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Results: 1 to 20 of 98

Cited In for PubMed (Select 15242608)

1.

Mechanism of Action of 2-Aminobenzamide HDAC Inhibitors in Reversing Gene Silencing in Friedreich's Ataxia.

Soragni E, Chou CJ, Rusche JR, Gottesfeld JM.

Front Neurol. 2015 Mar 5;6:44. doi: 10.3389/fneur.2015.00044. eCollection 2015.

2.

Variable Active Site Loop Conformations Accommodate the Binding of Macrocyclic Largazole Analogues to HDAC8.

Decroos C, Clausen DJ, Haines BE, Wiest O, Williams RM, Christianson DW.

Biochemistry. 2015 Mar 31;54(12):2126-35. doi: 10.1021/acs.biochem.5b00010. Epub 2015 Mar 20.

PMID:
25793284
3.

Histone deacetylase inhibitors in clinical studies as templates for new anticancer agents.

Mottamal M, Zheng S, Huang TL, Wang G.

Molecules. 2015 Mar 2;20(3):3898-941. doi: 10.3390/molecules20033898. Review.

4.

Mechanism of N-Acylthiourea-mediated activation of human histone deacetylase 8 (HDAC8) at molecular and cellular levels.

Singh RK, Cho K, Padi SK, Yu J, Haldar M, Mandal T, Yan C, Cook G, Guo B, Mallik S, Srivastava DK.

J Biol Chem. 2015 Mar 6;290(10):6607-19. doi: 10.1074/jbc.M114.600627. Epub 2015 Jan 20.

PMID:
25605725
5.

Biological targets and mechanisms of action of natural products from marine cyanobacteria.

Salvador-Reyes LA, Luesch H.

Nat Prod Rep. 2015 Feb 26;32(3):478-503. doi: 10.1039/c4np00104d.

PMID:
25571978
6.

Kinetics and thermodynamics of metal-binding to histone deacetylase 8.

Kim B, Pithadia AS, Fierke CA.

Protein Sci. 2015 Mar;24(3):354-65. doi: 10.1002/pro.2623. Epub 2015 Jan 13.

PMID:
25516458
7.

Thermodynamics of binding of structurally similar ligands to histone deacetylase 8 sheds light on challenges in the rational design of potent and isozyme-selective inhibitors of the enzyme.

Singh RK, Suzuki T, Mandal T, Balsubramanian N, Haldar M, Mueller DJ, Strode JA, Cook G, Mallik S, Srivastava DK.

Biochemistry. 2014 Dec 9;53(48):7445-58. doi: 10.1021/bi500711x. Epub 2014 Nov 26.

PMID:
25407689
8.

HDAC8 and STAT3 repress BMF gene activity in colon cancer cells.

Kang Y, Nian H, Rajendran P, Kim E, Dashwood WM, Pinto JT, Boardman LA, Thibodeau SN, Limburg PJ, Löhr CV, Bisson WH, Williams DE, Ho E, Dashwood RH.

Cell Death Dis. 2014 Oct 16;5:e1476. doi: 10.1038/cddis.2014.422.

9.

Compromised structure and function of HDAC8 mutants identified in Cornelia de Lange Syndrome spectrum disorders.

Decroos C, Bowman CM, Moser JA, Christianson KE, Deardorff MA, Christianson DW.

ACS Chem Biol. 2014 Sep 19;9(9):2157-64. doi: 10.1021/cb5003762. Epub 2014 Jul 30.

PMID:
25075551
10.

Inhibition and mechanism of HDAC8 revisited.

Chen K, Zhang X, Wu YD, Wiest O.

J Am Chem Soc. 2014 Aug 20;136(33):11636-43. doi: 10.1021/ja501548p. Epub 2014 Aug 7.

PMID:
25060069
11.

Tropolones as lead-like natural products: the development of potent and selective histone deacetylase inhibitors.

Ononye SN, VanHeyst MD, Oblak EZ, Zhou W, Ammar M, Anderson AC, Wright DL.

ACS Med Chem Lett. 2013 Jun 10;4(8):757-61. doi: 10.1021/ml400158k. eCollection 2013 Aug 8.

12.

Mutagenesis studies of the 14 Å internal cavity of histone deacetylase 1: insights toward the acetate-escape hypothesis and selective inhibitor design.

Wambua MK, Nalawansha DA, Negmeldin AT, Pflum MK.

