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Results: 20

1.

Analysis of the clonal growth and differentiation dynamics of primitive barcoded human cord blood cells in NSG mice.

Cheung AM, Nguyen LV, Carles A, Beer P, Miller PH, Knapp DJ, Dhillon K, Hirst M, Eaves CJ.

Blood. 2013 Oct 31;122(18):3129-37. doi: 10.1182/blood-2013-06-508432. Epub 2013 Sep 12.

PMID:
24030380
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Hematopoietic stem cell gene therapy:assessing the relevance of preclinical models.

Larochelle A, Dunbar CE.

Semin Hematol. 2013 Apr;50(2):101-30. Review. No abstract available.

PMID:
24014892
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Challenges in vector and trial design using retroviral vectors for long-term gene correction in hematopoietic stem cell gene therapy.

Corrigan-Curay J, Cohen-Haguenauer O, O'Reilly M, Ross SR, Fan H, Rosenberg N, Somia N, King N, Friedmann T, Dunbar C, Aiuti A, Naldini L, Baum C, von Kalle C, Kiem HP, Montini E, Bushman F, Sorrentino BP, Carrondo M, Malech H, Gahrton G, Shapiro R, Wolff L, Rosenthal E, Jambou R, Zaia J, Kohn DB.

Mol Ther. 2012 Jun;20(6):1084-94. doi: 10.1038/mt.2012.93. No abstract available.

PMID:
22652996
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Stem cell gene therapy: the risks of insertional mutagenesis and approaches to minimize genotoxicity.

Wu C, Dunbar CE.

Front Med. 2011 Dec;5(4):356-71. doi: 10.1007/s11684-011-0159-1. Epub 2011 Dec 27. Review.

PMID:
22198747
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Genotoxicity of retroviral hematopoietic stem cell gene therapy.

Trobridge GD.

Expert Opin Biol Ther. 2011 May;11(5):581-93. doi: 10.1517/14712598.2011.562496. Epub 2011 Mar 7. Review.

PMID:
21375467
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Autologous transplantation of lentivector/acid ceramidase-transduced hematopoietic cells in nonhuman primates.

Walia JS, Neschadim A, Lopez-Perez O, Alayoubi A, Fan X, Carpentier S, Madden M, Lee CJ, Cheung F, Jaffray DA, Levade T, McCart JA, Medin JA.

Hum Gene Ther. 2011 Jun;22(6):679-87. doi: 10.1089/hum.2010.195. Epub 2011 Mar 25.

PMID:
21280983
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Large animal models of hematopoietic stem cell gene therapy.

Trobridge GD, Kiem HP.

Gene Ther. 2010 Aug;17(8):939-48. doi: 10.1038/gt.2010.47. Epub 2010 Apr 29. Review.

PMID:
20428209
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

A transposon and transposase system for human application.

Hackett PB, Largaespada DA, Cooper LJ.

Mol Ther. 2010 Apr;18(4):674-83. doi: 10.1038/mt.2010.2. Epub 2010 Jan 26. Review.

PMID:
20104209
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Retrovirus gene therapy for X-linked chronic granulomatous disease can achieve stable long-term correction of oxidase activity in peripheral blood neutrophils.

Kang EM, Choi U, Theobald N, Linton G, Long Priel DA, Kuhns D, Malech HL.

Blood. 2010 Jan 28;115(4):783-91. doi: 10.1182/blood-2009-05-222760. Epub 2009 Dec 1.

PMID:
19965657
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Transient in vivo beta-globin production after lentiviral gene transfer to hematopoietic stem cells in the nonhuman primate.

Hayakawa J, Ueda T, Lisowski L, Hsieh MM, Washington K, Phang O, Metzger M, Krouse A, Donahue RE, Sadelain M, Tisdale JF.

Hum Gene Ther. 2009 Jun;20(6):563-72. doi: 10.1089/hum.2008.186.

PMID:
19222366
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Reducing the genotoxic potential of retroviral vectors.

Ramezani A, Hawley TS, Hawley RG.

Methods Mol Biol. 2008;434:183-203. doi: 10.1007/978-1-60327-248-3_12.

PMID:
18470646
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

High incidence of leukemia in large animals after stem cell gene therapy with a HOXB4-expressing retroviral vector.

Zhang XB, Beard BC, Trobridge GD, Wood BL, Sale GE, Sud R, Humphries RK, Kiem HP.

J Clin Invest. 2008 Apr;118(4):1502-10. doi: 10.1172/JCI34371.

PMID:
18357342
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Predicting preferential DNA vector insertion sites: implications for functional genomics and gene therapy.

Hackett CS, Geurts AM, Hackett PB.

Genome Biol. 2007;8 Suppl 1:S12. Review.

PMID:
18047689
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Vector design for expression of O6-methylguanine-DNA methyltransferase in hematopoietic cells.

Schambach A, Baum C.

DNA Repair (Amst). 2007 Aug 1;6(8):1187-96. Epub 2007 May 7. Review.

PMID:
17482894
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Unique risk factors for insertional mutagenesis in a mouse model of XSCID gene therapy.

Shou Y, Ma Z, Lu T, Sorrentino BP.

Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11730-5. Epub 2006 Jul 24.

PMID:
16864781
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Busulfan pharmacokinetics, toxicity, and low-dose conditioning for autologous transplantation of genetically modified hematopoietic stem cells in the rhesus macaque model.

Kang EM, Hsieh MM, Metzger M, Krouse A, Donahue RE, Sadelain M, Tisdale JF.

Exp Hematol. 2006 Feb;34(2):132-9.

PMID:
16459181
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Acute myeloid leukemia is associated with retroviral gene transfer to hematopoietic progenitor cells in a rhesus macaque.

Seggewiss R, Pittaluga S, Adler RL, Guenaga FJ, Ferguson C, Pilz IH, Ryu B, Sorrentino BP, Young WS 3rd, Donahue RE, von Kalle C, Nienhuis AW, Dunbar CE.

Blood. 2006 May 15;107(10):3865-7. Epub 2006 Jan 26.

PMID:
16439674
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Retroviral vector integration deregulates gene expression but has no consequence on the biology and function of transplanted T cells.

Recchia A, Bonini C, Magnani Z, Urbinati F, Sartori D, Muraro S, Tagliafico E, Bondanza A, Stanghellini MT, Bernardi M, Pescarollo A, Ciceri F, Bordignon C, Mavilio F.

Proc Natl Acad Sci U S A. 2006 Jan 31;103(5):1457-62. Epub 2006 Jan 23.

PMID:
16432223
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Survival of the fittest: in vivo selection and stem cell gene therapy.

Neff T, Beard BC, Kiem HP.

Blood. 2006 Mar 1;107(5):1751-60. Epub 2005 Nov 3. Review.

PMID:
16269617
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Distinct genomic integration of MLV and SIV vectors in primate hematopoietic stem and progenitor cells.

Hematti P, Hong BK, Ferguson C, Adler R, Hanawa H, Sellers S, Holt IE, Eckfeldt CE, Sharma Y, Schmidt M, von Kalle C, Persons DA, Billings EM, Verfaillie CM, Nienhuis AW, Wolfsberg TG, Dunbar CE, Calmels B.

PLoS Biol. 2004 Dec;2(12):e423. Epub 2004 Nov 23.

PMID:
15550989
[PubMed - indexed for MEDLINE]
Free PMC Article

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