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Items: 1 to 20 of 47


Greatwall promotes cell transformation by hyperactivating AKT in human malignancies.

Vera J, Lartigue L, Vigneron S, Gadea G, Gire V, Del Rio M, Soubeyran I, Chibon F, Lorca T, Castro A.

Elife. 2015 Nov 27;4. pii: e10115. doi: 10.7554/eLife.10115.


The Yeast GSK-3 Homologue Mck1 Is a Key Controller of Quiescence Entry and Chronological Lifespan.

Quan Z, Cao L, Tang Y, Yan Y, Oliver SG, Zhang N.

PLoS Genet. 2015 Jun 23;11(6):e1005282. doi: 10.1371/journal.pgen.1005282. eCollection 2015 Jun.


LB100, a small molecule inhibitor of PP2A with potent chemo- and radio-sensitizing potential.

Hong CS, Ho W, Zhang C, Yang C, Elder JB, Zhuang Z.

Cancer Biol Ther. 2015;16(6):821-33. doi: 10.1080/15384047.2015.1040961. Epub 2015 Apr 21. Review.


MASTL promotes cyclin B1 destruction by enforcing Cdc20-independent binding of cyclin B1 to the APC/C.

Voets E, Wolthuis R.

Biol Open. 2015 Mar 6;4(4):484-95. doi: 10.1242/bio.201410793.


Entry into mitosis: a solution to the decades-long enigma of MPF.

Kishimoto T.

Chromosoma. 2015 Dec;124(4):417-28. doi: 10.1007/s00412-015-0508-y. Epub 2015 Feb 25.


Regulating Greatwall for mitosis.

Liu J.

Cell Cycle. 2015;14(6):797. doi: 10.1080/15384101.2015.1006559. No abstract available.


Regulation of Greatwall kinase by protein stabilization and nuclear localization.

Yamamoto TM, Wang L, Fisher LA, Eckerdt FD, Peng A.

Cell Cycle. 2014;13(22):3565-75. doi: 10.4161/15384101.2014.962942.


Mastl kinase, a promising therapeutic target, promotes cancer recurrence.

Wang L, Luong VQ, Giannini PJ, Peng A.

Oncotarget. 2014 Nov 30;5(22):11479-89.


Mastl is required for timely activation of APC/C in meiosis I and Cdk1 reactivation in meiosis II.

Adhikari D, Diril MK, Busayavalasa K, Risal S, Nakagawa S, Lindkvist R, Shen Y, Coppola V, Tessarollo L, Kudo NR, Kaldis P, Liu K.

J Cell Biol. 2014 Sep 29;206(7):843-53. doi: 10.1083/jcb.201406033. Epub 2014 Sep 22.


The Rim15-endosulfine-PP2ACdc55 signalling module regulates entry into gametogenesis and quiescence via distinct mechanisms in budding yeast.

Sarkar S, Dalgaard JZ, Millar JB, Arumugam P.

PLoS Genet. 2014 Jun 26;10(6):e1004456. doi: 10.1371/journal.pgen.1004456. eCollection 2014 Jun.


Greatwall-phosphorylated Endosulfine is both an inhibitor and a substrate of PP2A-B55 heterotrimers.

Williams BC, Filter JJ, Blake-Hodek KA, Wadzinski BE, Fuda NJ, Shalloway D, Goldberg ML.

Elife. 2014 Mar 11;3:e01695. doi: 10.7554/eLife.01695.


Cyclin B-Cdk1 inhibits protein phosphatase PP2A-B55 via a Greatwall kinase-independent mechanism.

Okumura E, Morita A, Wakai M, Mochida S, Hara M, Kishimoto T.

J Cell Biol. 2014 Mar 17;204(6):881-9. doi: 10.1083/jcb.201307160. Epub 2014 Mar 10.


PP2A/B55 and Fcp1 regulate Greatwall and Ensa dephosphorylation during mitotic exit.

Hégarat N, Vesely C, Vinod PK, Ocasio C, Peter N, Gannon J, Oliver AW, Novák B, Hochegger H.

PLoS Genet. 2014 Jan;10(1):e1004004. doi: 10.1371/journal.pgen.1004004. Epub 2014 Jan 2. Erratum in: PLoS Genet. 2014 Feb;10(2):e1004259.


The BEG (PP2A-B55/ENSA/Greatwall) pathway ensures cytokinesis follows chromosome separation.

Cundell MJ, Bastos RN, Zhang T, Holder J, Gruneberg U, Novak B, Barr FA.

Mol Cell. 2013 Nov 7;52(3):393-405. doi: 10.1016/j.molcel.2013.09.005. Epub 2013 Oct 10.


Greatwall is essential to prevent mitotic collapse after nuclear envelope breakdown in mammals.

Álvarez-Fernández M, Sánchez-Martínez R, Sanz-Castillo B, Gan PP, Sanz-Flores M, Trakala M, Ruiz-Torres M, Lorca T, Castro A, Malumbres M.

Proc Natl Acad Sci U S A. 2013 Oct 22;110(43):17374-9. doi: 10.1073/pnas.1310745110. Epub 2013 Oct 7.


Budding yeast greatwall and endosulfines control activity and spatial regulation of PP2A(Cdc55) for timely mitotic progression.

Juanes MA, Khoueiry R, Kupka T, Castro A, Mudrak I, Ogris E, Lorca T, Piatti S.

PLoS Genet. 2013;9(7):e1003575. doi: 10.1371/journal.pgen.1003575. Epub 2013 Jul 4.


Cell cycle regulation of Greatwall kinase nuclear localization facilitates mitotic progression.

Wang P, Galan JA, Normandin K, Bonneil É, Hickson GR, Roux PP, Thibault P, Archambault V.

J Cell Biol. 2013 Jul 22;202(2):277-93. doi: 10.1083/jcb.201211141. Epub 2013 Jul 15.


PP2A function toward mitotic kinases and substrates during the cell cycle.

Jeong AL, Yang Y.

BMB Rep. 2013 Jun;46(6):289-94. Review.


Deciphering the New Role of the Greatwall/PP2A Pathway in Cell Cycle Control.

Lorca T, Castro A.

Genes Cancer. 2012 Nov;3(11-12):712-20. doi: 10.1177/1947601912473478.


Cell cycle checkpoint regulators reach a zillion.

Yasutis KM, Kozminski KG.

Cell Cycle. 2013 May 15;12(10):1501-9. doi: 10.4161/cc.24637. Epub 2013 Apr 17. Review.

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