J Med Chem. 2014 Feb 13;57(3):642-50. doi: 10.1021/jm401837e. Epub 2014 Jan 27.

13.

Loss-of-function HDAC8 mutations cause a phenotypic spectrum of Cornelia de Lange syndrome-like features, ocular hypertelorism, large fontanelle and X-linked inheritance.

Kaiser FJ, Ansari M, Braunholz D, Concepción Gil-Rodríguez M, Decroos C, Wilde JJ, Fincher CT, Kaur M, Bando M, Amor DJ, Atwal PS, Bahlo M, Bowman CM, Bradley JJ, Brunner HG, Clark D, Del Campo M, Di Donato N, Diakumis P, Dubbs H, Dyment DA, Eckhold J, Ernst S, Ferreira JC, Francey LJ, Gehlken U, Guillén-Navarro E, Gyftodimou Y, Hall BD, Hennekam R, Hudgins L, Hullings M, Hunter JM, Yntema H, Innes AM, Kline AD, Krumina Z, Lee H, Leppig K, Lynch SA, Mallozzi MB, Mannini L, McKee S, Mehta SG, Micule I; Care4Rare Canada Consortium, Mohammed S, Moran E, Mortier GR, Moser JA, Noon SE, Nozaki N, Nunes L, Pappas JG, Penney LS, Pérez-Aytés A, Petersen MB, Puisac B, Revencu N, Roeder E, Saitta S, Scheuerle AE, Schindeler KL, Siu VM, Stark Z, Strom SP, Thiese H, Vater I, Willems P, Williamson K, Wilson LC; University of Washington Center for Mendelian Genomics, Hakonarson H, Quintero-Rivera F, Wierzba J, Musio A, Gillessen-Kaesbach G, Ramos FJ, Jackson LG, Shirahige K, Pié J, Christianson DW, Krantz ID, Fitzpatrick DR, Deardorff MA.

Hum Mol Genet. 2014 Jun 1;23(11):2888-900. doi: 10.1093/hmg/ddu002. Epub 2014 Jan 8.

PMID:
24403048
14.

New and emerging HDAC inhibitors for cancer treatment.

West AC, Johnstone RW.

J Clin Invest. 2014 Jan;124(1):30-9. doi: 10.1172/JCI69738. Epub 2014 Jan 2. Review.

15.

Identification of an intrinsic determinant critical for maspin subcellular localization and function.

Dzinic SH, Kaplun A, Li X, Bernardo M, Meng Y, Dean I, Krass D, Stemmer P, Shin N, Lonardo F, Sheng S.

PLoS One. 2013 Nov 21;8(11):e74502. doi: 10.1371/journal.pone.0074502. eCollection 2013.

16.

Loop interactions and dynamics tune the enzymatic activity of the human histone deacetylase 8.

Kunze MB, Wright DW, Werbeck ND, Kirkpatrick J, Coveney PV, Hansen DF.

J Am Chem Soc. 2013 Nov 27;135(47):17862-8. doi: 10.1021/ja408184x. Epub 2013 Nov 15.

17.

Toward isozyme-selective inhibitors of histone deacetylase as therapeutic agents for the treatment of cancer.

Ononye SN, van Heyst M, Falcone EM, Anderson AC, Wright DL.

Pharm Pat Anal. 2012 May;1(2):207-21. Review.

18.

Ketone bodies as signaling metabolites.

Newman JC, Verdin E.

Trends Endocrinol Metab. 2014 Jan;25(1):42-52. doi: 10.1016/j.tem.2013.09.002. Epub 2013 Oct 18. Review.

19.

The antiparasitic clioquinol induces apoptosis in leukemia and myeloma cells by inhibiting histone deacetylase activity.

Cao B, Li J, Zhu J, Shen M, Han K, Zhang Z, Yu Y, Wang Y, Wu D, Chen S, Sun A, Tang X, Zhao Y, Qiao C, Hou T, Mao X.

J Biol Chem. 2013 Nov 22;288(47):34181-9. doi: 10.1074/jbc.M113.472563. Epub 2013 Oct 10.

20.

Small molecule inhibitors of zinc-dependent histone deacetylases.

Wagner FF, Weїwer M, Lewis MC, Holson EB.

Neurotherapeutics. 2013 Oct;10(4):589-604. doi: 10.1007/s13311-013-0226-1. Review.

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