KM, Travers JG, Moalem J, Hammes SR, Smrcka AV, Blaxall BC.

J Am Coll Cardiol. 2014 Jun 17;63(23):2549-57. doi: 10.1016/j.jacc.2014.02.587. Epub 2014 Apr 2.


PI3Kγ integrates cAMP and Akt signalling of the μ-opioid receptor.

Madishetti S, Schneble N, König C, Hirsch E, Schulz S, Müller JP, Wetzker R.

Br J Pharmacol. 2014 Jul;171(13):3328-37. doi: 10.1111/bph.12698.


Neuron-specific regulation of class I PI3K catalytic subunits and their dysfunction in brain disorders.

Gross C, Bassell GJ.

Front Mol Neurosci. 2014 Feb 13;7:12. doi: 10.3389/fnmol.2014.00012. eCollection 2014. Review.

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