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Items: 1 to 20 of 24

1.

Targeting LKB1 in cancer - exposing and exploiting vulnerabilities.

Momcilovic M, Shackelford DB.

Br J Cancer. 2015 Aug 11;113(4):574-84. doi: 10.1038/bjc.2015.261. Epub 2015 Jul 21. Review.

2.

Dual inhibition of CDK4/Rb and PI3K/AKT/mTOR pathways by ON123300 induces synthetic lethality in mantle cell lymphomas.

Divakar SK, Ramana Reddy MV, Cosenza SC, Baker SJ, Perumal D, Antonelli AC, Brody J, Akula B, Parekh S, Premkumar Reddy E.

Leukemia. 2016 Jan;30(1):86-93. doi: 10.1038/leu.2015.185. Epub 2015 Jul 15.

PMID:
26174628
3.

MiR-204 inhibits human NSCLC metastasis through suppression of NUAK1.

Shi L, Zhang B, Sun X, Lu S, Liu Z, Liu Y, Li H, Wang L, Wang X, Zhao C.

Br J Cancer. 2014 Dec 9;111(12):2316-27. doi: 10.1038/bjc.2014.580. Epub 2014 Nov 20.

4.

Rewiring of an epithelial differentiation factor, miR-203, to inhibit human squamous cell carcinoma metastasis.

Benaich N, Woodhouse S, Goldie SJ, Mishra A, Quist SR, Watt FM.

Cell Rep. 2014 Oct 9;9(1):104-17. doi: 10.1016/j.celrep.2014.08.062. Epub 2014 Oct 2.

5.

Preclinical pharmacological evaluation of a novel multiple kinase inhibitor, ON123300, in brain tumor models.

Zhang X, Lv H, Zhou Q, Elkholi R, Chipuk JE, Reddy MV, Reddy EP, Gallo JM.

Mol Cancer Ther. 2014 May;13(5):1105-16. doi: 10.1158/1535-7163.MCT-13-0847. Epub 2014 Feb 25.

6.

Discovery of 8-cyclopentyl-2-[4-(4-methyl-piperazin-1-yl)-phenylamino]-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonitrile (7x) as a potent inhibitor of cyclin-dependent kinase 4 (CDK4) and AMPK-related kinase 5 (ARK5).

Reddy MV, Akula B, Cosenza SC, Athuluridivakar S, Mallireddigari MR, Pallela VR, Billa VK, Subbaiah DR, Bharathi EV, Vasquez-Del Carpio R, Padgaonkar A, Baker SJ, Reddy EP.

J Med Chem. 2014 Feb 13;57(3):578-99. doi: 10.1021/jm401073p. Epub 2014 Jan 24.

7.

AMPK: a contextual oncogene or tumor suppressor?

Liang J, Mills GB.

Cancer Res. 2013 May 15;73(10):2929-35. doi: 10.1158/0008-5472.CAN-12-3876. Epub 2013 May 3. Review.

8.

Next-generation sequencing identifies TGF-β1-associated gene expression profiles in renal epithelial cells reiterated in human diabetic nephropathy.

Brennan EP, Morine MJ, Walsh DW, Roxburgh SA, Lindenmeyer MT, Brazil DP, Gaora PÓ, Roche HM, Sadlier DM, Cohen CD; GENIE Consortium, Godson C, Martin F.

Biochim Biophys Acta. 2012 Apr;1822(4):589-99. doi: 10.1016/j.bbadis.2012.01.008. Epub 2012 Jan 14.

9.

NUAK2: an emerging acral melanoma oncogene.

Namiki T, Coelho SG, Hearing VJ.

Oncotarget. 2011 Sep;2(9):695-704. Review.

10.

The LKB1 complex-AMPK pathway: the tree that hides the forest.

Sebbagh M, Olschwang S, Santoni MJ, Borg JP.

Fam Cancer. 2011 Sep;10(3):415-24. doi: 10.1007/s10689-011-9457-7. Review.

11.

Siomycin A targets brain tumor stem cells partially through a MELK-mediated pathway.

Nakano I, Joshi K, Visnyei K, Hu B, Watanabe M, Lam D, Wexler E, Saigusa K, Nakamura Y, Laks DR, Mischel PS, Viapiano M, Kornblum HI.

Neuro Oncol. 2011 Jun;13(6):622-34. doi: 10.1093/neuonc/nor023. Epub 2011 May 9.

12.

Hunk is required for HER2/neu-induced mammary tumorigenesis.

Yeh ES, Yang TW, Jung JJ, Gardner HP, Cardiff RD, Chodosh LA.

J Clin Invest. 2011 Mar;121(3):866-79. doi: 10.1172/JCI42928.

13.

Posttranslational regulation of membrane type 1-matrix metalloproteinase (MT1-MMP) in mouse PTEN null prostate cancer cells: Enhanced surface expression and differential O-glycosylation of MT1-MMP.

Kim S, Huang W, Mottillo EP, Sohail A, Ham YA, Conley-Lacomb MK, Kim CJ, Tzivion G, Kim HR, Wang S, Chen YQ, Fridman R.

Biochim Biophys Acta. 2010 Nov;1803(11):1287-97. doi: 10.1016/j.bbamcr.2010.06.011. Epub 2010 Jul 8.

14.

NUAK1 links genomic instability and senescence.

Bernard D, Augert A.

Aging (Albany NY). 2010 Jun;2(6):317-9. No abstract available.

15.

AMPK as a metabolic tumor suppressor: control of metabolism and cell growth.

Luo Z, Zang M, Guo W.

Future Oncol. 2010 Mar;6(3):457-70. doi: 10.2217/fon.09.174. Review.

16.

Caenorhabditis elegans unc-82 encodes a serine/threonine kinase important for myosin filament organization in muscle during growth.

Hoppe PE, Chau J, Flanagan KA, Reedy AR, Schriefer LA.

Genetics. 2010 Jan;184(1):79-90. doi: 10.1534/genetics.109.110189. Epub 2009 Nov 9.

17.

Screening for microsatellite instability identifies frequent 3'-untranslated region mutation of the RB1-inducible coiled-coil 1 gene in colon tumors.

Paun BC, Cheng Y, Leggett BA, Young J, Meltzer SJ, Mori Y.

PLoS One. 2009 Nov 2;4(11):e7715. doi: 10.1371/journal.pone.0007715.

18.

The Snf1-related kinase, Hunk, is essential for mammary tumor metastasis.

Wertheim GB, Yang TW, Pan TC, Ramne A, Liu Z, Gardner HP, Dugan KD, Kristel P, Kreike B, van de Vijver MJ, Cardiff RD, Reynolds C, Chodosh LA.

Proc Natl Acad Sci U S A. 2009 Sep 15;106(37):15855-60. doi: 10.1073/pnas.0906993106. Epub 2009 Aug 28.

19.

RhoC promotes metastasis via activation of the Pyk2 pathway in prostate cancer.

Iiizumi M, Bandyopadhyay S, Pai SK, Watabe M, Hirota S, Hosobe S, Tsukada T, Miura K, Saito K, Furuta E, Liu W, Xing F, Okuda H, Kobayashi A, Watabe K.

Cancer Res. 2008 Sep 15;68(18):7613-20. doi: 10.1158/0008-5472.CAN-07-6700.

20.
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