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Items: 19


Death of a dogma: eukaryotic mRNAs can code for more than one protein.

Mouilleron H, Delcourt V, Roucou X.

Nucleic Acids Res. 2016 Jan 8;44(1):14-23. doi: 10.1093/nar/gkv1218. Epub 2015 Nov 17. Review.


The G protein α subunit variant XLαs promotes inositol 1,4,5-trisphosphate signaling and mediates the renal actions of parathyroid hormone in vivo.

He Q, Zhu Y, Corbin BA, Plagge A, Bastepe M.

Sci Signal. 2015 Aug 25;8(391):ra84. doi: 10.1126/scisignal.aaa9953.


Transcription driven somatic DNA methylation within the imprinted Gnas cluster.

Mehta S, Williamson CM, Ball S, Tibbit C, Beechey C, Fray M, Peters J.

PLoS One. 2015 Feb 6;10(2):e0117378. doi: 10.1371/journal.pone.0117378. eCollection 2015.


Gene Dosage Effects at the Imprinted Gnas Cluster.

Ball ST, Kelly ML, Robson JE, Turner MD, Harrison J, Jones L, Napper D, Beechey CV, Hough T, Plagge A, Cattanach BM, Cox RD, Peters J.

PLoS One. 2013 Jun 18;8(6):e65639. doi: 10.1371/journal.pone.0065639. Print 2013.


Loss of XLαs (extra-large αs) imprinting results in early postnatal hypoglycemia and lethality in a mouse model of pseudohypoparathyroidism Ib.

Fernández-Rebollo E, Maeda A, Reyes M, Turan S, Fröhlich LF, Plagge A, Kelsey G, Jüppner H, Bastepe M.

Proc Natl Acad Sci U S A. 2012 Apr 24;109(17):6638-43. doi: 10.1073/pnas.1117608109. Epub 2012 Apr 10.


New mutations at the imprinted Gnas cluster show gene dosage effects of Gsα in postnatal growth and implicate XLαs in bone and fat metabolism but not in suckling.

Eaton SA, Williamson CM, Ball ST, Beechey CV, Moir L, Edwards J, Teboul L, Maconochie M, Peters J.

Mol Cell Biol. 2012 Mar;32(5):1017-29. doi: 10.1128/MCB.06174-11. Epub 2012 Jan 3.


Extra-long Gαs variant XLαs protein escapes activation-induced subcellular redistribution and is able to provide sustained signaling.

Liu Z, Turan S, Wehbi VL, Vilardaga JP, Bastepe M.

J Biol Chem. 2011 Nov 4;286(44):38558-69. doi: 10.1074/jbc.M111.240150. Epub 2011 Sep 2.


Transgenic overexpression of the extra-large Gsα variant XLαs enhances Gsα-mediated responses in the mouse renal proximal tubule in vivo.

Liu Z, Segawa H, Aydin C, Reyes M, Erben RG, Weinstein LS, Chen M, Marshansky V, Fröhlich LF, Bastepe M.

Endocrinology. 2011 Apr;152(4):1222-33. doi: 10.1210/en.2010-1034. Epub 2011 Feb 8.


Potent constitutive cyclic AMP-generating activity of XLαs implicates this imprinted GNAS product in the pathogenesis of McCune-Albright syndrome and fibrous dysplasia of bone.

Mariot V, Wu JY, Aydin C, Mantovani G, Mahon MJ, Linglart A, Bastepe M.

Bone. 2011 Feb;48(2):312-20. doi: 10.1016/j.bone.2010.09.032. Epub 2010 Sep 29.


Deletion of the noncoding GNAS antisense transcript causes pseudohypoparathyroidism type Ib and biparental defects of GNAS methylation in cis.

Chillambhi S, Turan S, Hwang DY, Chen HC, Jüppner H, Bastepe M.

J Clin Endocrinol Metab. 2010 Aug;95(8):3993-4002. doi: 10.1210/jc.2009-2205. Epub 2010 May 5.


The role of GNAS and other imprinted genes in the development of obesity.

Weinstein LS, Xie T, Qasem A, Wang J, Chen M.

Int J Obes (Lond). 2010 Jan;34(1):6-17. doi: 10.1038/ijo.2009.222. Epub 2009 Oct 20. Review.


Overlapping genes produce proteins with unusual sequence properties and offer insight into de novo protein creation.

Rancurel C, Khosravi M, Dunker AK, Romero PR, Karlin D.

J Virol. 2009 Oct;83(20):10719-36. doi: 10.1128/JVI.00595-09. Epub 2009 Jul 29.


Extralarge XL(alpha)s (XXL(alpha)s), a variant of stimulatory G protein alpha-subunit (Gs(alpha)), is a distinct, membrane-anchored GNAS product that can mimic Gs(alpha).

Aydin C, Aytan N, Mahon MJ, Tawfeek HA, Kowall NW, Dedeoglu A, Bastepe M.

Endocrinology. 2009 Aug;150(8):3567-75. doi: 10.1210/en.2009-0318. Epub 2009 May 7.


The GNAS Locus: Quintessential Complex Gene Encoding Gsalpha, XLalphas, and other Imprinted Transcripts.

Bastepe M.

Curr Genomics. 2007 Sep;8(6):398-414. doi: 10.2174/138920207783406488.


Bioinformatics prediction of overlapping frameshifted translation products in mammalian transcripts.

Ribrioux S, Brüngger A, Baumgarten B, Seuwen K, John MR.

BMC Genomics. 2008 Mar 6;9:122. doi: 10.1186/1471-2164-9-122.


Lessons learned from the initial sequencing of the pig genome: comparative analysis of an 8 Mb region of pig chromosome 17.

Hart EA, Caccamo M, Harrow JL, Humphray SJ, Gilbert JG, Trevanion S, Hubbard T, Rogers J, Rothschild MF.

Genome Biol. 2007;8(8):R168.


Studies of the regulation and function of the Gs alpha gene Gnas using gene targeting technology.

Weinstein LS, Xie T, Zhang QH, Chen M.

Pharmacol Ther. 2007 Aug;115(2):271-91. Epub 2007 Apr 21. Review.


The alternative stimulatory G protein alpha-subunit XLalphas is a critical regulator of energy and glucose metabolism and sympathetic nerve activity in adult mice.

Xie T, Plagge A, Gavrilova O, Pack S, Jou W, Lai EW, Frontera M, Kelsey G, Weinstein LS.

J Biol Chem. 2006 Jul 14;281(28):18989-99. Epub 2006 May 2.


Oscillating evolution of a mammalian locus with overlapping reading frames: an XLalphas/ALEX relay.

Nekrutenko A, Wadhawan S, Goetting-Minesky P, Makova KD.

PLoS Genet. 2005 Aug;1(2):e18. Epub 2005 Aug 12.

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