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Results: 13

1.

Hydrogen tunneling links protein dynamics to enzyme catalysis.

Klinman JP, Kohen A.

Annu Rev Biochem. 2013;82:471-96. doi: 10.1146/annurev-biochem-051710-133623. Review.

PMID:
23746260
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Identification of a long-range protein network that modulates active site dynamics in extremophilic alcohol dehydrogenases.

Nagel ZD, Cun S, Klinman JP.

J Biol Chem. 2013 May 17;288(20):14087-97. doi: 10.1074/jbc.M113.453951. Epub 2013 Mar 22.

PMID:
23525111
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Structure-guided engineering of Lactococcus lactis alcohol dehydrogenase LlAdhA for improved conversion of isobutyraldehyde to isobutanol.

Liu X, Bastian S, Snow CD, Brustad EM, Saleski TE, Xu JH, Meinhold P, Arnold FH.

J Biotechnol. 2012 Dec 15;164(2):188-95. doi: 10.1016/j.jbiotec.2012.08.008. Epub 2012 Sep 3.

PMID:
22974724
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Functional divergence of FimX in PilZ binding and type IV pilus regulation.

Qi Y, Xu L, Dong X, Yau YH, Ho CL, Koh SL, Shochat SG, Chou SH, Tang K, Liang ZX.

J Bacteriol. 2012 Nov;194(21):5922-31. doi: 10.1128/JB.00767-12. Epub 2012 Aug 31.

PMID:
22942245
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Active site hydrophobic residues impact hydrogen tunneling differently in a thermophilic alcohol dehydrogenase at optimal versus nonoptimal temperatures.

Nagel ZD, Meadows CW, Dong M, Bahnson BJ, Klinman JP.

Biochemistry. 2012 May 22;51(20):4147-56. doi: 10.1021/bi3001352. Epub 2012 May 8.

PMID:
22568562
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Impaired protein conformational landscapes as revealed in anomalous Arrhenius prefactors.

Nagel ZD, Dong M, Bahnson BJ, Klinman JP.

Proc Natl Acad Sci U S A. 2011 Jun 28;108(26):10520-5. doi: 10.1073/pnas.1104989108. Epub 2011 Jun 13.

PMID:
21670258
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Update 1 of: Tunneling and dynamics in enzymatic hydride transfer.

Nagel ZD, Klinman JP.

Chem Rev. 2010 Dec 8;110(12):PR41-67. doi: 10.1021/cr1001035. No abstract available.

PMID:
21141912
[PubMed]
Free PMC Article
8.

Ligand-induced changes in the conformational stability and flexibility of glutamate dehydrogenase and their role in catalysis and regulation.

Wacker SA, Bradley MJ, Marion J, Bell E.

Protein Sci. 2010 Oct;19(10):1820-9. doi: 10.1002/pro.459.

PMID:
20665690
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

An integrated model for enzyme catalysis emerges from studies of hydrogen tunneling.

Klinman JP.

Chem Phys Lett. 2009 Mar 26;471(4-6):179-193.

PMID:
20354595
[PubMed]
Free PMC Article
10.

The functional role of a conserved loop in EAL domain-based cyclic di-GMP-specific phosphodiesterase.

Rao F, Qi Y, Chong HS, Kotaka M, Li B, Li J, Lescar J, Tang K, Liang ZX.

J Bacteriol. 2009 Aug;191(15):4722-31. doi: 10.1128/JB.00327-09. Epub 2009 Apr 17.

PMID:
19376848
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Purification and characterization of a novel recombinant highly enantioselective short-chain NAD(H)-dependent alcohol dehydrogenase from Thermus thermophilus.

Pennacchio A, Pucci B, Secundo F, La Cara F, Rossi M, Raia CA.

Appl Environ Microbiol. 2008 Jul;74(13):3949-58. doi: 10.1128/AEM.00217-08. Epub 2008 May 2.

PMID:
18456852
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Linking protein structure and dynamics to catalysis: the role of hydrogen tunnelling.

Klinman JP.

Philos Trans R Soc Lond B Biol Sci. 2006 Aug 29;361(1472):1323-31.

PMID:
16873120
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Thermal-activated protein mobility and its correlation with catalysis in thermophilic alcohol dehydrogenase.

Liang ZX, Lee T, Resing KA, Ahn NG, Klinman JP.

Proc Natl Acad Sci U S A. 2004 Jun 29;101(26):9556-61. Epub 2004 Jun 21.

PMID:
15210941
[PubMed - indexed for MEDLINE]
Free PMC Article
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